Analysis of the early steps of enterovirus 71 infection
| Project/Area Number |
23590557
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | The University of Tokyo (2012-2013)
Tokyo Metropolitan Organization for Medical Research (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | エンテロウイルス71 / レセプター / SCARB2 / PSGL-1 / 機能比較 / EV71 / 感染受容体 / PSGL1 |
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| Research Abstract |
Human scavenger receptor class B member 2 (SCARB2) and P-selectin glycoprotein ligand-1 (PSGL-1) have been reported te be receptors for enterovirus 71. I functionally compared these receptors. Enterovirus 71 infects more efficiently via SCARB2 than PSGL-1. The binding affinity of PSGL-1 to viral particles is stronger than that of SCARB2. The conformational alteration of enterovirus 71 is triggered by incubation with SCARB2 under acidic conditions but not by incubation with PSGL-1 under any condition which we tested.
These data suggest that SCARB2 is an authentic receptor for enterovirus 71 and PSGL-1 may act as an attachment molecule for enterovirus 71 on the cell surface.
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Report
(4 results)
Research Products
(22 results)
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[Presentation] Human SCARB2-dependent infection of clinical isolates of Coxsackievirus A14, A16 and Enterovirus 712011
Author(s)
S. Yamayoshi, S Iizuka, T. Yamashita, H. Minagawa, K. Sanjoh, N. Katsushima, T. Itagaki, K. Mizuta, Y. Nagai, M. Okamoto, H. Nishimura, K. Fujii, S. Koike
Organizer
15th International Congress of Virology
Place of Presentation
北海道
Year and Date
2011-09-15
Related Report
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[Presentation] Human SCARB2-dependent infection of clinical isolates of Coxsackievirus A14, A16 and Enterovirus 712011
Author(s)
Yamayoshi, S., S. Iizuka, T. Yamashita, H. Minagawa, K. Sanjoh, N. Katsushima, T. Itagaki, K. Mizuta, Y. Nagai, M. Okamoto, H. Nishimura, K. Fujii, S. Koike
Organizer
International Congress of Virology
Place of Presentation
北海道札幌市
Related Report
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