Elucidation of the roles of regulatory T cells in symbiosis with commensal bacteria
Project/Area Number |
23590563
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Immunology
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Research Institution | The University of Tokyo |
Principal Investigator |
NISHIO Junko 東京大学, 生産技術研究所, 特任助教 (40598679)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 腸管粘膜 / 制御性T細胞 / 免疫寛容 / Helios / 腸管粘膜恒常性 / TCRレパトワ / 腸内細菌 |
Research Abstract |
Immune system, which has been evolved to exclude pathogens, also has various mechanisms of avoidance of reaction to self tissue, which is called self-tolerance. Although intestinal immune cells continuously stimulated by intestinal commensal microbiota (CM), strong immune response to eradicate CM never occurs, suggesting intestinal mucosa bear very specific mechanisms of immune tolerance to CM. Regulatory T cells (Tregs), which play a critical role in maintenance of self-tolerance by regulating immune cell activation, are known to be accumulated in the intestinal mucosa. However, it has been remained unclear how these cells are significant and are differentiated in steady state intestinal mucosa. By using a mouse model mouse bearing limited repertoire of TCR, we demonstrated that CB-derived antigens are important for differentiation of Tregs in the intestin and these Tregs contribute to intestinal homeostasis via suppressing DC activation which results in effector T cell activation.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection2013
Author(s)
Yanai H, Matsuda A, An J, Koshiba R, Nishio J, Negishi H, Ikushima H, Onoe T, Ohdan H, Yoshida N, Taniguchi T
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Journal Title
Proc. Natl. Acad. Sci. U S A
Volume: 110(51)
Pages: 20699-704
Related Report
Peer Reviewed
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[Journal Article] Beneficial innate signaling interference for anti-bacterial responses by a TLR-mediated enhancement of the MKP-IRF3 axis2013
Author(s)
Negishi H, Matsuki K, Endo N, Sarashina H. Miki S, Matsuda A, Fukazawa K, Taguchi-Atarashi N, Ikushima H, Yanai H, Nishio J, Honda K, Fujioka Y, Ohba Y, Noda T, Taniguchi S, Nishida E, Zhang Y, Chi H, Flavell RA, Taniguchi T
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Journal Title
Proc Nat1 Acad Sci U S A
Volume: 49
Issue: 49
Pages: 19884-19889
DOI
Related Report
Peer Reviewed
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[Journal Article] Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses2012
Author(s)
Negishi H, Yanai H, Nakajima A, Koshiba R, Atarashi K, Matsuda A, Matsuki K, Miki S, Doi T, Aderem A, Nishio J, Smale ST, Honda K, Taniguchi T
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Journal Title
Nat Immunol
Volume: 13(7)
Pages: 659-666
Related Report
Peer Reviewed
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[Journal Article] Essential contribution of IRF3 to intestinal homeostasis and microbiota-mediated Tslp gene induction2012
Author(s)
Hideo Negishi, Shoji Miki, Hana Sarashina, Naoko Taguchi-Atarashi, Akira Nakajima, Kosuke Matsuki, Nobuyasu Endo, Hideyuki Yanai, Junko Nishio, Kenya Honda, and Tadatsugu Taniguchi
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Journal Title
PNAS
Volume: 109(51)
Issue: 51
Pages: 21016-21021
DOI
Related Report
Peer Reviewed
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[Presentation] Impact of TCR repertoire on intestinal homeostasis2013
Author(s)
Junko Nishio, Minato Baba, Koji Atarashi, Takeshi Tanoue, Minato Baba, Hideo Negishi, Hideyuki Yanai, Kenya Honda, Christophe Benoist, Diane Mathis, Tadatsugu Taniguchi
Organizer
日本免疫学会
Place of Presentation
千葉、幕張メッセ
Related Report
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[Presentation] Imapact of TCR repertoire on Intestinal Homeostasis2013
Author(s)
Junko Nishio, Koji Atarashi, Takeshi Tanoue, Minato Baba, Hideo Negishi, Hideyuki Yanai, Kenya Honda, Christophe Benoist, Diane Mathis, Tadatsugu Taniguchi
Organizer
Keystone Symposium; The Gut Microbiome:The Effetor/Regulatory Immune Network
Place of Presentation
Taos, New Mexico, USA
Related Report
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