| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
To elucidate the mechanism of immune tolerance in the periphery, we analyzed the role of calcium signaling in regulatory T cells and dendritic cells using cell-type specific Stim-deficient mice. In the absence of store-operated calcium entry in T cells, regulatory T cell development in the thymus was blocked at the transition of precursor cells to mature regulatory T cells. As a result, peripheral immune tolerance was disrupted. Block of calcium signaling in dendritic cells resulted in mild impairment of immune response to antigen but not of peripheral immune tolerance.
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