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Elucidation of the role of calcium signaling on peripheral immune tolerance.

Research Project

Project/Area Number 23590565
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Immunology
Research InstitutionKyushu University (2013)
Tokyo Medical and Dental University (2011-2012)

Principal Investigator

OH-HORA Masatsugu  九州大学, 生体防御医学研究所, 准教授 (40351506)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords制御性T細胞 / カルシウムシグナル / 樹状細胞 / 免疫寛容 / カルシウム / サイトカイン
Research Abstract

To elucidate the mechanism of immune tolerance in the periphery, we analyzed the role of calcium signaling in regulatory T cells and dendritic cells using cell-type specific Stim-deficient mice. In the absence of store-operated calcium entry in T cells, regulatory T cell development in the thymus was blocked at the transition of precursor cells to mature regulatory T cells. As a result, peripheral immune tolerance was disrupted. Block of calcium signaling in dendritic cells resulted in mild impairment of immune response to antigen but not of peripheral immune tolerance.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (41 results)

All 2014 2013 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results) Presentation (27 results) (of which Invited: 3 results) Book (4 results) Remarks (2 results)

  • [Journal Article] Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.2014

    • Author(s)
      Komatsu, N., Okamoto, K., Sawa, S., Nakashima, T., Oh-hora, M., Kodama, T., Tanaka, S., Bluestone, JA. and Takayanagi, H.
    • Journal Title

      Nature Medicine

      Volume: 20 Issue: 1 Pages: 62-68

    • DOI

      10.1038/nm.3432

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry2013

    • Author(s)
      Oh-hora, M., et al.
    • Journal Title

      Immunity

      Volume: 38 Issue: 5 Pages: 1-15

    • DOI

      10.1016/j.immuni.2013.02.008

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] STIM1 juxtaposes ER to phagosomes, generating Ca(2+) hotspots that boost phagocytosis2012

    • Author(s)
      Nunes, P., et al.
    • Journal Title

      Curr Biol

      Volume: 22 Issue: 21 Pages: 1990-1997

    • DOI

      10.1016/j.cub.2012.08.049

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjogren's syndrome2012

    • Author(s)
      Cheng, KT., et al
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 109 Issue: 36 Pages: 14544-14549

    • DOI

      10.1073/pnas.1207354109

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice2012

    • Author(s)
      Li, T., et al.
    • Journal Title

      Mol Cell Biol

      Volume: 32 Issue: 15 Pages: 3009-3017

    • DOI

      10.1128/mcb.06599-11

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article]2011

    • Author(s)
      Nakashima, T., et al
    • Journal Title

      Nat Med

      Volume: 17 Issue: 10 Pages: 1231-1234

    • DOI

      10.1038/nm.2452

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stanninocalcin 2 is a negative modulator of store-operated calcium entry2011

    • Author(s)
      Zeiger, W., Ito, D., Swetlik, C., Oh-hora, M., Villereal, ML. and Thinakaran, G.
    • Journal Title

      Mol Cell Biol

      Volume: 31 Issue: 18 Pages: 3710-3722

    • DOI

      10.1128/mcb.05140-11

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stanniocalcin 2 is a negative modulator of store-operated calcium entry2011

    • Author(s)
      Zeiger, W., et al.
    • Journal Title

      Mol Cell Biol

      Volume: 31 Pages: 3710-3722

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ストア作動性カルシウム流入の異常による疾患発症メカニズム2014

    • Author(s)
      大洞将嗣、小松紀子、Anjana Rao、高柳広
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] ストア作動性カルシウム流入による免疫制御2014

    • Author(s)
      大洞将嗣
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] NFAT2-dependent IL-4-producing follicular helper T cells is a critical factor in T_H2 inflammation by the lack of store-operated calcium entry2014

    • Author(s)
      Oh-hora, M., Lu, X. and Yamasaki, S.
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] NFAT2-dependent IL-4-producing follicular helper T cells is a critical factor in Th2 inflammation by the lack of store-operated calcium entry.2014

    • Author(s)
      Masatsugu Oh-hora, Xiuyuan Lu, Sho Yamasaki
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2013 Annual Research Report
  • [Presentation] ストア作動性カルシウム流入の異常による疾患発症のメカニズム2014

    • Author(s)
      9. 大洞将嗣, 小松紀子, Anjana Rao, 高柳広
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] T細胞分化とストア作動性カルシウム流入2013

    • Author(s)
      大洞将嗣、小松紀子、Anjana Rao、高柳広
    • Organizer
      第22回東京免疫フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2013-03-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Search for downstream targets of protein kinase D that is critical for T cell development2013

    • Author(s)
      Ishikawa, E., Oh-hora, M., Kurosaki, T., Saito, T. and Yamasaki, S.
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2013 Final Research Report
  • [Presentation] STIM1-mediated store operated Ca^<2+> entry is essential for basophil recruitment in IgE-mediated chronic allergic inflammation2013

    • Author(s)
      Yoshikawa, S., Oh-hora, M., Miyake, K., Li, L., Ohta, T., Adachi, T., Horiguchi, K., Kawano, Y. and Karasuyama, H.
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2013 Final Research Report
  • [Presentation] Store-operated calcium entry and T cell development2013

    • Author(s)
      Oh-hora, M., Komatsu, N., Rao, A. and Takayanagi, H.
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      千葉
    • Related Report
      2013 Final Research Report
  • [Presentation] STIM1を介したストア作動性カルシウム流入は好塩基球の脱顆粒および炎症局所への浸潤に重要である2013

    • Author(s)
      三宅健介、吉川宗一郎、大洞将嗣、烏山一
    • Organizer
      第63回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Store-operated calcium entry is crucial for the development of agonist-selected T cells2013

    • Author(s)
      Oh-hora, M., Komatsu, N., Rao, A. and Takayanagi, H.
    • Organizer
      FASEB Science Research Conference
    • Place of Presentation
      Nassau, Bahamas
    • Related Report
      2013 Final Research Report
  • [Presentation] Strong TCR/calcium signaling specifically controls the development of regulatory T cell subsets2013

    • Author(s)
      大洞将嗣、小松紀子、Stefan Feske、堀昌平、Anjana Rao、高柳広
    • Organizer
      Frontiers in Immunology and Inflammation
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Store-operated calcium entry is crucial for the development of agonist-selected T cells.2013

    • Author(s)
      Masatsugu Oh-hora, Noriko Komatsu, Anjana Rao, Hiroshi Takayanagi
    • Organizer
      FASEB Science Research Conference
    • Place of Presentation
      Nassau, Bahamas
    • Related Report
      2013 Annual Research Report
  • [Presentation] STIM1を介したストア作動性カルシウム流入は好塩基球の脱下流および炎症局所への浸潤に重要である2013

    • Author(s)
      三宅健介, 吉川宗一郎, 大洞将嗣, 烏山一
    • Organizer
      第63回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Store-operated calcium entry and T cell development.2013

    • Author(s)
      Masatsugu Oh-hora, Noriko Komatsu, Anjana Rao, Hiroshi Takayanagi
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] STIM1-mediated store operated Ca2+ entry is essential for basophil recruitment in IgE-mediated chronic allergic inflammation.2013

    • Author(s)
      Soichiro Yoshikawa, Masatsugu Oh-hora, Kensuke Miyake, Lihua Li, Takuya Ohta, Takahiro Adachi, Kayo Horiguchi, Yohei Kawano, Hajime Karasuyama
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2013 Annual Research Report
  • [Presentation] Search for downstream targets of protein kinase D that is critical for T cell development.2013

    • Author(s)
      Eri Ishikawa, Masatsugu Oh-hora, Tomohiro Kurosaki, Takasi Saito, Sho Yamasaki
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2013 Annual Research Report
  • [Presentation] T細胞分化とストア作動性カルシウム流入2013

    • Author(s)
      大洞将嗣、小松紀子、Anjana Rao、高柳広
    • Organizer
      第22回東京免疫フォーラム
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] STIM依存性カルシウム流入によるT細胞の分化制御2012

    • Author(s)
      大洞将嗣
    • Organizer
      第122回小児血液腫瘍懇話会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-02
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 小胞体カルシウムセンサーSTIMによるT細胞分化制御2012

    • Author(s)
      大洞将嗣
    • Organizer
      第8回骨免疫ワークショップ
    • Place of Presentation
      東京
    • Year and Date
      2012-11-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Agonist-selected T cell development requires strong TCR/calcium signaling2012

    • Author(s)
      Oh-hora, M.,Komastu, N., Feske, S.,Hori, S., Rao, A. and Takayanagi, H.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] STIM1-mediated store operated Ca^2+ entry is essential for basophil recruitment in IgE-mediated chronic allergic inflammation2012

    • Author(s)
      Yoshikawa, S., Egawa, M., Oh-hora, M., Adachi, T., Horiguchi, K., Li, L., Ohta, T., Kawano, Y., Minagishi, Y. and Karasuyama, H.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] Agonist-selected T cell development requires strong TCR/calcium signaling2012

    • Author(s)
      大洞将嗣、小松紀子、Stefan Feske、堀昌平、Anjana Rao、高柳広
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] Agonist-selected T cell development requires strong TCR/calcium signaling2012

    • Author(s)
      大洞将嗣、小松紀子、高柳広
    • Organizer
      第22回KTCC
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Agonist-selected T cell development requires strong TCR/calcium signaling2011

    • Author(s)
      大洞将嗣、小松紀子、高柳広
    • Organizer
      第22回Kyoto T cell conference (KTCC)
    • Place of Presentation
      京都
    • Year and Date
      2011-06-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Lineage-specific requirement of store-operated calcium entry in T cell lineage development2011

    • Author(s)
      大洞 将嗣
    • Organizer
      第21回KTCC
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] 小胞体カルシウムセンサーSTIM によるT細胞分化制御

    • Author(s)
      大洞将嗣
    • Organizer
      第8回骨免疫ワークショップ
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] イラストで徹底理解するシグナル伝達キーワード事典2012

    • Author(s)
      大洞将嗣、高柳広
    • Publisher
      羊土社
    • Related Report
      2013 Final Research Report
  • [Book] イラストで徹底理解するシグナル伝達キーワード事典2012

    • Author(s)
      大洞将嗣、黒崎知博
    • Publisher
      羊土社
    • Related Report
      2013 Final Research Report
  • [Book] イラストで徹底理解する シグナル伝達キーワード事典2012

    • Author(s)
      大洞将嗣、高柳広
    • Publisher
      羊土社
    • Related Report
      2012 Research-status Report
  • [Book] イラストで徹底理解する シグナル伝達キーワード事典2012

    • Author(s)
      大洞将嗣、黒崎知博
    • Publisher
      羊土社
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.bioreg.kyushu-u.ac.jp/mib/divisions/summary_in_mi.pdf

    • Related Report
      2013 Final Research Report
  • [Remarks] 過剰な免疫反応にブレーキをかけるT細胞が作られる共通の仕組みを解明

    • URL

      http://www.jst.go.jp/pr/announce/20130315/

    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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