Multiple functions of ASC that mainly regulates the formation of inflammasome
| Project/Area Number |
23590566
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | Shinshu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HIDA Shigeaki 信州大学, 医学系研究科, 准教授 (10345762)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | ASC / Inflammasome / innate immunity / cell death / cancer / fascin / IL-1beta / IFNbeta / Inflamasome / inflammasome / 細胞死 / がん / 炎症 / 分子相互作用 / 細胞増殖制御 / 免疫監視機構 |
|---|
| Research Abstract |
ASC responsible for inflammasome fomrmation is involved in both pro-inflammation and pro-apoptosis. We observed the occurrence of the colon cancer was clearly retarded by ASC deletion from Ahr-/-mouse, a prone to colon cancer. In Ahr-/-mice, it was observed that an oncogene beta-catenin was accumulated in nuclei of the intestinal epithelium associated with an increase in the epression of IL-1 1 beta and severe inflammation was suppressed. On one hand, we observed that the metastatic potential of cancer cells were enhanced by ASC knock-down, while Asc over-expression suppressed the survival of cancer cells specifically in the confluent state.
When we searched for the ASC binding proteins by immunoprecipitaiton and mass spectrometer, cytoskeletal and signal transduction-relating molecules, such as Fascine and IQGAP were, and their direct interaction with ASC was confirmed. The investigation of the biological significance of the interaction is underway.
|
Report
(4 results)
Research Products
(34 results)
-
[Journal Article] Nucleic acid sensing by T cells initiates Th2 cell differentiation.2014
Author(s)
Imanishi T, Ishihara C, Badr Mel S, Hashimoto-Tane A, Kimura Y, Kawai T, Takeuchi O, Ishii KJ, Taniguchi S, Noda T, Hirano H, Brombacher F, Barber GN, Akira S, Saito T
-
Journal Title
Nat Commun
Volume: 10
Issue: 1
Pages: 3566-3566
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] NLRP3 Regulates Neutrophil Functions and Contributes to Hepatic Ischemia-Reperfusion Injury Independently of Inflammasomes.2014
Author(s)
Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki, Nishimura S, Sagara J, Noda T, IwakuraY, Hiroko Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M.
-
Journal Title
J Immunol
Volume: 192(9)
Issue: 9
Pages: 4342-4351
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] ASC in Renal Collecting Duct Epithelial Cells Contributes to Inflammation and Injury after Unilateral Ureteral Obstruction2014
Author(s)
Komada T, Usui F, Shirasuna K, Kawashima A, Kimura H, Karasawa T, Nishimura S, Sagara J, Noda T, Taniguchi S, Muto S, Nagata D, Kusano E, Takahashi M
-
Journal Title
American Journal of Pathology
Volume: 184(5)
Issue: 5
Pages: 1287-1298
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Beneficial innate signaling interference for anti-bacterial responses by a TLR-mediated enhancement of the MKP-IRF3 axis2013
Author(s)
Negishi H, Matsuki K, Endo N, Sarashina H. Miki S, Matsuda A, Fukazawa K, Taguchi-Atarashi N, Ikushima H, Yanai H, Nishio J, Honda K, Fujioka Y, Ohba Y, Noda T, Taniguchi S, Nishida E, Zhang Y, Chi H, Flavell RA, Taniguchi T
-
Journal Title
Proc Nat1 Acad Sci U S A
Volume: 49
Issue: 49
Pages: 19884-19889
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
