Regulation of diseases by chronic inflammation and obesity

• Project/Area Number: 23590567
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Immunology
• Research Institution: Mie University
• Principal Investigator: OGATA Masato 三重大学, 医学(系)研究科(研究院), 教授 (60224094)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 慢性炎症 / MAPキナーゼ / 血液細胞 / 代謝症候群 / p38 / 遺伝子改変マウス

Research Abstract

It is well established that obesity can exacerbate metabolic syndrome and glucose tolerance through induction of chronic inflammation. We have established p38alpha mutant mice in which p38alpha gene is disrupted in the hematopoietic cells. It is found that high fat diet-induced chronic inflammation in the adipose tissue and glucose tolerance is ameliorated in the mutant mice, suggesting that the p38alpha signaling cascade in the hematopoietic cells could be involved in the regulation of obesity-induced chronic inflammation and metabolic syndrome.

Research Products

• [Journal Article] Critical role of p38 MAPK for regeneration of the sciatic nerve following crush injury in vivo (2013)
  • Author(s): Kato, N., Matsumoto, M., Kogawa, M., Atkins, G.J., Findlay, D.M., Fujikawa, T., Oda, H., and Ogata, M.
  • Journal Title: Journal of neuroinflammation Volume: 10 Issue: 1 Pages: 1-1
  • DOI: 10.1186/1742-2094-10-1
  • Peer Reviewed
• [Journal Article] MAPK1 is required for establishing the pattern of cell proliferation and for cell survival during lens development (2013)
  • Author(s): Upadhya, D., Ogata, M., and Reneker, L.W.
  • Journal Title: Development Volume: 140 Issue: 7 Pages: 1573-1582
  • DOI: 10.1242/dev.081042
  • Peer Reviewed
• [Journal Article] Critical role of p38 MAPK for regeneration of the sciatic nerve following crush injury in vivo. (2013)
  • Author(s): Kato, N., et. al.
  • Journal Title: Journal of Neuroinflammation Volume: 10
  • Peer Reviewed
• [Journal Article] MAPK1 is required for establishing the pattern of cell proliferation and for cell survival during lens development (2013)
  • Author(s): Upadhya, D., et. al
  • Journal Title: Development Volume: 140
  • Peer Reviewed
• [Presentation] 血球系p38alpha MAPキナーゼによるインスリン抵抗性および肥満の制御 (2014)
  • Author(s): 大隈貞嗣、藤川隆彦、緒方正人
  • Organizer: 第6回日本プロテインホスファターゼ研究会学術集会
  • Place of Presentation: 三重大学環境・情報科学館(三重)
  • Year and Date: 2014-02-20
• [Presentation] p38alpha mitogen-activated protein kinase in blood cells regulates high-fat-induced insulin resistance and obesity (2013)
  • Author(s): Sadatsugu Ookuma, and Masato Ogata
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2013-12-13
• [Presentation] p38alpha in blood cells regulates high-fat-induced insulin resistance and obesity (2013)
  • Author(s): Sadatsugu Ookuma, Takahiko Fujikawa, Kinya Otsu, and Masato Ogata
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2013-09-13
• [Presentation] p38αin blood cells regulates insulin resistance in mice (2013)
  • Author(s): Sadatsugu Ookuma and Masato Ogata
  • Organizer: 10th International Conference on Protein Phosphatase
  • Place of Presentation: 国立がん研究センター(東京)
  • Year and Date: 2013-02-08
• [Presentation] p38α in blood cells regulates insulin resistance in mice (2013)
  • Author(s): S. Ookuma, et. al.
  • Organizer: 10th International Conference on Protein Phosphatase
  • Place of Presentation: 国立がん研究センター（東京）
• [Presentation] p38alpha regulates high-fat-induced chronic inflammation and hyperglycemia via blood cells (2012)
  • Author(s): Sadatsugu Ookuma, Takahiko Fujikawa, Kazuto Sugimura, Kinya Otsu, and Masato Ogata
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 2012-12-16
• [Presentation] Roles of p38alpha mitogen-activated protein kinase in blood cells in high-fat-induced chronic inflammation and insulin resistance (2012)
  • Author(s): Sadatsugu Ookuma, Kazuto Sugimura, and Masato Ogata
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2012-12-07
• [Presentation] p38αMAPキナーゼは血球系を介してインスリン耐性を制御する (2012)
  • Author(s): 大隈貞嗣、杉村和人、藤川隆彦、緒方正人
  • Organizer: 第5回日本プロテインホスファターゼ研究会学術集会
  • Place of Presentation: 大阪大学銀杏会館(大阪)
  • Year and Date: 2012-01-19
• [Presentation] p38alpha regulates high-fat-induced chronic inflammation and hyperglycemia via blood cells (2012)
  • Author(s): S. Ookuma, et. al.
  • Organizer: 第85回日本生化学学会大会
  • Place of Presentation: 福岡国際会議場（福岡）
• [Presentation] Roles of p38alpha mitogen-activated protein kinase in blood cells in high-fat-induced chronic inflammation and insulin resistance. (2012)
  • Author(s): S. Ookuma, et. al.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場（神戸）
• [Presentation] p38αMAPキナーゼは血球系を介してインスリン耐性を制御する (2012)
  • Author(s): 大隈貞嗣、他
  • Organizer: 第5回日本プロテインホスファターゼ研究会学術集会
  • Place of Presentation: 大阪大学銀杏会館（大阪）
• [Presentation] Systemic roles of MAP kinases in hematopoietic cells (2011)
  • Author(s): Masato Ogata
  • Organizer: The First Japan-Taiwan Bilateral Conference on Protein Phosphatases
  • Place of Presentation: National Institute for Basic Biology (Okazaki)
  • Year and Date: 2011-12-02
  • Invited
• [Presentation] p38alpha mitogen-activated protein kinase in blood cells regulates insulin resistance and expression of inflammatory genes (2011)
  • Author(s): Sadatsugu Ookuma, Kazuki Tauchi, Takahiko Fujikawa, Kazuto Sugimura, Kinya Otsu, and Masato Ogata
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-29
• [Presentation] p38alpha mitogen-activated protein kinase in blood cells is involved in insulin resistance (2011)
  • Author(s): Sadatsugu Ookuma, Kazuki Tauchi, Takahiko Fujikawa, Kazuto Sugimura, Kinya Otsu, and Masato Ogata
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2011-09-23
• [Presentation] p38alpha mitogen-activated protein kinase in blood cells is involved in insulin resistance. (2011)
  • Author(s): S. Ookuma, et. al.
  • Organizer: 第84回日本生化学学会大会
  • Place of Presentation: 国立京都国際会館（京都）
• [Presentation] p38alpha mitogen-activated protein kinase in blood cells regulates insulin resistance and expression of inflammatory genes. (2011)
  • Author(s): S. Ookuma, et. al.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ（千葉）
• [Presentation] Systemic roles of MAP kinases in hematopoietic cells. (2011)
  • Author(s): Masato Ogata
  • Organizer: The First Japan-Taiwan Bilateral Conference on Protein Phosphatases.(招待講演)
  • Place of Presentation: National Institute for Basic Biology (Okazaki)
• [Presentation] p38alpha in blood cells regulates high-fat-induced insulin resistance and obesity
  • Author(s): Sadatsugu Ookuma, Takahiko Fujikawa, Kinya Otsu, and Masato Ogata.
  • Organizer: 第85回日本生化学学会大会
  • Place of Presentation: 国立京都国際会館（京都）
• [Presentation] p38alpha mitogen-activated protein kinase in blood cells regulates high-fat-induced insulin resistance and obesity
  • Author(s): Sadatsugu Ookuma, Masato Ogata.
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ（千葉）
• [Presentation] 血球系p38alpha MAPキナーゼによるインスリン抵抗性および肥満の制御
  • Author(s): 大隈貞嗣、藤川隆彦、緒方正人
  • Organizer: 第６回日本プロテインホスファターゼ研究会学術集会
  • Place of Presentation: 三重大学環境・情報科学館（三重）