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Analysis on regulatory mechanism of B cell selection by novel signaling molecule in germinal center

Research Project

Project/Area Number 23590568
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Immunology
Research InstitutionKyoto University

Principal Investigator

HIKIDA Masaki  京都大学, 医学(系)研究科(研究院), 教授 (60228715)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords胚中心 / B細胞 / 分化 / シグナル / 選択 / 免疫応答 / CD3 / 胚中心B細胞
Research Abstract

We have found that a subset of germinal center B cells is expressing CD3e, which have been widely known as a T cell-specific signaling molecule. The germinal center B cells we have observed were proliferating cells and we have also observed that CD3e is involved in apoptosis of these B cells. These results suggest that still unknown molecules are playing essential roles in positive and/or negative selection in the germinal center B cells. Also, we have found that this cell number of this population was increased in a autoimmune-prone model mice strain compared to the wild type mice. This may suggest the involvement of this population in autoimmune diseases.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2014 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (3 results) (of which Invited: 1 results)

  • [Journal Article] IgG1 cytoplasmic tail is essential for cell surface expression in Igβ down-regulated cells.2014

    • Author(s)
      Kagefumi Todo, Orie Koga, Miwako Nishikawa, Masaki Hikida
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 445 Issue: 3 Pages: 572-577

    • DOI

      10.1016/j.bbrc.2014.02.037

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IgG1 cytoplasmic tail is essential for cell surface expression in Igβdown-regulated cells

    • Author(s)
      Todo K, Koga O, Nishikawa M, Hikida M.
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 445(3) Pages: 572-577

    • Related Report
      2013 Final Research Report
  • [Presentation] Roles of Igb in the generation of autoreactive B cells in BXSB-Yaa autoimmune prone mice2013

    • Author(s)
      Masaki Hikida and Todo Kagefumi
    • Organizer
      日本免疫学会
    • Related Report
      2013 Final Research Report
  • [Presentation] Roles of Igβ in the generation of autoreactive B cells in BXSB-Yaa autoimmune prone mice2013

    • Author(s)
      Masaki Hikida
    • Organizer
      日本免疫学会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Roles of Igβin the generation of autoreactive B cells in BXSB-Yaa autoimmune prone mouse2012

    • Author(s)
      Todo Kagefumi and Masaki Hikida
    • Organizer
      日本免疫学会
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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