IL-17-mediated regulation of a granuloma formation in pulmonary mycobacterial infection.
| Project/Area Number |
23590571
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
UMEMURA Masayuki 琉球大学, 熱帯生物圏研究センター, 准教授 (90359985)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUZAKI Goro 琉球大学, 熱帯生物圏研究センター, 教授 (30229455)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 結核 / 肉芽腫 / IL-17A / IL-17F / IL-17 / 結核菌 / 肺 / TCR γδ T細胞 |
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| Outline of Final Research Achievements |
The IL-17 cytokine family is comprised of six members, IL-17A to F. Both IL-17A and IL-17F have been considered to be linked to various diseases. However, the involvement of IL-17F in mycobacterial infection is unknown. In this study, a possible role of IL-17F in the course of pulmonary mycobacterial infection was investigated.
IL-17A producing cells are detected in a population of T cells. However, IL-17F producing cells were hardly detected in lymphocytes. We found that majority of IL-17F producing cells were the alveolar epithelial cells.
Our results suggest that IL-17F expressed by alveolar epithelial cells support mature granuloma formation at an early stage of pulmonary mycobacterial infection, its contribution decreases at a chronic infection stage possibly because the expansion of granuloma forces the IL-17F-producing epithelial cells away from the center of granulomas.
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Report
(5 results)
Research Products
(49 results)
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[Journal Article] Interleukin-17A is involved in enhancement of tumor progression in murine intestine.2011
Author(s)
Oshiro, K., Kohama, H., Umemura, M., Uyttenhove, C., Inagaki-Ohara, K., Arakawa, T., Harada, M., Nakae, S., Iwakura, Y., Nishimaki, T. and Matsuzaki, G.
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Journal Title
Immunobiology
Volume: 217
Pages: 54-60
Related Report
Peer Reviewed
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[Presentation] マイコバクテリア感染におけるIL-17F産生細胞の同定2015
Author(s)
梅村正幸, 福井雅之, 當山清悟, 山﨑雅俊, 福井知穂, 照屋尚子, 田村敏生, 中江進, 岩倉洋一郎, 松崎吾朗
Organizer
第87回日本細菌学会総会
Place of Presentation
長良川国際会議場, 岐阜県岐阜市
Year and Date
2015-03-26 – 2015-03-28
Related Report
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[Presentation] Characterization and localization of IL-17F-producing cells during mycobacterial infection.2014
Author(s)
Umemura, M., Fukui, M., Touyama, S., Fukui, F., Teruya, N., Tamura, T., Nakae, S., Iwakura, Y., Matsuzaki, G.
Organizer
第87回日本細菌学会総会
Place of Presentation
タワーホール船堀, 東京都江戸川区
Related Report
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[Presentation] Involvement of IL-17A-producing TCR γδ T cells in late protective immunity against pulmonary mycobacterial infection.2013
Author(s)
Umemura, M., Touyama, S., Fukui, M., Yahagi, A., Nakae, S. Iwakura, Y., Matsuzaki, G.
Organizer
IMMUNOLOGY 2013
Place of Presentation
Hawaii, USA
Related Report
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[Presentation] Role of interleukin-17F in pulmonary mycobacterial infection.2013
Author(s)
Umemura, M., Touyama, S., Fukui, M., Yoshida-Okamoto, Y., Yahagi, A., Fukui, C., Nakae, S., Iwakura, Y., Matsuzaki, G.
Organizer
The 78th Meeting of the Japanese Society for Interferon and Cytokine Research/The 21th International Symposium of Macrophage Molecular and Cellular Biology 2013
Place of Presentation
Tokyo
Related Report
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[Presentation] Mechanism of IL-17A-mediated enhancement of protective immunity against Listeria monocytogenes infection. 15th International Congress of Immunology2013
Author(s)
Matsuzaki, G., Okita, Y., Shiono, T., Hamada, S., Umemura, M.
Organizer
15th International Congress of Immunology
Place of Presentation
Milan, Italy
Related Report
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[Presentation] Identification of IL-17F-producing cells during mycobacterial infection.2013
Author(s)
Umemura, M., Touyama S., Fukui, M., Fukui, C., Nakae, S., Iwakura, Y., Matsuzaki, G.
Organizer
第42回日本免疫学会学術集会
Place of Presentation
幕張メッセ国際会議場, 千葉県千葉市
Related Report
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[Presentation] Induction of early immunity against pulmonary Mycobacterium tuberculosis infection in mice by combination of BCG priming vaccine and boosting micosal vaccine with a recombinant mycobacterial antigen.2013
Author(s)
Fukui, M., Umemura, M., Miyata, T., Harakuni, T., Arakawa, T., Matsuzaki, G.
Organizer
第42回日本免疫学会学術集会
Place of Presentation
幕張メッセ国際会議場, 千葉県千葉市
Related Report
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