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Molecular and cellular mechanism controlling IgE-producing B cells that contributes to the pathogenesis of allergic diseases.

Research Project

Project/Area Number 23590573
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Immunology
Research InstitutionOita University (2012-2013)
Keio University (2011)

Principal Investigator

KOBAYASHI Takashi  大分大学, 医学部, 教授 (30380520)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsアレルギー / B細胞 / シグナル伝達 / IgE / 可視化 / 制御性T細胞
Research Abstract

B cell-specific disruption of SOCS1 which is a suppressor of cytokine signaling in mice results in the elevation of serum IgE levels. Homozygous deletion of SOCS1 gene in B cells enhanced the susceptibility to development of allergen-induced airway inflammation, allergic rhinitis and otitis media, but not the development of germinal center B cells or memory B cells. On the other hand, Treg-specific TRAF6 deficient mice dramatically increased Th2 cytokine production leading to the hyper IgE syndrome, and developed allergic skin diseases, arthritis, lymphadenopathy. These results suggest that both SOCS1 and TRAF6 may contribute to the pathogenesis of allergic diseases.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (43 results)

All 2014 2013 2012 2011 Other

All Journal Article (21 results) (of which Peer Reviewed: 20 results,  Open Access: 2 results) Presentation (19 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Dengue transmission model by means of viremic adult immuno-competent mouse2014

    • Author(s)
      Lucky Ronald Runtuwene, Eiji Konishi, Atsushi Yamanaka, Yoshihiro Makino, Yutaka Suzuki, Tomohiko Takasaki, Ichiro Kurane, Takashi Kobayashi and Yuki Eshita
    • Journal Title

      Parasites & Vectors

      Volume: 7 Issue: 1 Pages: 143-143

    • DOI

      10.1186/1756-3305-7-143

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vector competence of Aedes aegypti to dengue virus.2014

    • Author(s)
      Lucky Ronald Runtuwene, Kaori Noguchi, Akinori Tokunaga, Takashi Kobayashi, Kenta Nakai and Yuki Eshita
    • Journal Title

      Urban Pest Management

      Volume: 4 (1)

    • NAID

      110009818404

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DEAE-デキストラン-MMA グラフト共重合体をホストとして用い、ゲストのパクリタキセルと成る、超分子複合体-その人工酵素、抗癌メカニズム2014

    • Author(s)
      大西 靖彦・江下 優樹・紀 瑞成・小林隆志・大西 政康・水野 正明・吉田 純・久保田 直治
    • Journal Title

      大分大学工学部研究報告

      Volume: -

    • NAID

      120005539559

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRAF6 Is Essential for Maintenance of Regulatory T Cells That Suppress Th2 Type Autoimmunity2013

    • Author(s)
      Muto G, Kotani H, Kondo T, Morita R, Tsuruta S, Kobayashi T, Luche H, Fehling HJ, Walsh M, Choi Y, Yoshimura A
    • Journal Title

      PLoS One

      Volume: 8(9)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of human autoimmune regulator (AIRE) gene translation by miR-220b2013

    • Author(s)
      Matsuo T, Noguchi Y, Shindo M, Morita Y, Oda Y, Yoshida E, Hamada H, Harada M, Shiokawa Y, Nishida T, Tominaga R, Kikushige Y, Akashi K, Kudoh J, Shimizu N, Tanaka Y, Umemura T, Taniguchi T, Yoshimura A, Kobayashi T, Mitsuyama M, Kurisaki H, Katsuta H, Nagafuchi S
    • Journal Title

      Gene

      Volume: 530(1) Pages: 19-25

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of human autoimmune regulator (AIRE) gene translation by miR-220b2013

    • Author(s)
      Matsuo T, Noguchi Y, Shindo M, Morita Y, Oda Y, Yoshida E, Hamada H, Harada M, Shiokawa Y, Nishida T, Tominaga R, Kikushige Y, Akashi K, Kudoh J, Shimizu N, Tanaka Y, Umemura T, Taniguchi T, Yoshimura A, Kobayashi, T., Mitsuyama M, Kurisaki H, Katsuta H, Nagafuchi S.
    • Journal Title

      Gene

      Volume: 530 (1) Issue: 1 Pages: 19-25

    • DOI

      10.1016/j.gene.2013.08.015

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRAF6 Is Essential for Maintenance of Regulatory T Cells That Suppress Th2 Type Autoimmunity.2013

    • Author(s)
      Muto G, Kotani H, Kondo T, Morita R, Tsuruta S, Kobayashi, T., Luche H, Fehling HJ, Walsh M, Choi Y, Yoshimura A.
    • Journal Title

      PLoS One

      Volume: 8 (9) Issue: 9 Pages: e74639-e74639

    • DOI

      10.1371/journal.pone.0074639

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple infections with helminthes -whipworm, hookworm, and roundworm2013

    • Author(s)
      Kunimitsu Inoue, Sotaro Ozaka, Kazuhisa Okamoto, Ryu Ogawa, Kazuhiro Mizukami, Tadayoshi Okimoto, Masaaki Kodama, Takashi Kobayashi, Yuki Eshita, Hideo Hasegawa, Kazunari Murakami
    • Journal Title

      Endoscopy

      Volume: 46 Issue: S 01 Pages: 117-118

    • DOI

      10.1055/s-0034-1364887

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Supramolecular targeting of B16F10 melanoma cells with nanoparticles consisting of a DEAE-dextran-MMA copolymer-paclitaxel complex in vivo and in vitro.2012

    • Author(s)
      Yuki Eshita, Rui-Cheng Ji, Masayasu Onishi, Lucky Ronald Runtuwene, Kaori Noguchi, Takashi Kobayashi, Masaaki Mizuno, Jun Yoshida, Naoji Kubota and Yasuhiko Onishi
    • Journal Title

      J. Nanomed. Biotherapeut. Discov.

      Volume: 2 Issue: 05 Pages: 109-109

    • DOI

      10.4172/2155-983x.1000109

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Positive regulation of osteoclastic differentiation by growth differentiation factor-15 up-regulated in osteocytic cells under hypoxia2012

    • Author(s)
      Hinoi E, Ochi H, Takarada T, Nakatani E, Iezaki T, Nakajima H, Fujita H, Takahata Y, Hidano S, Kobayashi T, Takeda S, Yoneda Y
    • Journal Title

      J Bone Miner Res

      Volume: 27(4) Pages: 938-949

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] TGFβ-Activated Kinase 1 (TAK1)-Binding Proteins (TAB) 2 and 3 Negatively Regulate Autophagy2011

    • Author(s)
      Takaesu G, Kobayashi T, Yoshimura A
    • Journal Title

      J Biochem

      Volume: 151(2) Pages: 157-166

    • NAID

      10031166054

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-1beta and TNFalpha-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis2011

    • Author(s)
      Mori T, Miyamoto T, Yoshida H, Asakawa M, Kawasumi M, Kobayashi T, Morioka H, Chiba K, Toyama Y, Yoshimura A
    • Journal Title

      Int Immunol

      Volume: 23(11) Pages: 701-712

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteoclasts are dispensable for haematopoietic stem cell maintenance and mobilization2011

    • Author(s)
      Miyamoto K, Yoshida S, Kawasumi M, Hashimoto K, Kimura T, Sato Y, Kobayashi T, Miyauchi Y, Hoshi H, Iwasaki R, Miyamoto H, Hao W, Morioka H, Chiba K, Kobayashi T, Yasuda H, Penninger JM, Toyama Y, Suda T and Miyamoto T
    • Journal Title

      J Exp Med

      Volume: 208(11) Pages: 2175-2181

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A germ cell specific gene, Prmt5 works as somatic cell reprogramming2011

    • Author(s)
      Nagamatsu G, Kosaka T, Kawasumi M, Kinoshita T, Takubo K, Akiyama H, Sudo T, Kobayashi T, Oya M, and Suda T
    • Journal Title

      J Biol Chem

      Volume: 286(12) Pages: 10641-10648

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant IL-4 production by SOCS3-over-expressing T cells during infection with Leishmania major exacerbates disease manifestations2011

    • Author(s)
      Nakaya M, Hamano S, Kawasumi M, Yoshida H, Yoshimura A, Kobayashi T
    • Journal Title

      Int Immunol

      Volume: 23 Pages: 195-202

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant IL-4 production by SOCS3-overexpressing T cells during infection with Leishmania major exacerbates disease manifestations2011

    • Author(s)
      Nakaya, M., Hamano, S., Yoshida, H., Yoshimura, A., Kobayashi, T.
    • Journal Title

      Int.Immunol.

      Volume: 23 Issue: 3 Pages: 195-202

    • DOI

      10.1093/intimm/dxq472

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A germ cell specific gene, Prmt5 works as somatic cell reprogramming.2011

    • Author(s)
      Nagamatsu G, Kosaka T, Kawasumi M, Kinoshita T, Takubo K, Akiyama H, Sudo T, Kobayashi T, Oya M, and Suda T
    • Journal Title

      J Biol Chem.

      Volume: 286 Issue: 12 Pages: 10641-10648

    • DOI

      10.1074/jbc.m110.216390

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Osteoclasts are dispensable for haematopoietic stem cell maintenance and mobilization2011

    • Author(s)
      Miyamoto K, et al
    • Journal Title

      J Exp Med

      Volume: 208 Issue: 11 Pages: 2175-2181

    • DOI

      10.1084/jem.20101890

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] IL-1β and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis2011

    • Author(s)
      Mori T, et al
    • Journal Title

      Int Immunol

      Volume: 23 Issue: 11 Pages: 701-712

    • DOI

      10.1093/intimm/dxr077

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] TGF-beta-Activated Kinase 1 (TAK1)-Bmding Proteins (TAB) 2 and 3 Negatively Regulate Autophagy2011

    • Author(s)
      Takaesu G, Kobayashi T, Yoshimura A
    • Journal Title

      J Biochem.

      Volume: 151 Issue: 2 Pages: 157-166

    • DOI

      10.1093/jb/mvr123

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] サイトカインシグナル抑制因子SOCSによるIgE産生の制御.2011

    • Author(s)
      小林隆志、飛彈野真也
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 56 Pages: 151-158

    • Related Report
      2011 Research-status Report
  • [Presentation] 本邦産Aedes (Stegomyia) scutellarisグループ蚊2種のチクングニアウイルス感受性(2)2014

    • Author(s)
      江下優樹, 福田昌子, Lucky Runtuwene, 大塚 靖, 野口香緒里, 川上絵理, 德永暁憲, 小林隆志, 服部正策, Raweewan Srisawat, Narumon Komalamisra, 牛島廣治, 倉根一郎, 高崎智彦
    • Organizer
      第66回日本衛生動物学会大会
    • Place of Presentation
      岐阜大学地域科学部、岐阜県岐阜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Utilization of CCL-125 for analyzing innate immunity in Aedes aegypti2014

    • Author(s)
      Lucky R. Runtuwene, Shuichi Kawashima, Kaori Noguchi, Eri Kawakami, Akinori Tokunaga, Yutaka Suzuki , Sumio Sugano, Kenta Nakai, Ryuichiro Maeda, Chihiro Sugimoto, Tomohiko Takasaki, Ichiro Kurane, Takashi Kobayashi and Yuki Eshita
    • Organizer
      第66回日本衛生動物学会大会
    • Place of Presentation
      岐阜大学地域科学部、岐阜県岐阜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] The effects of allergic rhinitis on mucosal immunity of the middle ear in B cell-specific SOCS1 deficient mice2013

    • Author(s)
      Kaori Noguchi, Toshiaki Kawano, Takashi Hirano, Yoshinori Kadowaki, Masashi Suzuki, Takashi Kobayashi
    • Organizer
      第42回日本免疫学会総会・学術集会
    • Place of Presentation
      千葉
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of the mucosal immune system of middle ear and nose in Suppressor of cytokine signaling (SOCS)-1 knockout mouse model with allergic rhinitis2013

    • Author(s)
      Toshiaki Kawano, Takashi Hirano, Yoshinori Kadowaki, Munehito Moriyama, Tarou Iwasaki, Kaori Noguchi, Takashi Kobayashi, Masashi Suzuki
    • Organizer
      The 7th Extraordinary International symposium on recent advances in otitis media
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2013 Final Research Report
  • [Presentation] 節足動物媒介性ウイルスの迅速検出へのRT-LAMP法の改良2013

    • Author(s)
      江下優樹,松原祥恵,Lucky R.Runtuwene,野口香緒里,川上絵理,大塚 靖,福田昌子,小林隆志,高崎智彦,Raweewan Srisawat,Narumon Komalamisra,Bouasy Hongvanthong,成田弘成,牛島廣治,Arthur E. Mongan,今田美穂子,前田龍一郎,森田公一,杉本千尋,倉根一郎
    • Organizer
      日本家屋害虫学会
    • Place of Presentation
      日本大学生物資源科学部、神奈川県藤沢市
    • Related Report
      2013 Annual Research Report
  • [Presentation] INOVATIVE TECHNOLOGY FOR USE IN VECTOR CONTROL2013

    • Author(s)
      Yuki Eshita, Lucky R. Runtuwene, Masako Fukuda, Yasushi Otsuka, Akinori Tokunaga, Takashi Kobayashi, Raweewan Srisawat, Bouasy Hongvanthong, Arthur E. Mongan, Josef Tuda, Mihoko Imada, Tomohiko Takasaki, Ichiro Kurane, et al.
    • Organizer
      The 1st conference on asian pediatric infectious diseases
    • Place of Presentation
      東京大学医学部3号館N101室、東京都文京区
    • Related Report
      2013 Annual Research Report
  • [Presentation] Comprehensive Gene Expression Analysis of Dengue-Infected Mosquitoes2013

    • Author(s)
      Lucky Runtuwene, Shuichi Kawashima, Kaori Noguchi, Eri Kawakami, Akinori Tokunaga, Yutaka Suzuki, Takashi Kobayashi, Yuki Eshita
    • Organizer
      The 1st conference on asian pediatric infectious diseases
    • Place of Presentation
      東京大学医学部3号館N101室、東京都文京区
    • Related Report
      2013 Annual Research Report
  • [Presentation] Comprehensive gene expression analysis of dengue-infected Aedes aegypti and novel anti-viral proteins in Aedes aegypti2013

    • Author(s)
      Lucky Runtuwene, Shuichi Kawashima, Kaori Noguchi, Eri Kawakami, Akinori Tokunaga, Junya Yamagishi, Mihoko Imada, Ryuichiro Maeda, Yutaka Suzuki, Takashi Kobayashi, Yuki Eshita
    • Organizer
      インドネシア国寄生虫会議セミナー
    • Place of Presentation
      インドネシア国マナド市サムラトランギ大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 本邦産Aedes (Stegomyia) scutellarisグループ蚊2種のチクングニアウイルス感受性2013

    • Author(s)
      江下優樹、福田昌子、Lucky Runtuwene、大塚 靖、野口香緒里、川上絵理、德永暁憲、小林隆志、服部正策、Raweewan Srisawat、Narumon Komalamisra、牛島廣治、倉根一郎、高崎智彦
    • Organizer
      第66回日本寄生虫学会南日本支部大会・第63回日本衛生動物学会南日本支部大会 合同大会
    • Place of Presentation
      大分県由布市、大分大学医学部臨床講義棟1F 臨床中講義室
    • Related Report
      2013 Annual Research Report
  • [Presentation] Potential novel anti-viral proteins in Aedes aegypti2013

    • Author(s)
      Lucky Runtuwene, Shuichi Kawashima, Kaori Noguchi, Eri Kawakami, Akinori Tokunaga, Yutaka Suzuki, Takashi Kobayashi, Yuki Eshita
    • Organizer
      第66回日本寄生虫学会南日本支部大会・第63回日本衛生動物学会南日本支部大会 合同大会
    • Place of Presentation
      大分県由布市、大分大学医学部臨床講義棟1F 臨床中講義室
    • Related Report
      2013 Annual Research Report
  • [Presentation] The effects of allergic rhinitis on mucosal immunity of the middle ear in B cell-specific SOCS1 deficient mice2013

    • Author(s)
      Kaori Noguchi, Toshiaki Kawano, Takashi Hirano, Yoshinori Kadowaki, Masashi Suzuki, Takashi Kobayashi
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ、千葉県千葉市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新規蛍光・化学発光プローブSuperSTAR遺伝子を用いた組織特的レポーターマウスの開発2012

    • Author(s)
      小林隆志,原央子,飛彈野真也,野口香緒里,中野雅裕,永井健治,岡野ジェイムス洋尚,岡野栄之
    • Organizer
      第35回日本分子生物学会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
    • Related Report
      2013 Final Research Report
  • [Presentation] IL-10受容体に結合する候補分子Zimp7の細胞内局在と機能の解析2012

    • Author(s)
      野口香緒里,佐藤翔太,石川天洋,徳永暁憲,小林隆志
    • Organizer
      第35回日本分子生物学会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulatory T cells specific TRAF6 deletion resulted in Th2 type inflammation2011

    • Author(s)
      Go Muto, Takashi Kobayashi, Akihiko Yoshimura
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      千葉幕張メッセ(千葉)
    • Year and Date
      2011-11-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of molecular mechanisms underlying hyper production of IgE in B cell-specific SOCS1 deficient mice2011

    • Author(s)
      Shinya Hidano, Akihiko Yoshimura, Takashi Kobayashi
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      千葉幕張メッセ(千葉)
    • Year and Date
      2011-11-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of molecular mechanisms underlying hyper production of IgE in B cell-specific SOCS1 deficient mice.2011

    • Author(s)
      Shinya Hidano, Akihiko Yoshimura, and Takashi Kobayashi
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2011 Research-status Report
  • [Presentation] Regulatory T cells specific TRAF6 deletion resulted in Th2 type inflammation.2011

    • Author(s)
      Go Muto, Takashi Kobayashi, Akihiko Yoshimura.
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2011 Research-status Report
  • [Presentation] 新規蛍光・化学発光プローブSuperSTAR遺伝子を用いた組織特的レポーターマウスの開発.

    • Author(s)
      小林 隆志, 原 央子, 飛彈野 真也, 野口 香緒里, 中野 雅裕, 永井 健治, 岡野 ジェイムス洋尚, 岡野 栄之
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡市
    • Related Report
      2012 Research-status Report
  • [Presentation] IL-10受容体に結合する候補分子Zimp7の細胞内局在と機能の解析.

    • Author(s)
      野口 香緒里, 佐藤 翔太, 石川 天洋, 徳永 暁憲, 小林 隆志
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡市
    • Related Report
      2012 Research-status Report
  • [Book] 臨床免疫・アレルギー科vol.56 (2), サイトカインシグナル抑制因子SOCSによるIgE産生の制御2011

    • Author(s)
      小林隆志、飛彈野真也
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.med.oita-u.ac.jp/idc/

    • Related Report
      2013 Final Research Report
  • [Remarks] 大分大学医学部感染予防医学講座のホームページ

    • URL

      http://www.med.oita-u.ac.jp/idc/index.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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