| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Research Abstract |
Signals from BCR and BAFF-R control the differentiation of mature B cells as well as their survival. In this research I investigated the roles of signals from BCR and BAFF-R in the differentiation of mature B cells and found that Akt, one of the target molecule of PI3 kinase, which transmits the survival signal from BCR plays an important role in B1 cell development and that the main function of the canonical NF-kappaB pathway in the generation of mature B2 and MZ B cells is the control of the strength of BAFF-R mediated alternative NF-kappaB signaling. I also examined the function of a novel ubiquitin ligase complex, LUBAC in B cells and discovered that LUBAC plays important roles in the development of B1 cells and the antibody responses and is required for the activation of the canonical NF-kappaB pathway by CD40 and TACI but not by BCR.
|
