| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
The attachment of oligosaccharide, at Asn297, of the IgG-Fc heavy chain is essential for optimal activation of Fc effector functions. It has recently been shown that IgG with oligosaccharides bearing terminal sialic acid residues mediates anti-inflammatory therapeutic effects. We expressed an IgG1 Phe243Ala (F243A) mutant in both human and rodent cell lines, and sialylation was found to be markedly increased. The mechanism by which the sialic acid residues in the IgG-Fc oligosaccharides exert an anti-inflammatory effect has been investigated by using dendritic cells that express DC-SIGN.
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