| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
The study examined a type and frequency of single nucleotide polymorphisms (SNPs) of the drug transporters which may contribute to the inter-individual variability of pharmacokinetics of gabapentin in healthy Japanese volunteers. Regarding with the unknown SNP of L-type amino acid transporter 2 (LAT2), absorption of gabapentin increased in two subjects homozygous for the common allele, four subjects heterozygous and one subject homozygous for the mutant allele in this order. Frequency of these genotypes were 22, 45 and 22%, respectively in 73 Japanese. The unknown SNPs of organic cation transporter 1 (OCTN1) and multidrug and toxin extrusion protein 1 (MATE1) found in one subject whose renal excretion of gabapentin was low, were not detected in this population.
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