Comprehensive study regarding adverse effects of opioid under palliative care
| Project/Area Number |
23590651
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NARITA Minoru 星薬科大学, 薬学部, 教授 (40318613)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | モルヒネ / 緩和医療 / 吐気 / 便秘 / 精神依存 / Morphine / オピオイド鎮痛薬 / 大腸輸送能 / 小腸輸送能 / 末梢性μ-opioid 受容体 / naloxonazine / naloxone methiodide / 吐き気 / オランザピン / 嘔気 / 嘔吐 / 疼痛治療 / 副作用 |
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| Outline of Final Research Achievements |
We found that olanzapine has beneficial profile to suppress opioid-induced emesis. This finding changes the strategy how opioid-induced emesis could be managed, and this change improve the patient's QOL. We also demonstrated that pirenzepine also suppressd opioid-induced emesis. Pirenzepine has much lessor adverse effects than those of olanzapine. Therefore, traials to investigate the effects of pirenzepine on opioid-induced emesis could be accepted in the Yokohana City University hospital.
We also demonstrated that morphine, oxycodone, and fentanyl induce constipation through different mechanisms, and these findings may help us to understand the characteristics of the constipation induced by each μ-opioid receptor agonist and improve the quality of life by reducing constipation in patients being treated for pain. In addition, we gave some information that opioid-induced psychic dependence could be established under chemotherapy-induced pain conditions.
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Report
(5 results)
Research Products
(56 results)
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[Journal Article] Establishment of opioid-induced rewarding effects under oxaliplatin- and Paclitaxel-induced neuropathy in rats.2014
Author(s)
Mori T, Kanbara T, Harumiya M, Iwase Y, Masumoto A, Komiya S, Nakamura A, Shibasaki M, Kanemasa T, Sakaguchi G, Suzuki T.
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Journal Title
J Pharmacol Sci.
Volume: 126
Pages: 47-55
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Orally active opioid μ/δ dual agonist MGM-16, a derivative of the indole alkaloid mitragynine, exhibits potent antiallodynic effect on neuropathic pain in mice.2014
Author(s)
Matsumoto K, Narita M, Muramatsu N, Nakayama T, Misawa K, Kitajima M, Tashima K, Devi LA, Suzuki T, Takayama H, Horie S.
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Journal Title
J Pharmacol Exp Ther.
Volume: 348
Issue: 3
Pages: 383-392
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] G protein-gated inwardly rectifying potassium (KIR3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites.2014
Author(s)
Nakamura A, Fujita M, Ono H, Hongo Y, Kanbara T, Ogawa K, Morioka Y, Nishiyori A, Shibasaki M, Mori T, Suzuki T, Sakaguchi G, Kato A, Hasegawa M.
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Journal Title
Br J Pharmacol.
Volume: 171
Issue: 1
Pages: 253-264
DOI
Related Report
Peer Reviewed
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[Journal Article] Usefulness of olanzapine as an adjunct to opioid treatment and for the treatment of neuropathic pain.2012
Author(s)
Torigoe K, Nakahara K, Rahmadi M, Yoshizawa K, Horiuchi H, Hirayama S, Imai S, Kuzumaki N, Itoh T, Yamashita A, Shakunaga K, Yamasaki M, Nagase H, Matoba M, Suzuki T, Narita M.
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Journal Title
Anesthesiology
Volume: 116
Pages: 159-169
Related Report
Peer Reviewed
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[Presentation] 薬物依存の研究 (第 484 報) ; Morphine 依存マウスの退薬症候における sigma-1 受容体の関与、大屋順平, 森友久, 鵜澤直生, 杉山紘一, 芝崎真裕, 鈴木勉2014
Author(s)
大屋順平, 森友久, 鵜澤直生, 杉山紘一, 芝崎真裕, 鈴木勉
Organizer
第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会合同年会
Place of Presentation
沖縄
Year and Date
2014-10-24 – 2014-10-26
Related Report
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[Presentation] モルヒネ身体依存時の退薬による下痢におけるフリーラジカル及びシグマ-1受容体の関与、大屋順平, 森友久, 鵜澤直生, 杉山紘一, 芝崎真裕, 鈴木勉2014
Author(s)
大屋順平, 森友久, 鵜澤直生, 杉山紘一, 芝崎真裕, 鈴木勉
Organizer
第33回 鎮痛薬・オピオイドペプチド研究会
Place of Presentation
神戸
Year and Date
2014-09-04 – 2014-09-05
Related Report
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[Presentation] オキシコドンとモルヒネの脳内における鎮痛作用発現メカニズムの違い2012
Author(s)
小野ひろ子, 中邨篤史, 藤田真栄, 本郷良泳, 蒲原智恵, 小川公一, 森岡靖英, 西依淳, 芝﨑真裕, 森友久, 鈴木勉, 阪口岳, 長谷川稔
Organizer
第22回日本臨床精神神経薬理学会 第42回日本神経精神薬理学会
Place of Presentation
栃木
Related Report
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