| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We found that olanzapine has beneficial profile to suppress opioid-induced emesis. This finding changes the strategy how opioid-induced emesis could be managed, and this change improve the patient's QOL. We also demonstrated that pirenzepine also suppressd opioid-induced emesis. Pirenzepine has much lessor adverse effects than those of olanzapine. Therefore, traials to investigate the effects of pirenzepine on opioid-induced emesis could be accepted in the Yokohana City University hospital.
We also demonstrated that morphine, oxycodone, and fentanyl induce constipation through different mechanisms, and these findings may help us to understand the characteristics of the constipation induced by each μ-opioid receptor agonist and improve the quality of life by reducing constipation in patients being treated for pain. In addition, we gave some information that opioid-induced psychic dependence could be established under chemotherapy-induced pain conditions.
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