| Project/Area Number |
23590653
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Yutaka 神戸女子大学, 健康福祉学部, 教授 (20388028)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 膵β細胞保護作用 / GPR39 / Pdx-1 / 亜鉛医薬品 / インスリン / 膵β細胞保護 / ＧＰＲ３９ / Ｐｄｘ－１ / 亜鉛錯体 |
|---|
| Research Abstract |
Zinc is one of the essential trace elements playing an important role in our life. From the recent studies of molecular biology, the zinc-homeostasis in the animal body has been found to be properly controlled by 22 kinds of zinc transporters. Concerning the Japanese aging of the population, lifestyle-related diseases as metabolic-syndromes mainly derived from obesity and type-2 diabetes are more urgent issues.
From these backgrounds, we have investigated the anti-diabetic action and effects of zinc closely related with insulin homeostasis and activity, and succeeded the development of several orally-active zinc complexes. In this study, first we focused to cure both the type 1 and type 2 diabetes on the basis of activatiing transpciption factor, Pdx-1, expressed in the pancreas. Secondly, we indicated the new positive results for both the biochemical and morphological analyses of dramatically improved pancreas and liver in zinc complex-treated type-2 diabetic KK-Ay mice.
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