Development of anti-diabetic zinc medicine protecting the pancreatic B cells through the GPR39-stimulating Pdx-1 expression
| Project/Area Number |
23590653
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Yutaka 神戸女子大学, 健康福祉学部, 教授 (20388028)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 膵β細胞保護作用 / GPR39 / Pdx-1 / 亜鉛医薬品 / インスリン / 膵β細胞保護 / ＧＰＲ３９ / Ｐｄｘ－１ / 亜鉛錯体 |
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| Research Abstract |
Zinc is one of the essential trace elements playing an important role in our life. From the recent studies of molecular biology, the zinc-homeostasis in the animal body has been found to be properly controlled by 22 kinds of zinc transporters. Concerning the Japanese aging of the population, lifestyle-related diseases as metabolic-syndromes mainly derived from obesity and type-2 diabetes are more urgent issues.
From these backgrounds, we have investigated the anti-diabetic action and effects of zinc closely related with insulin homeostasis and activity, and succeeded the development of several orally-active zinc complexes. In this study, first we focused to cure both the type 1 and type 2 diabetes on the basis of activatiing transpciption factor, Pdx-1, expressed in the pancreas. Secondly, we indicated the new positive results for both the biochemical and morphological analyses of dramatically improved pancreas and liver in zinc complex-treated type-2 diabetic KK-Ay mice.
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] The disposition and intestinal absorption of zinc in rats.2011
Author(s)
T. Yasuno, H. Okamoto, M. Nagai, S. Kimura, T. Yamamoto, K. Nagano, T. Furubayashi, Y. Yoshikawa, Hiroyuki Yasui, Hidemasa Katsumi, Toshiyasu Sakane, and Akira Yamamoto
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Journal Title
Eur. J. Pharm. Sci.
Volume: 44
Pages: 410-415
Related Report
Peer Reviewed
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[Journal Article] In vitro study on the transport of zinc across intestinal epithelial cells using Caco-2 monolayers and isolated rat intestinal membranes.2011
Author(s)
Tohru Yasuno, Hiroki Okamoto, Miho Nagai, Shunsuke Kimura, Takanori Yamamoto, Kozue Nagano, Tomoyuki Furubayashi, Yutaka yoshikawa, Hiroyuki Yasui, H. Katsumi, T. Sakane, and A. Yamamoto
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Journal Title
Biol. Pharm. Bull.
Volume: 35
Pages: 588-593
NAID
Related Report
Peer Reviewed
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[Presentation] 疾患メタロミクスと酸化ストレス2012
Author(s)
安井裕之, 伊賀瑞紗, 松尾岳志, 吉川豊, 中村任, 久米学, 江原正明, 福田浩之, 平岡勇二
Organizer
第65回日本酸化ストレス学会学術集会
Place of Presentation
徳島(シンポジウム講演)
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[Book] 序章,第1, 2, 3, 5, 6, 7, 8, 9, 10章.医薬品分析化学2013
Author(s)
安井裕之(黒田幸弘, 安井裕之, 吉川豊共著)
Total Pages
427
Publisher
京都廣川書店
Related Report
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[Book] 医薬品分析化学2013
Author(s)
黒田幸弘、安井裕之、吉川 豊 共著
Total Pages
427
Publisher
京都廣川書店
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