| Project/Area Number |
23590661
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Masami 群馬大学, 医学(系)研究科(研究院), 教授 (30241871)
KURABAYASHI Masahiko 群馬大学, 医学(系)研究科(研究院), 教授 (00215047)
NAKAHARA Takehiro 群馬大学, 医学部附属病院, 助教 (00599540)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 内科学 / 臨床検査医学 / 動脈硬化 / 生理機能 / バイオマーカー |
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| Research Abstract |
Each stage of atherosclerotic progression can be evaluated based on the results of three clinical vascular atherosclerosis-evaluating tests. In the initial stage, there is a low flow-mediated vasodilation level. In the intermediate atherosclerotic formation stage, there is a high cardioankle vascular index level. Finally, in the intima-media thickening stage, there is a high intima-media thickness level. To explore the optimal biomarkers reflecting each stage of atherosclerotic progression, these three tests and circulating biomarker measurements were performed in patients with lifestyle-related diseases, including diabetes mellitus. Each stage of atherosclerotic progression in subjects with lifestyle-related diseases, including diabetes, may reflect the initial stage if the uric acid or LDL-C level is high, the intermediate stage if the ICAM-1 level is high and the BAP or NOx level is low, and the intima-media thickening stage if the ICAM-1 level is high.
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