| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
We investigated whether hepatic lipase in post-heparin plasma could be a useful marker for diagnosing non-alcoholic steato hepatitis (NASH).Forty-two Argentines and thirty-one Japanese patients were involved in this study.
In Argentines, steatosis grade were classified into 3 grades and there were no significant differences in HL activities among the three groups. In Japanese patients, there was no difference in HL activities between subjects with and without NASH. These findings suggest that there is a limitation of applying HL activity as a method of reflecting HL. Alternatively we established a new enzyme-linked immunosorbent assay system for human HL protein mass. The correlation coefficients between alanine aminotransferase (ALT) and HL activity was 0.185(p<0.05) whereas those between ALT and HL mass was (0.285 p<0.01). This suggest that HL mass is superior to HL activity for detecting NASH.
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