Clinical significance of measuring lipolytic enzyme for predicting non-alcoholic steato hepatitis

• Project/Area Number: 23590663
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kanazawa Medical University (2012-2014); Kanazawa University (2011)
• Principal Investigator: KOBAYASHI Junji 金沢医科大学, 医学部, 教授 (60302577)
• Co-Investigator(Kenkyū-buntansha): OKADA Toshihide 金沢大学, 医学系, 特任教授 (20251944)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 肝性リパーゼ / 非アルコール性脂肪肝炎 / 抗ヒトHTGLモノクローナル抗体 / NASH / HTGL活性 / NAFLD Activity Scor / リポ蛋白リパーゼ / 高分子アディポネクチン

Outline of Final Research Achievements

We investigated whether hepatic lipase in post-heparin plasma could be a useful marker for diagnosing non-alcoholic steato hepatitis (NASH).Forty-two Argentines and thirty-one Japanese patients were involved in this study.
In Argentines, steatosis grade were classified into 3 grades and there were no significant differences in HL activities among the three groups. In Japanese patients, there was no difference in HL activities between subjects with and without NASH. These findings suggest that there is a limitation of applying HL activity as a method of reflecting HL. Alternatively we established a new enzyme-linked immunosorbent assay system for human HL protein mass. The correlation coefficients between alanine aminotransferase (ALT) and HL activity was 0.185(p<0.05) whereas those between ALT and HL mass was (0.285 p<0.01). This suggest that HL mass is superior to HL activity for detecting NASH.

Research Products

• [Journal Article] The effect of anagliptin treatment on glucose metabolism and lipid metabolism, and oxidative stress in fasting and postprandial states using a test meal in Japanese men with type 2 diabetes (2015)
  • Author(s): Kakuda H, Kobayashi J, Kakuda M, Yamakawa J, Takekoshi N
  • Journal Title: Endocrine Volume: 48 Issue: 3 Pages: 1005-1009
  • DOI: 10.1007/s12020-014-0376-x
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of the effect of post-heparin and pre-heparin lipoprotein lipase and hepatic triglyceride lipase on remnant lipoprotein metabolism (2015)
  • Author(s): Shirakawa T, Nakajima K, Shimomura Y, Kobayashi J, Stanhope K, Havel P, Machida T, Sumino H, Murakami M
  • Journal Title: Clinica Chimica Acta Volume: 440 Pages: 193-200
  • DOI: 10.1016/j.cca.2014.07.020
  • Peer Reviewed / Open Access
• [Journal Article] Autosomal Recessive Hypercholesterolemia: A Mild Phenotype of Familial Hypercholesterolemia: Insight from the Kinetic Study using Stable Isotope and Animal Studies (2015)
  • Author(s): Tada H, Kawashiri MA, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 22 Issue: 1 Pages: 1-9
  • DOI: 10.5551/jat.27227
  • NAID: 130004704376
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] The role of circulating lipoprotein lipase and adiponectin on the particle size of remnant lipoproteins in patients with diabetes mellitus and metabolic syndrome (2015)
  • Author(s): Shirakawa T, Nakajima K, Yatsuzuka SI, Shimomura Y, Kobayashi J, Machida T, Sumino H, Murakami M
  • Journal Title: Clinica Chimica Acta Volume: 440 Pages: 123-132
  • DOI: 10.1016/j.cca.2014.10.029
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of Coronary Atherosclerosis in Patients With Familial Hypercholesterolemia by Coronary Computed Tomography Angiography (2015)
  • Author(s): Tada H, Kawashiri MA, Okada H, Teramoto R, Konno T, Yoshimuta T, Sakata K, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M, Hayashi K.
  • Journal Title: Am J Cardiol. Volume: 115 Issue: 6 Pages: 724-729
  • DOI: 10.1016/j.amjcard.2014.12.034
  • Peer Reviewed / Open Access
• [Journal Article] 慢性疼痛に対する漢方治療 (2015)
  • Author(s): 山川淳一、守屋純二、小林淳二
  • Journal Title: 日本病院総合診療医学会雑誌 Volume: 7 Pages: 31-36
  • NAID: 40020321662
• [Journal Article] Nohara A, Kobayashi J , Kawashiri MA, Tada H, Inazu A, Jiang M, Mabuchi H, Bujo H. Clinical significance of measuring soluble LR11, a circulating marker of atherosclerosis and HbA1c in familial hypercholesterolemia (2014)
  • Author(s): Nohara A, Kobayashi J , Kawashiri MA, Tada H, Inazu A, Jiang M, Mabuchi H, Bujo H
  • Journal Title: Clinical Biochemistry Volume: 47 Issue: 13-14 Pages: 1326-1328
  • DOI: 10.1016/j.clinbiochem.2014.05.003
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of pancreatic endocrine function in patients with IgG4-related diseases, in whom autoimmune pancreatitis was ruled out by diagnostic imaging. (2014)
  • Author(s): Ito N, Yagi K, Kawano M, Mori Y, Okazaki S, Chujo D, Takeda Y, Kobayashi J, Yamagishi M
  • Journal Title: Endocr J Volume: 61 Pages: 765-772
  • Peer Reviewed
• [Journal Article] Genotypic and phenotypic features in homozygous familial hypercholesterolemia caused by proprotein convertase subtilisin/kexin type 9 (PCSK9) gain-of-function mutation (2014)
  • Author(s): Mabuchi H, Nohara A, Noguchi T, Kobayashi J, Kawashiri MA, Inoue T, Mori M, Tada H, Nakanishi C, Yagi K, Yamagishi M, Ueda K, Takegoshi T, Miyamoto S, Inazu A, Koizumi J; The Hokuriku FH Study Group
  • Journal Title: Atherosclerosis Volume: 236 Issue: 1 Pages: 54-61
  • DOI: 10.1016/j.atherosclerosis.2014.06.005
  • Peer Reviewed / Open Access
• [Journal Article] Antibodies to human angiopoietin-like protein 3: a patent evaluation of WO2012174178 (2014)
  • Author(s): Nakajima K, Kobayashi J
  • Journal Title: Expert Opin Ther Pat Volume: 24 Issue: 1 Pages: 113-119
  • DOI: 10.1517/13543776.2013.842555
  • Peer Reviewed
• [Journal Article] Significance of kampo, Japanese traditional medicine, in the treatment of obesity: basic and clinical evidence (2013)
  • Author(s): Yamakawa J, Moriya J, Takeuchi K, Nakatou M, Motoo Y, Kobayashi J
  • Journal Title: Evid Based Complement Alternat Med Volume: 2013 Pages: 1-8
  • DOI: 10.1155/2013/943075
  • Peer Reviewed
• [Journal Article] Impact of serum retinol-binding protein 4 levels on regulation of remnant-like particles triglyceride in type 2 diabetes mellitus (2013)
  • Author(s): Yamaaki N, Yagi K, Kobayashi J, Nohara A, Ito N, Asano A, Nakano K, Liu J, Okamoto T, Mori Y, Ohbatake A, Okazaki S, Takeda Y, Yamagishi M
  • Journal Title: J Diabetes Res Volume: 2013 Pages: 143515-143515
  • DOI: 10.1155/2013/143515
  • Peer Reviewed
• [Journal Article] A new enzyme-linked immunosorbent assay system for human hepatic triglyceride lipase (2013)
  • Author(s): Miyashita K, Kobayashi J, Imamura S, Kinoshita N, Stanhope KL, Havel PJ, Nakajima K, Machida T, Sumino H, Nara M, Murakami M
  • Journal Title: Clin Chim Acta Volume: 424 Pages: 201-206
  • DOI: 10.1016/j.cca.2013.06.016
  • Peer Reviewed
• [Journal Article] Significance of kampo, traditional Japanese medicine, in supportive care of cancer patients (2013)
  • Author(s): Yamakawa J, Motoo Y, Moriya J, Ogawa M, Uenishi H, Akazawa S, Sasagawa T, Nishio M, Kobayashi J
  • Journal Title: Evid Based Complement Alternat Med Volume: 2013 Pages: 1-10
  • DOI: 10.1155/2013/746486
  • Peer Reviewed
• [Journal Article] Role of kampo medicine in integrative cancer therapy (2013)
  • Author(s): Yamakawa J, Motoo Y, Moriya J, Ogawa M, Uenishi H, Akazawa S, Sasagawa T, Nishio M, Kobayashi J
  • Journal Title: Evid Based Complement Alternat Med Volume: 2013 Pages: 1-6
  • DOI: 10.1155/2013/570848
  • Peer Reviewed
• [Journal Article] Short-Term Effect of Pitavastatin Treatment on Glucose and Lipid Metabolism and Oxidative Stress in Fasting and Postprandial State Using a Test Meal in Japanese Men (2013)
  • Author(s): Kakuda,H, Kobayashi J, Nakato M, Takekoshi N
  • Journal Title: Cholesterol Volume: 2013 Pages: 1-7
  • DOI: 10.1155/2013/314170
  • Peer Reviewed
• [Journal Article] 再診、通院患者の病態別の診かた 脂質異常症 (2013)
  • Author(s): 野原 淳, 小林淳二
  • Journal Title: レジデント Volume: 6 Pages: 68-77
• [Journal Article] 脂質異常症の病因：リポ蛋白代謝酵素の観点から (2013)
  • Author(s): 小林淳二
  • Journal Title: 金沢医科大学雑誌 Volume: 38 Pages: 81-89
• [Journal Article] Diagnosis and Management of Type I and Type V Hyperlipoproteinemi (2012)
  • Author(s): Gotoda T
  • Journal Title: J Atheroscler Thromb Volume: 19 Pages: 1-12
  • Peer Reviewed
• [Journal Article] Altered metabolism of low-density lipoprotein and very-low-density lipoprotein remnant in autosomal recessive hypercholesterolemia : results from stable isotope kinetic study in vivo (2012)
  • Author(s): Tada H, Kawashiri MA, Ikewaki K, Terao Y, Noguchi T, Nakanishi C, Tsuchida M, Takata M, Miwa K, Konno T, Hayashi K, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M
  • Journal Title: Circ Cardiovasc Genet Volume: 5 Issue: 1 Pages: 35-41
  • DOI: 10.1161/circgenetics.111.960948
  • Peer Reviewed
• [Journal Article] Research Committee for Primary Hyperlipidemia, Research on Measures against Intractable Diseases by the Ministry of Health, Labour and Welfare in Japan. Management of type IIb dyslipidemia. (2012)
  • Author(s): Arai H
  • Journal Title: J Atheroscler Thromb Volume: 19 Pages: 105-114
  • Peer Reviewed
• [Journal Article] ackground to Discuss Guidelines for Control of Plasma HDL-Cholesterol in Japan (2012)
  • Author(s): Yokoyama S
  • Journal Title: J Atheroscler Thromb Volume: 19 Pages: 207-212
  • Peer Reviewed
• [Journal Article] Post-prandial remnant lipoprotein metabolism in autosomal recessive hypercholesterolaemia (2012)
  • Author(s): Tada H
  • Journal Title: Eur J Clin Invest Volume: 42 Issue: 10 Pages: 1094-1099
  • DOI: 10.1111/j.1365-2362.2012.02700.x
  • Peer Reviewed
• [Journal Article] Efficacy and safety of coadministration of rosuvastatin, ezetimibe, and colestimide in heterozygous familial hypercholesterolemia (2012)
  • Author(s): Kawashiri MA, Nohara A, Noguchi T, Tada H, Nakanishi C, Mori M, Konno T, Hayashi K, Fujino N, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M
  • Journal Title: Am J Cardiol Volume: 109 Issue: 3 Pages: 364-9
  • DOI: 10.1016/j.amjcard.2011.09.019
  • Peer Reviewed
• [Journal Article] Novel mutations of cholesteryl ester transfer protein(CETP) gene in Japanese hyperalphalipoproteinemic subjects (2012)
  • Author(s): Ohtani R, Inazu A, Noji Y, Wakasugi T, Miwa K, Tada H, Kawashiri MA, Noguchi T, Nohara A, Kobayashi J, Koizumi J, Yamagishi M, Mabuchi H
  • Journal Title: Clin Chim Acta Volume: 413 Issue: 5-6 Pages: 537-43
  • DOI: 10.1016/j.cca.2011.11.010
  • NAID: 120004026116
  • Peer Reviewed
• [Journal Article] Hokuriku FH Study Group. Molecular genetic epidemiology of homozygous familial hypercholesterolemia in the Hokuriku district of Japan (2011)
  • Author(s): Mabuchi H, Nohara A, Noguchi T, Kobayashi J, Kawashiri MA, Tada H, Nakanishi C, Mori M, Yamagishi M, Inazu A, Koizumi J
  • Journal Title: Atherosclerosis Volume: 214 Issue: 2 Pages: 404-407
  • DOI: 10.1016/j.atherosclerosis.2010.11.005
  • Peer Reviewed
• [Journal Article] Impact of bezafibrate and atorvastatin on lipoprotein subclass in patients with type III hyperlipoproteinemia : result from a crossover study (2011)
  • Author(s): Kawashiri MA, Kobayashi J, Nohara A, Noguchi T, Tada H, Nakanishi C, Inazu A, Mabuchi H, Yamagishi M
  • Journal Title: Clin Chim Acta Volume: 412 Issue: 11-12 Pages: 1068-75
  • DOI: 10.1016/j.cca.2011.02.026
  • Peer Reviewed
• [Journal Article] Postprandial lipoprotein metabolism: VLDL vs chylomicrons (2011)
  • Author(s): Nakajima K, Nakano T, Tokita Y, Nagamine T, Inazu A, Kobayashi J, Mabuchi H, Stanhope KL, Havel PJ, Okazaki M, Ai M, Tanaka A
  • Journal Title: Clin Chim Acta Volume: 412 Issue: 15-16 Pages: 1306-1318
  • DOI: 10.1016/j.cca.2011.04.018
  • Peer Reviewed
• [Journal Article] Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 and adipocytokine levels in dyslipidemic subjects with impaired glucose tolerance or type 2 diabetes mellitus : results from a crossover study (2011)
  • Author(s): Noguchi T, et al., 計14名、9番目
  • Journal Title: Atherosclerosis Volume: 217 Issue: 1 Pages: 165-170
  • DOI: 10.1016/j.atherosclerosis.2011.02.012
  • NAID: 120003141452
  • Peer Reviewed
• [Journal Article] A novel type of familial hypercholesterolemia : double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene (2011)
  • Author(s): Tada H, Kawashiri MA, Ohtani R, Noguchi T, Nakanishi C, Konno T, Hayashi K, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M
  • Journal Title: Atherosclerosis Volume: 219 Issue: 2 Pages: 663-6
  • DOI: 10.1016/j.atherosclerosis.2011.08.004
  • NAID: 120003368152
  • Peer Reviewed
• [Presentation] A new enzyme-linked immunosorbent assay system for human hepatic triglyceride lipase (2014)
  • Author(s): Kobayashi J, Miyashita K, Imamura S, Kinoshita N, Stanhope KL, Havel PJ, Nakajima K, Machida T, Sumino H, Nara M, Murakami M.
  • Organizer: The 2nd World Congress of Clinical Lipidology
  • Place of Presentation: ウィーン オーストリア
  • Year and Date: 2014-12-05 – 2014-12-07
• [Presentation] 新たなヒト肝性リパーゼ（HTGL）蛋白量測定法の確立 (2014)
  • Author(s): 小林淳二
  • Organizer: 第61回日本臨床検査医学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2014-11-25
• [Presentation] Genotypic and phenotypic features in homo- and heterozygous familial hypercholesterolemia(FH) caused by‘ FH gene’ mutations (2014)
  • Author(s): Mabuchi H, Nohara A, Noguchi T, Kobayashi J, Kawashiri M, Inoue T, Mori M, Tada H, Nakanishi C, Yagi K, Yamagishi M, Inazu A, Koizumi J
  • Organizer: 第46回日本動脈硬化学会総会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] 食後高脂血症におけるLDL- コレステロールの変動とsmall dense LDL との関係 (2014)
  • Author(s): 前田 俊彦、小林 淳二、竹越 襄
  • Organizer: 第46回日本動脈硬化学会総会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] 2 型糖尿病における選択的DPP-4 阻害薬アナグリプチンの食後代謝に及ぼす影響 (2014)
  • Author(s): 角田 弘一、小林 淳二、山川 淳一、竹越 襄
  • Organizer: 第46回日本動脈硬化学会総会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] 腹部肥満は代謝異常による慢性腎臓病の発症を助長する (2014)
  • Author(s): 小林 淳二、櫻井 勝、竹田 康男、長澤 晋哉、赤澤 純代、上西 博章、山川 淳一、守屋 純二、馬渕 宏、中川 秀昭
  • Organizer: 第46回日本動脈硬化学会総会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] 血中に存在するリポ蛋白リパーゼの80％以上がレムナントに結合して存在する (2014)
  • Author(s): 中嶋 克行、宮下かずや、小林 淳二、白川 尚史、下村洋之助、町田 哲男、角野 博之、村上 正巳
  • Organizer: 第46回日本動脈硬化学会総会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] Abdominal obesity, metabolic syndrome, and the risk of chronic kidney disease in Japanese males and female (2014)
  • Author(s): Sakurai M, Kobayashi J, Takeda Y, Nagasawa S, Yamakawa J, Moriya J, Mabuchi H, Nakagawa H
  • Organizer: 第74回米国糖尿病学会議（ADA)
  • Place of Presentation: サンフランシスコ USA
  • Year and Date: 2014-06-13 – 2014-06-17
• [Presentation] テストミール負荷後の糖・脂質代謝異常に対するDPP4阻害薬アナグリプチンの効果の検討 (2014)
  • Author(s): 角田弘一、小林淳二
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2014-05-23
• [Presentation] Changes in the frequency of the metabolic syndrome in Kanazawa city during the past 5 years (2012)
  • Author(s): Junji Kobayashi, Yasuo Takeda, Masakazu Yamagishi, Nobu Koyama,
  • Organizer: 第76回日本循環器学会総会
  • Place of Presentation: マリンメッセ福岡（福岡県）
• [Presentation] Altered Metabolism of Post-prandial Remnant Lipoprotein Fractions in Autosomal Recessive Hypercholesterolemia (2011)
  • Author(s): Tada H, Kawashiri MA, Nakano T, Nakajima K, Nakanishi C, Tsubokawa T, Konno T, Hayashi K, Uchiyama K, Nohara A, Fujino N, Ino H, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M
  • Organizer: The 84th American Heart Association 2011 Scientific Sessions
  • Place of Presentation: Orange County Convention Centre(USA)
• [Presentation] A Novel Type of Homozygous Familial Hypercholesterolemia：Double Heterozygous Mutations in LDL Receptor and LDL Receptor Adaptor Protein 1 gene (2011)
  • Author(s): Tada H, Kawashiri MA, Nakanishi C, Hodatsu A, Mori M, Tsubokawa T, Konno T, Hayashi K, Uchiyama K, Nohara A, Fujino N, Ino H, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M
  • Organizer: The 84th American Heart Association 2011 Scientific Session
  • Place of Presentation: Orange County Convention(USA)
• [Presentation] Lack of Association between Common p.T111I Variant in the Endothelial Lipase Gene and the Risk for Coronary Artery Disease in Familial Hypercholesterolemia: Insights from the Modulation of Phospholipids in the HDL Particles (2011)
  • Author(s): Tada H, Kawashiri MA, Nakanishi C, Hodatsu A, Mori M, Tsubokawa T, Konno T, Hayashi K, Uchiyama K, Nohara A, Fujino N, Ino H, Inazu A, Kobayashi J, Mabuchi H
  • Organizer: The 84th American Heart Association 2011 Scientific Session
  • Place of Presentation: Orange County Convention(USA)
• [Presentation] Impact of Impaired LDL Catabolism and Increased VLDL and VLDL Remnant Production on Hypercholesterolemia in Homozygous (2011)
  • Author(s): Kawashiri MA, Ikewaki K, Tada H, Noguchi T, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M
  • Organizer: The 84th American Heart Association 2011 Scientific Session
  • Place of Presentation: Orange County Convention(USA
• [Presentation] メタボリックシンドローム頻度の推移
  • Author(s): 小林淳二
  • Organizer: 第55回日本老年医学会
  • Place of Presentation: 大阪国際会議場(大阪府大阪市)
• [Presentation] インピーダンス法で測定した体組成指標と体格指数（BMI）との相関性
  • Author(s): 山本千勢、山本香代、中川明彦、古屋大祐、小林淳二
  • Organizer: 第31回日本肥満症治療学会
  • Place of Presentation: 学術総合センター (東京都千代田区)
• [Presentation] 健康管理センター受診者における栄養指導の有無とBMI、その他検査値に関する分析
  • Author(s): 山本香代、山本千勢、中川明彦、小林淳二、古屋大祐
  • Organizer: 第31回日本肥満症治療学会
  • Place of Presentation: 学術総合センター (東京都千代田区)
• [Presentation] 食後高脂血症と動脈硬化
  • Author(s): 小林淳二
  • Organizer: 第45回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル(東京都新宿区）
  • Invited
• [Presentation] ピタバスタチンの食後代謝への影響
  • Author(s): 角田弘一、小林淳二、中藤未央、竹越 嚢
  • Organizer: 第45回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル(東京都新宿区）
• [Presentation] 新たなヒト肝性リパーゼ蛋白量測定法の確立
  • Author(s): 宮下かずや、小林淳二、今村茂行、木下憲明、中嶋克行、町田哲男、角野博之、奈良誠人、村上正巳
  • Organizer: 第34回日本肥満学会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区）
• [Presentation] 企業健診者を対象とした栄養指導希望者と非希望者の分析
  • Author(s): 山本香代、山本千勢、中川明彦、中西由美子、小林淳二
  • Organizer: 第34回日本肥満学会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区）
• [Presentation] 代謝異常集積と慢性腎臓病の関連に及ぼす腹部肥満の影響
  • Author(s): 櫻井勝、小林淳二、竹田康男、長澤晋也、山川淳一、守屋純二、馬渕宏、中川秀昭
  • Organizer: 第34回日本肥満学会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区）
• [Presentation] ＩｇＡ／ＩｇＧ２欠損症を合併したリポ蛋白リパーゼ欠損症の１例
  • Author(s): 中林玄一、西田直徳、渡辺祐樹、伊藤靖典、足立雄一、野原淳、小林淳二
  • Organizer: 日本小児脂質研究会
  • Place of Presentation: 福井商工会議所(福井県福井市h）
• [Presentation] 代謝異常集積と慢性腎臓病の関連に及ぼす腹部肥満の影響
  • Author(s): 小林淳二、櫻井勝、竹田康男、長澤晋哉、赤澤純代、上西博章、山川淳一、守屋純二、馬渕宏、中川秀昭
  • Organizer: 第8回日本病院総合診療医学会学術集会
  • Place of Presentation: 大阪大学中之島センター(大阪府大阪市）
• [Presentation] Changes in the frequency of the metabolic syndrome (MS) in Kanazawa city during the past 5 years
  • Author(s): 小林淳二
  • Organizer: 第44回日本動脈硬化学会総会
  • Place of Presentation: 福岡ヒルトンシーホーク(福岡県)
• [Presentation] 非アルコール性脂肪肝（NAFLD）における、肝線維化マーカーとアディポネクチン、リポ蛋白代謝酵素との関係について
  • Author(s): 小林淳二
  • Organizer: 第23回日本臨床化学会東海北陸支部総会 第31回日本臨床検査医学会東海北陸支部総会
  • Place of Presentation: 富山国際会議場（富山県）
• [Presentation] 漢方治療より西洋医学的治療を優先すべきであった3症例
  • Author(s): 中藤未央
  • Organizer: 第３回 日本プライマリケア連合学会学術大会
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] メタボリックシンドローム該当者の頻度の推移
  • Author(s): 小林淳二
  • Organizer: 第33回日本肥満学会総会
  • Place of Presentation: 京都グランヴィア（京都府）
• [Presentation] メタボリックシンドローム該当者の頻度の推移
  • Author(s): 守屋純二
  • Organizer: 第6回 日本病院総合診療医学会学術総会
  • Place of Presentation: 長良川国際会議場（岐阜県）
• [Book] 臨床に直結する血栓止血学 (2013)
  • Author(s): 小林淳二
  • Total Pages: 381
  • Publisher: 中外医学社（東京）