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Clinicopathological study on adenocarcinoma of gastric phenotype and its precursor lesion

Research Project

Project/Area Number 23590664
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionShinshu University

Principal Investigator

OTA Hiroyoshi  信州大学, 医学部, 教授 (50273107)

Co-Investigator(Kenkyū-buntansha) OKUMURA Nobuo  信州大学, 医学部, 教授 (60252110)
HONDA Takayuki  信州大学, 医学部, 教授 (80238815)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords膵管内乳頭粘液性腫瘍 / 膵腫瘍 / 粘液 / mucin / TFF
Research Abstract

Pancreatic intraductal papillary mucinous neoplasms (IPMNs) are mucin-producing
neoplasms of the main and/or branch pancreatic ducts. To assess differences between various IPMN subtypes, immunohistochemical markers of gastrointestinal cells were evaluated in 33 surgically treated IPMNs. IPMNs into gastric (n=17), intestinal (n=8) and mixed gastric and intestinal type (collision=7, composite=1). No differences in age or sex were observed among these types. Gastric pyloric and small intestinal differentiation are characteristic of gastric and intestinal type IPMN, respectively, and these two IPMN types may have distinct pathogenesis.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (4 results)

All 2014 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] Reappraisal of the Immunophenotype of Pancreatic Intraductal Papillary Mucinous Neoplasms (IPMNs)—Gastric Pyloric and Small Intestinal Immunophenotype Expression in Gastric and Intestinal Type IPMNs—2014

    • Author(s)
      Mikiko Kobayashi, Yasunari Fujinaga and Hiroyoshi Ota
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 47 Issue: 2 Pages: 45-57

    • DOI

      10.1267/ahc.13027

    • NAID

      130003390847

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of primary signet-ring cell/histiocytoid carcinoma of the eyelid: immunohistochemical comparison with the normal sweat gland and review of the literature.2012

    • Author(s)
      Iwaya M, Uehara T, Yoshizawa A, Kobayashi Y, Momose M, Honda T, Ota H.
    • Journal Title

      Am J Dermatopathol

      Volume: 34 Issue: 8 Pages: e139-e145

    • DOI

      10.1097/dad.0b013e3182590ec1

    • NAID

      120007110588

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 眼瞼Hstiocytoid carcinoma/signet ring cell carcinomaの一症2011

    • Author(s)
      岩谷舞、佐野健司、太田浩良
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] 特別講演『ヒト組織におけるムチンコア蛋白 (MUC) の発現:正常分布とその病理診断への応用』

    • Author(s)
      太田浩良
    • Organizer
      第25回北陸病理集談会特別講
    • Place of Presentation
      福井大学医学部
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2011-08-05   Modified: 2019-07-29  

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