| Project/Area Number |
23590675
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
西山 佳宏 香川大学, 医学部, 教授 (50263900)
山本 由佳 香川大学, 医学部付属病院, 講師 (30335872)
飯田 秀博 独立行政法人国立循環器病研究センター研究所, 先進医工学センター画像診断医学部, 部長 (30322720)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脳虚血 / 脳血管容積 / 脳血流 / 脳酸素代謝量 / 脳酸素摂取率 / PET検査 / 脳血液量 / PET / 迅速検査法 / 酸素摂取率 / 脳梗塞 / 迅速検査 / 画像解析 / ＰＥＴ / 標識酸素 |
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| Research Abstract |
PET with 15O-labeled tracers is capable of providing crucial information in patients with cerebro-vascular disorders. DBFM method, allowing an extremely shortened examination period of <10 min scan time, was developed for CBF, OEF and CMRO2. The method misses CBV due to elimination of C15O scan. This study was intended to develop a improved technique for CBV. Validity was tested by comparing CBV values in normal (n=43) and patient subjects (n=45). The obtained CBV values in normal subject was 0.041+/-0.023 and in patient was 0.036+/-0.014, those were not significantly different to the conventional method. Regional contrast showed tight correlation, i.e., r=0.90 for normal and r=0.91 for patient. The obtained images were similar between the methods. The present method is of use to assess CBV.
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