Cerebral blood volume computation using single PET scan data with sequentially administrated 15O2 and H215O
| Project/Area Number |
23590675
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | Kagawa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
西山 佳宏 香川大学, 医学部, 教授 (50263900)
山本 由佳 香川大学, 医学部付属病院, 講師 (30335872)
飯田 秀博 独立行政法人国立循環器病研究センター研究所, 先進医工学センター画像診断医学部, 部長 (30322720)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 脳虚血 / 脳血管容積 / 脳血流 / 脳酸素代謝量 / 脳酸素摂取率 / PET検査 / 脳血液量 / PET / 迅速検査法 / 酸素摂取率 / 脳梗塞 / 迅速検査 / 画像解析 / ＰＥＴ / 標識酸素 |
|---|
| Research Abstract |
PET with 15O-labeled tracers is capable of providing crucial information in patients with cerebro-vascular disorders. DBFM method, allowing an extremely shortened examination period of <10 min scan time, was developed for CBF, OEF and CMRO2. The method misses CBV due to elimination of C15O scan. This study was intended to develop a improved technique for CBV. Validity was tested by comparing CBV values in normal (n=43) and patient subjects (n=45). The obtained CBV values in normal subject was 0.041+/-0.023 and in patient was 0.036+/-0.014, those were not significantly different to the conventional method. Regional contrast showed tight correlation, i.e., r=0.90 for normal and r=0.91 for patient. The obtained images were similar between the methods. The present method is of use to assess CBV.
|
Report
(4 results)
Research Products
(23 results)
-
-
-
-
-
-
-
-
-
[Journal Article] Quantitative assessment of regional cerebral blood flow by dynamic susceptibility contrast-enhanced MRI, without the need for arterial blood signals2012
Author(s)
Enmi J, Kudomi N, Hayashi T, Yamamoto A, Iguchi S, Moriguchi T, Hori Y, Koshino K, Zeniya T, Jon Shah N, Yamada N, Iida H
-
Journal Title
Phys Med Biol
Volume: 57
Pages: 7873-92
Related Report
-
[Journal Article] Quantitative assessment of regional cerebral blood flow by dynamic susceptibility contrast-enhanced MRI, without the need for arterial blood signals.2012
Author(s)
Enmi J, Kudomi N, Hayashi T, Yamamoto A, Iguchi S, Moriguchi T, Hori Y, Koshino K, Zeniya T, Jon Shah N, Yamada N, Iida H.
-
Journal Title
Phys Med Biol.
Volume: 57
Issue: 23
Pages: 7873-7892
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
