| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
Helicobacter pylori associated ITP were caused by H.pylori infection,we suggested that immunocomplex of platelets, H. pylori outer membrane protein (Hp-OMP) and anti Hp-OMP antibody were involved in pathogenic mechanisms of H. pylori associated ITP.
In this study, Hp-OMP has platelet agglutinating capacity, but the platelet aggregation-related factor of leukocytes may be involved. Although many of H. pylori strains have HpOMP,we thought that part of patients of H. pylori associated ITP have been affected by HpOMP. H. pylori associated ITP model was not able to reappear by an animal experiment. It was suggested that the mechanism of H.pylori related ITP development of symptoms is participating in each host immune system intricately.
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