Elucidate the platelet aggregation and the platelet associated diseases developing mechanism of the Helicobacter pylori outer membrane
| Project/Area Number |
23590677
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kochi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEUCHI Hiroaki 高知大学, 教育研究部医療学系, 講師 (90346560)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | Helicobacter pylori / 特発性血小板減少性紫斑病 / H. pylori菌体膜蛋白 / 抗原抗体複合体 / 血小板 / 血小板凝集 |
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| Research Abstract |
Helicobacter pylori associated ITP were caused by H.pylori infection,we suggested that immunocomplex of platelets, H. pylori outer membrane protein (Hp-OMP) and anti Hp-OMP antibody were involved in pathogenic mechanisms of H. pylori associated ITP.
In this study, Hp-OMP has platelet agglutinating capacity, but the platelet aggregation-related factor of leukocytes may be involved. Although many of H. pylori strains have HpOMP,we thought that part of patients of H. pylori associated ITP have been affected by HpOMP. H. pylori associated ITP model was not able to reappear by an animal experiment. It was suggested that the mechanism of H.pylori related ITP development of symptoms is participating in each host immune system intricately.
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Report
(4 results)
Research Products
(35 results)
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[Presentation] ミックス粉に繁殖するダニによるアナフィラキシーについてのアンケート結果について-当科で経験した3症例とともに報告する-2013
Author(s)
長尾佳樹, 大石拓, 寺内芳彦, 森本徳仁, 菊池広朗, 満田直美, 玉木渉, 山本雅樹, 堂野純孝, 久川浩章, 荒川良, 是永正敬, 藤枝幹也
Organizer
第50回日本小児アレルギー学会
Place of Presentation
パシフィコ横浜会議センター(横浜)
Related Report
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[Presentation] rep-PCRを原理とした細菌タイピングシステムDiversiLabによるHelicobacter pyloriのgenotyping2011
Author(s)
森本徳仁, 竹内啓晃, 森澤美恵, 西田愛恵, 吉川智絵, 森本みゆき, 森田珠恵, 門田陽集, 杉本千鶴子, 公文義雄, 小倉克巳, 近藤孝美, 杉浦哲朗
Organizer
日本臨床検査自動化学会第43回大会
Place of Presentation
パシフィコ横浜(横浜)
Related Report
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