Identification of novel gastric cancer risk markers
| Project/Area Number |
23590682
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
MAEKITA TAKAO 和歌山県立医科大学, 医学部, 講師 (10326358)
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| Co-Investigator(Kenkyū-buntansha) |
ICHINOSE Masao 和歌山県立医科大学, 医学部, 教授 (50143425)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | エピジェネティクス / 胃癌 / リスクマーカー / エピジェネテイック / メチル化 / 胃がん / ヘリコバクター・ピロリ / 萎縮性胃炎 / エピジェネティック / エピジェネティッ ク / DNAメチル化異常 / H. pylori |
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| Outline of Final Research Achievements |
This study aimed to elucidate the correlation between altered mucosal DNA methylation levels and activity of H. pylori-related gastritis, because inflammatory activity are associated with the development of diffuse-type gastric cancer. Methylation levels (promoter CpG islands (FLNc,HAND1, THBD, p41ARC, HRASLS, and LOX) and the CpG sites of non-coding repetitive elements (Alu and Sata) were examined by real-time methylation-specific PCR or bisulfite pyrosequencing. Methylation levels of the six CpG islands were consistently increased, and those of the two repetitive elements were consistently decreased in a stepwise manner with the activity of gastric inflammation. The observed correlation between altered DNA methylation levels and activity of H. pylori-related gastritis appears to be one of the relevant molecular mechanisms underlying the development of diffuse-type cancer.
We might identify novel diffuse-type gastric cancer risk marker.
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Report
(5 results)
Research Products
(2 results)
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[Journal Article] Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori-related gastritis2013
Author(s)
Yoshida T, Kato J, Maekita T, Yamashita S, Enomoto S, Ando T, Niwa T, Deguchi H, Ueda K, Inoue I, Iguchi M, Tamai H, Ushijima T, Ichinose M.
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Journal Title
Gastric Cancer
Volume: 16(4)
Issue: 4
Pages: 488-497
DOI
NAID
Related Report
Peer Reviewed
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