| Project/Area Number |
23590688
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHTSUKA Kouki 杏林大学, 医学部, 助手 (70439165)
OHNISHI Hiroaki 杏林大学, 医学部, 准教授 (80291326)
WATANABE Takashi 杏林大学, 医学部, 教授 (00191768)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 微生物 / 抗酸菌 / 遺伝子 / 感受性 / 新菌種 / mycobacterium kyorinense / 非結核性抗酸菌 / mycobacterium celatum / 全ゲノム解析 / 薬剤耐性 / rpoB / Mycobacterium kyorinense / 非定型抗酸菌 / 同定不能菌 |
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| Outline of Final Research Achievements |
The genetic analysis of 14 collected strains of Mycobacterium kyorinense clarified that they harbored polymorphism in 16S rRNA, suggesting the genetic diversity among the strains of this organism. In addition, analysis of Mycobacterium celatum, a species closely related to M. kyorinense, revealed that the sequences of several housekeeping genes of M. celatum type 2 are identical to those of M. kyorinense; therefore, we propose reclassification of M. celatum type 2 as M. kyorinense. Furthermore, the whole genome analysis of the type strain of M. kyorinense suggested that the mechanism underlying the resistance to antibiotics of this organism is significantly different from those of M. tuberculosis.
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