HHV-6 species specific serological assay
| Project/Area Number |
23590693
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Fujita Health University |
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Principal Investigator |
HIGASHIMOTO Yuki 藤田保健衛生大学, 医学(系)研究科(研究院), 研究員 (20569701)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Etsushi 藤田保健衛生大学, 医学部, 教授 (80288472)
IHIRA Masaru 藤田保健衛生大学, 医療科学部, 教授 (10290165)
ENOMOTO Yoshihiko 藤田保健衛生大学, 医学系研究科, 研究員 (00387713)
SUGIYAMA Hiroko 藤田保健衛生大学, 医学系研究科, 研究員 (10387714)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 臨床検査医学 / 小児科学 / ウイルス学 / 病態検査学 / 国際情報交換 / 臨床検査学 / 米国 / ザンビア / 国際情報交流 |
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| Research Abstract |
HHV-6 is divided into two species; HHV-6A and HHV-6B. Primary HHV-6B infection causes exanthem subitum (ES) that is common infectious disease in childhood. In contrast to HHV-6B, epidemiology and clinical feature of HHV-6A infection remains unclear because of no species-specific serological assay. To elucidate full-spectrum of HHV-6A infection, we sought to develop species-specific HHV-6 serological assay.
We have developed a new immunoblot assay that could discriminate between HHV-6A and B antibodies. However, this method is inappropriate for high-throughput analysis. Then, we tried to use synthesized peptides located within the target regions. Two peptide will be able to use ELISA for species-specific ELISA assays.
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Report
(4 results)
Research Products
(10 results)
