Developments of diagnostics for Mild Cognitive Impairment by patients serum and inhibition of the disease progress with vitamin D
| Project/Area Number |
23590697
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUENAGA Midori 徳島文理大学, 薬学部, 助教 (00389181)
坪井 義夫 福岡大学, 医学部, 教授 (90291822)
上原 吉就 福岡大学, 医学部, 講師 (70373149)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUBOI Yoshio 福岡大学, 医学部, 教授 (90291822)
UEHARA Yoshinari 福岡大学, 医学部, 講師 (70373149)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | アルツハイマー病 / アミロイドベータ蛋白 / ベータシート構造 / オリゴマー形成 / 蛋白凝集 / ビタミンＤ２ / ビタミンＤ３ / プリオン蛋白 / ベータシート形成 / 脳内蛋白異常凝集 / アルツハイマー病診断 / アルツハイマー病患者血清 / 蛋白加温修飾 / アミロイドベータ蛋白特異抗体 |
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| Research Abstract |
Aggregated amyloid-beta is a pathological feature in Alzheimer's disease(AD) and mild cognitive impairment(MCI) is an early stage of AD. Up to date, there is no diagnostics of MCI by patients serum. We found that the concentration of 25(OH)V-D3 in serum with MCI is lower than that of normal volunteers, and there is no differences in the concentration of 1,25(OH)2V-D3 between them. We suggest that the serum concentration of 25(OH)V-D3 is useful for the diagnostics of MCI. Unexpectedly, 25(OH)V-D3 showed no inhibitory effects for the aggregation in vitro, and rather promoted the aggregation.
PrPsc is the responsible protein to cause scrapie, which derived from the conformational transition of PrPc in normal brain. Oligomerization of PrPc is a pre-stage of PrPsc. We found that V-D3 could not break the oligomerization, however VD2 could break the oligzation, suggesting that VD2 is useful for scrapie therapy.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] MDR1 C3435T polymorphism and interaction wi h environmental factors in risk o Parkinson's disease : a case-con rol study in Japan2013
Author(s)
Kiyohara C, Miyake Y, Koyanagi, M. Fujimoto T, Shirasawa S, Tanaka K, Fukushima W, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae Fukuoka Kinki Parkinson's Disea e Study Group
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Journal Title
Drug Metab. Pharmacokinet
Volume: 28
Pages: 138-143
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[Journal Article] Concise synthesis of a probe molecule enabling analysis and imaging of vizantin2013
Author(s)
H.Yamamoto, M. Oda, M. Nakano, K. Yabuki, M. Shibutani, T. Nakanishi, M. Suenaga, M. Inoue, H. Imagawa, M. Nagahama, Y. Matsunaga, s. Himeno, K. Setsu, J. Sakurai,M. Nishizawa et al.
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Journal Title
Chem. Pharm. Bull.
Volume: 61
Pages: 452-459
NAID
Related Report
Peer Reviewed
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[Journal Article] Chemical and genetic diversity of Ligularia virgaurea collected in northern Sichuan and adjacent areas of China. Isoration of 13 new compounds2012
Author(s)
Saito Y, Takashima Y, Kamada A, Suzuki Y, Suenaga M, Okamoto Y, Matsunaga Y , Hanai R, Kawahara T, Gong X, Tori M
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Journal Title
Tetrahedron
Volume: 68
Pages: 10011-10029
Related Report
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[Journal Article] UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan2012
Author(s)
Miyake Y, Tanaka K, Fukushima W Kiyohara C, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, Study Group TF
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Journal Title
BMC Neurol
Volume: 12
Pages: 62-62
Related Report
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[Journal Article] SNCA polymorphisms, smoking, and sporadic Parkinson's disease in Japanese2012
Author(s)
Miyake Y, Tanaka K, Fukushima W, Kiyohara C, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M; Fukuoka Kinki Parkinson's Disease Study Group
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Journal Title
Parkinsonism Relat. Disord
Volume: 18
Pages: 557-561
Related Report
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[Journal Article] Refractory acute disseminated encephalomyelitis with anti-galactocerebroside antibody2012
Author(s)
Samukawa M, Hirano M, Tsugawa J, Sakamoto H, Tabata E, Takada K, Kuwahara M, Suzuki S, Kitada M, Yamada T, Hara H, Tsuboi Y, Nakamura Y, Kusunoki S
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Journal Title
Neurosci. Res
Volume: 74
Pages: 284-289
Related Report
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[Journal Article] Chemical and genetic diversity of Ligularia virgaurea collected in north Shichuan and adjacent areas of China. Isolation of 13 new compounds2012
Author(s)
Y. saito, Y. Takashima, A. Kamada, Y. Suzuki, M. Suenaga, Y. Okamoto, Y. Matsunaga, R. Hanai, T. Kawahara, X. Gong, M. Tori
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Journal Title
Tetrahedron
Volume: 68
Pages: 10011-10029
Related Report
Peer Reviewed
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