Research Project
Grant-in-Aid for Scientific Research (C)
High-density lipoprotein (HDL) has anti-atherogenic properties. Capillary isotachophoresis (cITP) separates plasma lipoproteins into 3 HDL subfractions and 3 LDL subfractions. In the present study, first, we show that that cITP lipoprotein analysis is useful in the differential diagnosis of hypoalphalipoproteinemia (HA). Next, we show that recombinant HDL (a complex of apolipoprotein AI mimetic peptide and phospholipids) had a significant effect on the remodeling of LDL subfractions in WHHL rabbits, an animal model of human familial hypercholesterolemia, indicating that remodeling effects on LDL subfractions is one of the mechanisms of the anti-atherogenic effects of recombinant HDL. Finally, we found that in female subjects with increased visceral fat, the subcutaneous fat area is associated with cITP sHDL, indicating that subcutaneous fat may have an effect on HDL metabolism.
All 2015 2014 2013 2012 2011
All Journal Article (15 results) (of which Peer Reviewed: 15 results, Open Access: 2 results) Presentation (3 results) Book (1 results)
J Cardiol
Volume: 65 Issue: 5 Pages: 390-396
10.1016/j.jjcc.2014.06.012
Volume: 65 Issue: 2 Pages: 05-111
10.1016/j.jjcc.2014.03.016
IJC Heart & Vessels
Volume: 2 Pages: 8-14
10.1016/j.ijchv.2013.11.002
Arterioscler Thromb Vasc Biol
Volume: 34 Issue: 10 Pages: 2246-2253
10.1161/atvbaha.114.303715
Circ J
Volume: 78 Pages: 2955-2962
Brain Dev
Volume: 36 Issue: 7 Pages: 613-619
10.1016/j.braindev.2013.08.009
J Lipid Res
Volume: 55 (5) Issue: 5 Pages: 905-18
10.1194/jlr.m047761
Epilepsy Res
Volume: 108 Issue: 3 Pages: 420-432
10.1016/j.eplepsyres.2013.12.005
Volume: 77 Pages: 2651-2663
10031196810
J Am Heart Assoc
Volume: 2 Issue: 3
10.1161/jaha.113.000048
Mol Brain
Volume: 6 Issue: 1 Pages: 19-19
10.1186/1756-6606-6-19
Volume: 76 Pages: 2241-8
10030697012
Volume: 76 Pages: 1335-44
10030315934
Clin Exp Hypertens
Volume: 34 Issue: 5 Pages: 342-9
10.3109/10641963.2012.683912
Atherosclerosis
Volume: 218 Pages: 300-307