Search for novel biomarkers associated with onset of metabolic syndrome and resistance to body weight reduction
| Project/Area Number |
23590704
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Department of Clinical Research, National Hospital Organization Kyoto Medical Center |
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Principal Investigator |
MIYANAGA Fumiko 独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究員 (80378760)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Noriko 独立行政法人国立病院機構京都医療センター, 臨床研究センター・糖尿病研究部, 研究室長(臨床代謝栄養) (80373512)
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| Co-Investigator(Renkei-kenkyūsha) |
MORISAKI Takayuki 独立行政法人国立循環器病研究センター 研究所, バイオサイエンス部, 部長 (40311451)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | メタボリック症候群 / 遺伝子多型 / バイオマーカー / 肥満 / 減量 / 糖尿病 / インスリン感受性 / メタボリックシンドローム / 遺伝子 / アディポサイトカイン |
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| Research Abstract |
The multifactorial inheritance, that plural gene variation is known in a hereditary factor, is involved in diabetes and metabolic syndrome. But there are racial differences in such a hereditary factor, so that the strongly associated gene in East Asian and Japanese is unknown so far. In this study, we identified five genes which participated in Japanese obesity and metabolic syndrome by a case-control prospective study. The genetic polymorphism of PTP1B gene was strongly associated with obesity. We clarified the effect of PTP1B genetic variations on the risk of type 2 diabetes, obesity, resistance in weight reduction and on the variability of metabolic phenotypes in Japanese population.
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Report
(4 results)
Research Products
(8 results)
