Control itch in atopic dermatitis
| Project/Area Number |
23590708
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Gunma University |
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Principal Investigator |
AMANO HIROO 群馬大学, 医学(系)研究科(研究院), 講師 (70302487)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | atopic dermatitis / itching / stress / opioid / アトピー性皮膚炎 / 痒み / ストレス / オピオイド |
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| Research Abstract |
Atopic dermatitis is a common pruritic inflammatory skin disease. It has been well recognized that environmental factors such as mites and dusts and psychological stress exacerbate atopic dermatitis. We have demonstrated that psychological stress by itself can induce scratching behaviour and trigger atopic dermatitis-like skin changes in atopic dermatitis model mice, NC/Nga. Psychological stress decreased peripheral blood and spleen NK cells, and the mRNA expression of kappa-opioid receptors in brain. On the other hand, psychological stress increased the mRNA expression of u-opioid receptors in brain. Our data suggest that the control of opioid receptor expression and NK cell profile may suppress stress-induced scratching behavior, and lead to a new treatment of atopic dermatitis.
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Report
(4 results)
Research Products
(8 results)
