Control itch in atopic dermatitis

• Project/Area Number: 23590708
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pain science
• Research Institution: Gunma University
• Principal Investigator: AMANO HIROO 群馬大学, 医学(系)研究科(研究院), 講師 (70302487)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: atopic dermatitis / itching / stress / opioid / アトピー性皮膚炎 / 痒み / ストレス / オピオイド

Research Abstract

Atopic dermatitis is a common pruritic inflammatory skin disease. It has been well recognized that environmental factors such as mites and dusts and psychological stress exacerbate atopic dermatitis. We have demonstrated that psychological stress by itself can induce scratching behaviour and trigger atopic dermatitis-like skin changes in atopic dermatitis model mice, NC/Nga. Psychological stress decreased peripheral blood and spleen NK cells, and the mRNA expression of kappa-opioid receptors in brain. On the other hand, psychological stress increased the mRNA expression of u-opioid receptors in brain. Our data suggest that the control of opioid receptor expression and NK cell profile may suppress stress-induced scratching behavior, and lead to a new treatment of atopic dermatitis.

Research Products

• [Journal Article] Microsporum canis infection mimics pemphigus erythematosus. (2013)
  • Author(s): Amano H, Kishi C, Yokoyama Y, Shimizu A, Anzawa K, Mochizuki T, Ishikawa O.
  • Journal Title: Indian Journal of Dermatology Volume: 58 Issue: 3 Pages: 243-243
  • DOI: 10.4103/0019-5154.110866
  • Peer Reviewed
• [Journal Article] Symmetric lipomatosis of the inner side of the knee: A case report and a review of the literature (2013)
  • Author(s): Amano H, Kishi C, Shimizu A, Ishikawa O.
  • Journal Title: Acta Derm Venereol Volume: 93 Issue: 6 Pages: 745-746
  • DOI: 10.2340/00015555-1585
  • Peer Reviewed
• [Journal Article] Amalgam tattoo of the oral mucosa mimics malignant melanoma. (2011)
  • Author(s): Amano H, Tamura A, Yasuda M, Yamanaka M, Takeuchi Y, Sasaoka K, Yokoo S, Ishikawa O.
  • Journal Title: Journal of Dermatology Volume: 38 Pages: 101-103
  • NAID: 10027902936
  • Peer Reviewed
• [Journal Article] Acquired reactive perforating collagenosis in dermatomyositis. (2011)
  • Author(s): Amano H, Nagai Y, Kishi C, Ishikawa O.
  • Journal Title: Journal of Dermatology Volume: 38 Pages: 1199-1201
  • NAID: 10031147174
  • Peer Reviewed
• [Presentation] Brain opioid receptor responses to psychological stress in atopic dermatitis model mice, NC/Nga (2012)
  • Author(s): Amano H, Kishi C, Yasuda M, Akiyama H, Ishikawa O
  • Organizer: 2^<nd> Eastern Asia Dermatology Congress
  • Place of Presentation: Beijing, China
• [Presentation] Brain opioid receptor responses to psychological stress in atopic dermatitis model mice. 22^<nd> World Congress of Dermatology (2011)
  • Author(s): Amano H, Kishi C, Yasuda M, Negishi I, Akiyama H, Ishikawa O
  • Organizer: The 22nd World Congress of Dermatology
  • Place of Presentation: Seoul
• [Presentation] Brain opioid receptor responses to psychological stress in atopic dermatitis model mice. (2011)
  • Author(s): Amano H, Kishi C, Yasuda M, Negishi I, Akiyama H, Ishikawa O
  • Organizer: 22nd World Congress of Dermatology
  • Place of Presentation: Seoul, Korea
• [Presentation] アトピー性皮膚炎の治療を中心に (2011)
  • Author(s): 天野博雄
  • Organizer: 第1回群信合同皮膚カンファレンス
  • Place of Presentation: 長野