Targeting acid sensing ion channels as a novel treatment for joint pain
| Project/Area Number |
23590713
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Kochi University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 関節痛 / 鎮痛薬 / 酸 / イオンチャネル / 酸感受性イオンチャネル / 国際情報交換 / 痛み / 関節 / 変形性関節症 |
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| Research Abstract |
Synovial fluid in inflamed or degenerated joint shows a drop in pH, which activates proton-gated ion channels in nociceptors. The purpose of this study was to clarify the roles of proton-gated ion channels in joint pain using selective antagonists for these ion channels in animal models. Among antagonists for ASIC1a, ASIC3, and TRPV1, only ASIC3 antagonist reduced hyperalgesia of the legs in osteoarthritis pain model and acid induced joint pain model. Furthermore, ASIC3 antagonist prevented cartilage damage in osteoarthritis model. ASIC3 antagonist is a novel and promising drug for joint pain.
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Report
(4 results)
Research Products
(15 results)
