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Targeting acid sensing ion channels as a novel treatment for joint pain

Research Project

Project/Area Number 23590713
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pain science
Research InstitutionKochi University

Principal Investigator

IKEUCHI MASAHIKO  高知大学, 教育研究部医療学系, 准教授 (00372730)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords関節痛 / 鎮痛薬 / 酸 / イオンチャネル / 酸感受性イオンチャネル / 国際情報交換 / 痛み / 関節 / 変形性関節症
Research Abstract

Synovial fluid in inflamed or degenerated joint shows a drop in pH, which activates proton-gated ion channels in nociceptors. The purpose of this study was to clarify the roles of proton-gated ion channels in joint pain using selective antagonists for these ion channels in animal models. Among antagonists for ASIC1a, ASIC3, and TRPV1, only ASIC3 antagonist reduced hyperalgesia of the legs in osteoarthritis pain model and acid induced joint pain model. Furthermore, ASIC3 antagonist prevented cartilage damage in osteoarthritis model. ASIC3 antagonist is a novel and promising drug for joint pain.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2014 2013 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (10 results) Book (1 results)

  • [Journal Article] 酸感受性イオンチャネル(ASI C)と痛み2014

    • Author(s)
      池内昌彦
    • Journal Title

      Locomotive Pain Frontier

      Volume: 3 Pages: 24-28

    • NAID

      40020251967

    • Related Report
      2013 Final Research Report
  • [Journal Article] 関節痛の発生機序2013

    • Author(s)
      池内昌彦
    • Journal Title

      ペインクリニック

      Volume: 34 Pages: 791-799

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Loc al ASIC3 modulates pain and disease pro gression in a rat model of osteoarthrit is2012

    • Author(s)
      Izumi M, Ikeuchi M, Ji Q, Tani T
    • Journal Title

      Journal of Biomedical Science

      Volume: 19 Pages: 77-77

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Local ASIC3 modulates pain and disease progression in a rat model of osteoarthritis2012

    • Author(s)
      Izumi M, Ikeuchi M, Ji Q, Tani T
    • Journal Title

      Journal of Biomedical Science

      Volume: 19 Issue: 1 Pages: 77-77

    • DOI

      10.1186/1423-0127-19-77

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 酸投与による慢性関節痛モデルにおける痛覚過敏の一機序同モデルにおける選択的酸受容体ブロッカーによる痛覚閾値変化2013

    • Author(s)
      杉村夏樹, 池内昌彦, 泉仁, 阿漕孝治, 加藤友也, 白石怜香
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      幕張メッセ,千葉
    • Related Report
      2013 Final Research Report
  • [Presentation] 変形性関節症モデルラットの疼痛行動における関節内酸性化の影響2013

    • Author(s)
      加藤友也, 池内昌彦, 杉村夏樹, 阿漕孝治, 谷俊一
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      幕張メッセ,千葉
    • Related Report
      2013 Final Research Report
  • [Presentation] Repeated intra-ar ticular injections of acid produce long -lasting hyperalgesia in rat knee2013

    • Author(s)
      Sugimura N, Ikeuchi M, Izumi M, Aso K, Zahn J, Shiraishi R
    • Organizer
      Orth opaedic Research Society annual meeting 2013
    • Place of Presentation
      Henry B Gon zalez Convention Center,San Antonio,Tex as, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Repeated intra-articular injections of acid produce long-lasting hyperalgesia in rat knee2013

    • Author(s)
      Sugimura N, IkeuchiM, Ixumi M, Aso K, Zahn J, Shiraishi R
    • Organizer
      2013 Orthopaedic Research Society annual meeting
    • Place of Presentation
      Henry B. Gonzalez Convention Center (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] ラット膝関節内への酸投与は持続性の痛覚過敏を惹起する2012

    • Author(s)
      杉村夏樹, 池内昌彦, 泉仁, 谷俊一
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋国際会議場名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of a cid sensing ion channel 3 in an experim ental model of osteoarthritis2012

    • Author(s)
      Izumi M, Ikeuchi M, Tani T
    • Organizer
      14th wor ld congress of pain
    • Place of Presentation
      Milano Convention Center, Milano,Italy
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of acid sensing ion channel 3 in an experimental model of osteoarthritis2012

    • Author(s)
      Izumi M, Ikeuchi M, Tani T
    • Organizer
      14th world congress of pain
    • Place of Presentation
      Milano Convention Centre (Italy)
    • Related Report
      2012 Research-status Report
  • [Presentation] ラット膝関節内への酸投与は持続性の痛覚過敏を惹起する2012

    • Author(s)
      杉村夏樹、池内昌彦、泉仁、谷俊一
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Related Report
      2012 Research-status Report
  • [Presentation] Analgesic effect of intra-articular ASIC3 blocker injection in a rat model of osteoarthritis2012

    • Author(s)
      Izumi M, Ikeuchi M, Ji Q, Tani T
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      Moscone West Convention Center, San Francisco, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] 変形性膝関節症モデルにおけるASIC3ブロッカー関節内投与の鎮痛効果2011

    • Author(s)
      泉仁、池内昌彦、Ji Quighui、谷俊一
    • Organizer
      日本整形外科基礎学術集会
    • Place of Presentation
      前橋商工会議所・群馬県民体育会
    • Related Report
      2011 Research-status Report
  • [Book] 痛みのScience&Practice2013

    • Author(s)
      泉仁、池内昌彦
    • Total Pages
      6
    • Publisher
      文光堂
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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