The effects of itch/scratching on allergic dermatitis.
Project/Area Number |
23590714
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pain science
|
Research Institution | Kyushu University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | アレルギー性皮膚炎 / かゆみ / 掻破行動 / アレルギー / 好中球 / 接触過敏反応 / CXCR2 / allergic skin reaction / 掻破 / マウス |
Research Abstract |
We examined association of itch/scratching and allergic dermatitis using mouse models of dermatitis. Gene transcription at 12 and 24 hours after challenge in murine contact hypersensitivity reaction using hapten and BALB/c mice were examined. We found that A total of 127 and 8 genes were differentially transcripted at 12 and 24 hours, respectively. Furthermore, the neutrophil chemoattractant MIP2-alpha was identified as initial response gene in the skin inflammation. Impaired contact hypersensitivity reaction was expected in mice lacking CXCR2, the receptor for MIP2-alpha, but interestingly, there was no change in the reaction between the knockout mice and controls. Further investigation including local immunohistology is ongoing. We could not properly assessed the scratching in another model mice lacking cathepsin E knockout mice, due to its vicious movement of the hind legs of the mice.
|
Report
(4 results)
Research Products
(50 results)
-
-
[Journal Article] Atopic dermatitis with CD30-positive anaplastic large cell lymphoma2014
Author(s)
Yasukochi Y, Takenaka K, Yurino A, Kurihara Y, Miake S, Uchi H, Takeuchi S, Kohda F, Moroi Y, Okano S, Yamamoto H, Furue M
-
Journal Title
Eur J Dermatol
Volume: 24(1)
Pages: 132-3
Related Report
-
-
-
[Journal Article] Atopic dermatitis with CD30-positive anaplastic large cell lymphoma.2014
Author(s)
3. Yasukochi Y, Takenaka K, Yurino A, Kurihara Y, Miake S, Uchi H, Takeuchi S, Kohda F, Moroi Y, Okano S, Yamamoto H, Furue M.
-
Journal Title
Eur J Dermatol.
Volume: 24
Issue: 1
Pages: 132-133
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Genetic polymorphism in the TRAF3IP2 gene is associated with psoriasis vulgaris in a Japanese population.2014
Author(s)
5. Hayashi M, Hirota T, Saeki H, Nakagawa H, Ishiuji Y, Matsuzaki H, Tsunemi Y, Kato T, Shibata S, Sugaya M, Sato S, Tada Y, Doi S, Miyatake A, Ebe K, Noguchi E, Ebihara T, Amagai M, Esaki H, Takeuchi S, Furue M, Tamari M.
-
Journal Title
J Dermatol Sci.
Volume: 73
Issue: 3
Pages: 264-265
DOI
Related Report
Peer Reviewed
-
[Journal Article] Verbalizing Extremes of the Visual Analogue Scale for Pruritus : A Consensus Statement2013
Author(s)
Furue M, Ebata T, Ikoma A, Takeuchi S, Kataoka Y, Takamori K, Satoh T, Saeki H, Augustin M, Reich A, Szepietowski J, Fleischer A, Blome C, Phan NQ, Weisshaar E, Yosipovitch G, Ständer S
-
Journal Title
Acta Derm Venereol
Volume: 93(2)
Pages: 214-215
Related Report
-
[Journal Article] Genetic polymorphisms in the IL22 gene are associated with psoriasis vulgaris in a Japanese population.2013
Author(s)
Saeki H, Hirota T, Nakagawa H, Tsunemi Y, Kato T, Shibata S, Sato S, Doi S, Miyatake A, Ebe K, Noguchi E, Ebihara T, Amagaii M, Esaki H, Takeuchi S, Furue M, Nakamura Y, Tamari M.
-
Journal Title
J Dermatol Sci.
Volume: 71
Issue: 2
Pages: 148-150
DOI
Related Report
Peer Reviewed
-
[Journal Article] Genetic polymorphisms in the IL22 gene are associated with psoriasis vulgaris in a Japanese population.2013
Author(s)
Saeki H, Hirota T, Nakagawa H, Tsunemi Y, Kato T, Shibata S, Sato S, Doi S, Miyatake A, Ebe K, Noguchi E, Ebihara T, Amagaii M, Esaki H, Takeuchi S, Furue M, Nakamura Y, Tamari M.
-
Journal Title
J Dermatol Sci
Volume: not yet
Related Report
Peer Reviewed
-
-
[Journal Article] A randomized, open-label, multicenter trial of topical tacrolimus for treatment of pruritus in patients with atopic dermatitis2012
Author(s)
Takeuchi S, Saeki H, Tokunaga S, Sugaya M, Ohmatsu H, TsunemiY, Torii H, Nakamura K, Kawakami T, Soma Y, Gyotoku E, Hide M, Sasaki R, Ohya Y, Kido M, Furue M
-
Journal Title
Ann Dermatol
Volume: 24(2)
Pages: 144-50
Related Report
-
[Journal Article] Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population2012
Author(s)
Hirota T, Takahashi A, Kubo M, Tsunoda T, Tomita K, Sakashita M, Yamada T, Fujieda S, Tanaka S, Doi S, Miyatake A, Enomoto T, Nishiyama C, Nakano N, Maeda K, Okumura K, Ogawa H, Ikeda S, Noguchi E, Sakamoto T, Hizawa N, Ebe K, Saeki H, Sasaki T, Ebihara T, Amagai M, Takeuchi S, Furue M, Nakamura Y, Tamari M
-
Journal Title
Nat Genet
Volume: 44(11)
Pages: 1222-6
Related Report
-
[Journal Article] Periostin promotes chronic allergic inflammation in response to Th2 cytokines2012
Author(s)
Masuoka M, Shiraishi H, Ohta S, Suzuki S, Arima K, Aoki S, Toda S, Inagaki N, Kurihara Y, Hayashida S, Takeuchi S, Koike K, Ono J, Noshiro H, Furue M, Conway SJ, Narisawa Y, Izuhara K
-
Journal Title
J Clin Invest
Volume: 122(7)
Pages: 2590-600
Related Report
-
-
-
[Journal Article] IL-4 and IL-12 polymorphisms are associated with response to suplatast tosilate, a Th2 cytokine inhibitor, in patients with atopic dermatitis.2012
Author(s)
Nagase H, Nakachi Y, Ishida K, Kiniwa M, Takeuchi S, Katayama I, Matsumoto Y, Fukukawa F, Morizane S, Kaneko S, Tokura Y, Takenaka M, Hatano Y and Miyachi Y.
-
Journal Title
The Open Dermatology Journal
Volume: 6
Pages: 42-50
NAID
Related Report
Peer Reviewed
-
-
[Journal Article] A randomized, open-label, multicenter trial of topical tacrolimus for treatment of pruritus in patients with atopic dermatitis.2012
Author(s)
Takeuchi S, Saeki H, Tokunaga S, Sugaya M, Ohmatsu H, TsunemiY, Torii H, Nakamura K, Kawakami T, Soma Y, Gyotoku E, Hide M, Sasaki R, Ohya Y, Kido M, Furue M.
-
Journal Title
Ann Dermatol
Volume: 24
Issue: 2
Pages: 144-150
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Periostin promotes chronic allergic inflammation in response to Th2 cytokines.2012
Author(s)
Masuoka M, Shiraishi H, Ohta S, Suzuki S, Arima K, Aoki S, Toda S, Inagaki N, Kurihara Y, Hayashida S, Takeuchi S, Koike K, Ono J, Noshiro H, Furue M, Conway SJ, Narisawa Y, Izuhara K.
-
Journal Title
J Clin Invest
Volume: 122
Issue: 7
Pages: 2590-2600
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] ORAI1 genetic polymorphisms associated with the susceptibility of atopic dermatitis in Japanese and Taiwanese populations.2012
Author(s)
Chang WC, Lee CH, Hirota T, Wang LF, Doi S, Miyatake A, Enomoto T, Tomita K, Sakashita M, Yamada T, Fujieda S, Ebe K, Saeki H, Takeuchi Sほか
-
Journal Title
Related Report
Peer Reviewed
-
-
-
[Journal Article] Variants of C-C motif chemokine 22 (CCL22) are associated with susceptibility to atopic dermatitis: case-control studies.2011
Author(s)
Hirota T, Saeki H, Tomita K, Tanaka S, Ebe K, Sakashita M, Yamada T, Fujieda S, Miyatake A, Doi S, Enomoto T, Hizawa N, Sakamoto T, Masuko H, Sasaki T他
-
Journal Title
Related Report
Peer Reviewed
-
[Journal Article] Visual Analogue Scale: Evaluation of the Instrument for the Assess-ment of Pruritus.2011
Author(s)
Reich A, Heisig M, Phan NQ, Taneda K, Takamori K, Takeuchi S, Furue M, Blome C, Augustin M, Ständer S, Szepietowski JC.
-
Journal Title
Acta Derm Venereol.
Volume: e-pub ahead of print
Issue: 5
Pages: 497-501
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Beneficial effect of a diet containing heat-killed Lactobacillus paracasei K71 on adult type atopic dermatitis.2011
Author(s)
Moroi M, Uchi S, Nakamura K, Sato S, Shimizu N, Fujii M, Kumagai T, Saito M, Uchiyama K, Watanabe T, Yamaguchi H, Yamamoto T, Takeuchi S, Furue M.
-
Journal Title
J Dermatol. 2011
Volume: 38(2)
Issue: 2
Pages: 131-139
DOI
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 皮脂欠乏性湿疹
Author(s)
竹内聡
Organizer
第17回 皮膚の日 講演会
Place of Presentation
アクロス福岡4F 国際会議場(福岡市
Related Report
Invited
-
-
-