The effects of itch/scratching on allergic dermatitis.

• Project/Area Number: 23590714
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pain science
• Research Institution: Kyushu University
• Principal Investigator: TAKEUCHI Satoshi 九州大学, 大学病院, その他 (80403997)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: アレルギー性皮膚炎 / かゆみ / 掻破行動 / アレルギー / 好中球 / 接触過敏反応 / ＣＸＣＲ２ / allergic skin reaction / 掻破 / マウス

Research Abstract

We examined association of itch/scratching and allergic dermatitis using mouse models of dermatitis. Gene transcription at 12 and 24 hours after challenge in murine contact hypersensitivity reaction using hapten and BALB/c mice were examined. We found that A total of 127 and 8 genes were differentially transcripted at 12 and 24 hours, respectively. Furthermore, the neutrophil chemoattractant MIP2-alpha was identified as initial response gene in the skin inflammation. Impaired contact hypersensitivity reaction was expected in mice lacking CXCR2, the receptor for MIP2-alpha, but interestingly, there was no change in the reaction between the knockout mice and controls. Further investigation including local immunohistology is ongoing. We could not properly assessed the scratching in another model mice lacking cathepsin E knockout mice, due to its vicious movement of the hind legs of the mice.

Research Products

• [Journal Article] Epidemiology of atopic dermatitis in Japan (2014)
  • Author(s): Takeuchi S, Esaki H, Furue M
  • Journal Title: J Dermatol Volume: 41(3) Pages: 200-4
• [Journal Article] Atopic dermatitis with CD30-positive anaplastic large cell lymphoma (2014)
  • Author(s): Yasukochi Y, Takenaka K, Yurino A, Kurihara Y, Miake S, Uchi H, Takeuchi S, Kohda F, Moroi Y, Okano S, Yamamoto H, Furue M
  • Journal Title: Eur J Dermatol Volume: 24(1) Pages: 132-3
• [Journal Article] アトピー性皮膚炎-ステロイド外用剤に抵抗性のかゆみ- (2014)
  • Author(s): 竹内聡
  • Journal Title: Dermatology Today Volume: 16 Pages: 4-9
• [Journal Article] Epidemiology of atopic dermatitis in Japan. (2014)
  • Author(s): Takeuchi S*, Esaki H, Furue M.
  • Journal Title: J Dermatol. 2014 Mar;41(3):200-4. Volume: 41 Issue: 3 Pages: 200-204
  • DOI: 10.1111/1346-8138.12331
• [Journal Article] Atopic dermatitis with CD30-positive anaplastic large cell lymphoma. (2014)
  • Author(s): 3. Yasukochi Y, Takenaka K, Yurino A, Kurihara Y, Miake S, Uchi H, Takeuchi S, Kohda F, Moroi Y, Okano S, Yamamoto H, Furue M.
  • Journal Title: Eur J Dermatol. Volume: 24 Issue: 1 Pages: 132-133
  • DOI: 10.1684/ejd.2013.2253
  • Peer Reviewed
• [Journal Article] アトピー性皮膚炎 -ステロイド外用剤に抵抗性のかゆみ- (2014)
  • Author(s): 竹内聡
  • Journal Title: Dermatology Today Volume: 16 Pages: 4-9
• [Journal Article] Genetic polymorphism in the TRAF3IP2 gene is associated with psoriasis vulgaris in a Japanese population (2014)
  • Author(s): 5. Hayashi M, Hirota T, Saeki H, Nakagawa H, Ishiuji Y, Matsuzaki H, Tsunemi Y, Kato T, Shibata S, Sugaya M, Sato S, Tada Y, Doi S, Miyatake A, Ebe K, Noguchi E, Ebihara T, Amagai M, Esaki H, Takeuchi S, Furue M, Tamari M.
  • Journal Title: J Dermatol Sci. Volume: 73 Issue: 3 Pages: 264
  • DOI: 10.1016/j.jdermsci.2013.11.012
  • Peer Reviewed
• [Journal Article] Verbalizing Extremes of the Visual Analogue Scale for Pruritus : A Consensus Statement (2013)
  • Author(s): Furue M, Ebata T, Ikoma A, Takeuchi S, Kataoka Y, Takamori K, Satoh T, Saeki H, Augustin M, Reich A, Szepietowski J, Fleischer A, Blome C, Phan NQ, Weisshaar E, Yosipovitch G, Ständer S
  • Journal Title: Acta Derm Venereol Volume: 93(2) Pages: 214-215
• [Journal Article] Genetic polymorphisms in the IL22 gene are associated with psoriasis vulgaris in a Japanese population. (2013)
  • Author(s): Saeki H, Hirota T, Nakagawa H, Tsunemi Y, Kato T, Shibata S, Sato S, Doi S, Miyatake A, Ebe K, Noguchi E, Ebihara T, Amagaii M, Esaki H, Takeuchi S, Furue M, Nakamura Y, Tamari M.
  • Journal Title: J Dermatol Sci. Volume: 71 Issue: 2 Pages: 148-150
  • DOI: 10.1016/j.jdermsci.2013.04.002
  • Peer Reviewed
• [Journal Article] Genetic polymorphisms in the IL22 gene are associated with psoriasis vulgaris in a Japanese population. (2013)
  • Author(s): Saeki H, Hirota T, Nakagawa H, Tsunemi Y, Kato T, Shibata S, Sato S, Doi S, Miyatake A, Ebe K, Noguchi E, Ebihara T, Amagaii M, Esaki H, Takeuchi S, Furue M, Nakamura Y, Tamari M.
  • Journal Title: J Dermatol Sci Volume: not yet
  • Peer Reviewed
• [Journal Article] 皮膚疾患患者・家族のためのより良いコミュニケーションのために「皮膚掻痒症」 (2012)
  • Author(s): 竹内聡
  • Journal Title: Clinical Derma Volume: 14 Pages: 9-10
• [Journal Article] A randomized, open-label, multicenter trial of topical tacrolimus for treatment of pruritus in patients with atopic dermatitis (2012)
  • Author(s): Takeuchi S, Saeki H, Tokunaga S, Sugaya M, Ohmatsu H, TsunemiY, Torii H, Nakamura K, Kawakami T, Soma Y, Gyotoku E, Hide M, Sasaki R, Ohya Y, Kido M, Furue M
  • Journal Title: Ann Dermatol Volume: 24(2) Pages: 144-50
• [Journal Article] Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population (2012)
  • Author(s): Hirota T, Takahashi A, Kubo M, Tsunoda T, Tomita K, Sakashita M, Yamada T, Fujieda S, Tanaka S, Doi S, Miyatake A, Enomoto T, Nishiyama C, Nakano N, Maeda K, Okumura K, Ogawa H, Ikeda S, Noguchi E, Sakamoto T, Hizawa N, Ebe K, Saeki H, Sasaki T, Ebihara T, Amagai M, Takeuchi S, Furue M, Nakamura Y, Tamari M
  • Journal Title: Nat Genet Volume: 44(11) Pages: 1222-6
• [Journal Article] Periostin promotes chronic allergic inflammation in response to Th2 cytokines (2012)
  • Author(s): Masuoka M, Shiraishi H, Ohta S, Suzuki S, Arima K, Aoki S, Toda S, Inagaki N, Kurihara Y, Hayashida S, Takeuchi S, Koike K, Ono J, Noshiro H, Furue M, Conway SJ, Narisawa Y, Izuhara K
  • Journal Title: J Clin Invest Volume: 122(7) Pages: 2590-600
• [Journal Article] アトピー性皮膚炎の治療アドヒアランス向上を目指した治療戦略 (2012)
  • Author(s): 竹内聡, 古江増隆
  • Journal Title: TARC症例Tool(シオノギ製薬) Pages: 1-4
• [Journal Article] Topical application of PPARα(but notβ/δorγ) suppresses atopic dermatitis in NC/Nga mice (2012)
  • Author(s): Chiba T, Takeuchi S, Esaki H, Yamamura K, Kurihara Y, Moroi Y, Furue M
  • Journal Title: Allergy Volume: 67(7) Pages: 936-42
• [Journal Article] IL-4 and IL-12 polymorphisms are associated with response to suplatast tosilate, a Th2 cytokine inhibitor, in patients with atopic dermatitis. (2012)
  • Author(s): Nagase H, Nakachi Y, Ishida K, Kiniwa M, Takeuchi S, Katayama I, Matsumoto Y, Fukukawa F, Morizane S, Kaneko S, Tokura Y, Takenaka M, Hatano Y and Miyachi Y.
  • Journal Title: The Open Dermatology Journal Volume: 6 Pages: 42-50
  • NAID: 120006986078
  • Peer Reviewed
• [Journal Article] アラスタット3g Allergyの臨床的有用性に関する検討―第2報― 多施設共同研究による評価(小児科・皮膚科における検討) (2012)
  • Author(s): 小田嶋 博、田場 直彦、藤澤 隆夫、長尾みづほ、荒川 浩一、八木 久子、秀 道広、平郡真記子、古江 増隆、竹内 聡、江崎 仁一、宮本 昭正.
  • Journal Title: Allergology & Immunology Volume: 19 Pages: 128-144
  • Peer Reviewed
• [Journal Article] A randomized, open-label, multicenter trial of topical tacrolimus for treatment of pruritus in patients with atopic dermatitis. (2012)
  • Author(s): Takeuchi S, Saeki H, Tokunaga S, Sugaya M, Ohmatsu H, TsunemiY, Torii H, Nakamura K, Kawakami T, Soma Y, Gyotoku E, Hide M, Sasaki R, Ohya Y, Kido M, Furue M.
  • Journal Title: Ann Dermatol Volume: 24 Issue: 2 Pages: 144-150
  • DOI: 10.5021/ad.2012.24.2.144
  • Peer Reviewed
• [Journal Article] Useful method to monitor the physiological effects of alcohol ingestion by combination of micro-integrated laser Doppler blood flow meter and arm-raising test. (2012)
  • Author(s): Iwasaki W, Nogami H, Ito H, Gotanda T, Peng Y, Takeuchi S, Furue M, Higurashi E, Sawada R.
  • Journal Title: Proc Inst Mech Eng H. Volume: 226 Pages: 759-65
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. (2012)
  • Author(s): Hirota T
  • Journal Title: Nat Genet Volume: 44 Issue: 11 Pages: 1222-6
  • DOI: 10.1038/ng.2438
  • Peer Reviewed
• [Journal Article] Verbalizing Extremes of the Visual Analogue Scale for Pruritus: A Consensus Statement. (2012)
  • Author(s): Furue M, Ebata T, Ikoma A, Takeuchi S, Kataoka Y, Takamori K, et al.
  • Journal Title: Acta Derm Venereol Volume: 93 Issue: 2 Pages: 214-215
  • DOI: 10.2340/00015555-1446
  • Peer Reviewed
• [Journal Article] Periostin promotes chronic allergic inflammation in response to Th2 cytokines (2012)
  • Author(s): Masuoka M, Shiraishi H, Ohta S, Suzuki S, Arima K, Aoki S, Toda S, Inagaki N, Kurihara Y, Hayashida S, Takeuchi S, Koike K, Ono J, Noshiro H, Furue M, Conway SJ, Narisawa Y, Izuhara K.
  • Journal Title: J Clin Invest Volume: 122 Issue: 7 Pages: 2590
  • DOI: 10.1172/jci58978
  • Peer Reviewed
• [Journal Article] Topical application of PPARα (but not β/δ or γ) suppresses atopic dermatitis in NC/Nga mice. (2012)
  • Author(s): Chiba T, Takeuchi S, Esaki H, Yamamura K, Kurihara Y, Moroi Y, Furue M.
  • Journal Title: Allergy Volume: 67 Issue: 7 Pages: 936-942
  • DOI: 10.1111/j.1398-9995.2012.02844.x
• [Journal Article] Correlation between serum thymus and activation-regulated chemokine levels and stratum corneum barrier function in healthy individuals and patients with mild atopic dermatitis. (2012)
  • Author(s): Furue M, Matsumoto M, Yamamoto T, Esaki H, Chiba T, Takeuchi S.
  • Journal Title: J Dermatol Sci Volume: 66 Issue: 1 Pages: 60-63
  • DOI: 10.1016/j.jdermsci.2012.01.011
• [Journal Article] Correlation between serum thymus and activation-regulated chemokine levels and stratum corneum barrier function in healthy individuals and patients with mild atopic dermatitis. (2012)
  • Author(s): Furue M, Matsumoto M, Yamamoto T, Esaki H, Chiba T, Takeuchi S.
  • Journal Title: J Dermatol Sci. Volume: 66(1) Pages: 60-63
  • Peer Reviewed
• [Journal Article] ORAI1 genetic polymorphisms associated with the susceptibility of atopic dermatitis in Japanese and Taiwanese populations. (2012)
  • Author(s): Chang WC, Lee CH, Hirota T, Wang LF, Doi S, Miyatake A, Enomoto T, Tomita K, Sakashita M, Yamada T, Fujieda S, Ebe K, Saeki H, Takeuchi Sほか
  • Journal Title: PLoS One Volume: 7(1)
  • Peer Reviewed
• [Journal Article] Identification of ketoconazole as an AhR-Nrf2 activator in cultured human keratinocytes: the basis of its anti-inflammatory effect. (2012)
  • Author(s): Tsuji G, Takahara M, Uchi H, Matsuda T, Chiba T, Takeuchi S, Yasukawa F, Moroi Y, Furue M.
  • Journal Title: J Invest Dermatol. Volume: 132(1) Issue: 1 Pages: 59-68
  • DOI: 10.1038/jid.2011.194
  • Peer Reviewed
• [Journal Article] T cell-specific overexpression of interleukin-27 receptor alpha-subunit (WSX-1) prevents spontaneous skin inflammation in MRL/lpr mice (2011)
  • Author(s): Kido M, Takeuchi S, Sugiyama N, Esaki H, Nakashima H, Yoshida H, Furue M
  • Journal Title: Br J Dermatol Volume: 164(6) Pages: 1214-20
• [Journal Article] Variants of C-C motif chemokine 22 (CCL22) are associated with susceptibility to atopic dermatitis: case-control studies. (2011)
  • Author(s): Hirota T, Saeki H, Tomita K, Tanaka S, Ebe K, Sakashita M, Yamada T, Fujieda S, Miyatake A, Doi S, Enomoto T, Hizawa N, Sakamoto T, Masuko H, Sasaki T他
  • Journal Title: PLoS One. Volume: 6(11)
  • Peer Reviewed
• [Journal Article] Visual Analogue Scale: Evaluation of the Instrument for the Assess-ment of Pruritus. (2011)
  • Author(s): Reich A, Heisig M, Phan NQ, Taneda K, Takamori K, Takeuchi S, Furue M, Blome C, Augustin M, Ständer S, Szepietowski JC.
  • Journal Title: Acta Derm Venereol. Volume: e-pub ahead of print Issue: 5 Pages: 497-501
  • DOI: 10.2340/00015555-1265
  • Peer Reviewed
• [Journal Article] Current status of atopic dermatitis in Japan. (2011)
  • Author(s): Furue M, Chiba T, Takeuchi S.
  • Journal Title: Asia Pac Allergy. Volume: 1(2) Pages: 64-72
  • Peer Reviewed
• [Journal Article] T cell-specific overexpression of interleukin-27 receptor alpha-subunit (WSX-1) prevents spontaneous skin inflammation in MRL/lpr mice (2011)
  • Author(s): Kido, M., 他
  • Journal Title: Br J Dermatol Volume: 164 Issue: 6 Pages: 1214-1220
  • DOI: 10.1111/j.1365-2133.2011.10244.x
  • Peer Reviewed
• [Journal Article] An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway. (2011)
  • Author(s): Tsuji G, Takahara M, Uchi H, Takeuchi S, Mitoma C, Moroi Y, Furue M.
  • Journal Title: J Dermatol Sci. Volume: 62(1) Pages: 42-49
  • NAID: 10030890843
  • Peer Reviewed
• [Journal Article] Beneficial effect of a diet containing heat-killed Lactobacillus paracasei K71 on adult type atopic dermatitis. (2011)
  • Author(s): Moroi M, Uchi S, Nakamura K, Sato S, Shimizu N, Fujii M, Kumagai T, Saito M, Uchiyama K, Watanabe T, Yamaguchi H, Yamamoto T, Takeuchi S, Furue M.
  • Journal Title: J Dermatol. 2011 Volume: 38(2) Issue: 2 Pages: 131-139
  • DOI: 10.1111/j.1346-8138.2010.00939.x
  • NAID: 10029330215
  • Peer Reviewed
• [Journal Article] Significant correlation of serum IL-22 levels with CCL17 levels in atopic dermatitis. (2011)
  • Author(s): Hayashida S, Uchi H, Takeuchi S, Esaki H, Moroi Y, Furue M.
  • Journal Title: J Dermatol Sci. Volume: 61(1): Pages: 78-79
  • NAID: 10030889895
  • Peer Reviewed
• [Presentation] 石垣島コホート調査（Kyushu Ishigaki Dermatitis Study; KIDS）における3gAllergyの応用 (2012)
  • Author(s): 竹内聡.
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪国際会議場グランキューブ
  • Invited
• [Presentation] アトピー性皮膚炎患者の日常生活での痒みに関するインターネット調査. (2012)
  • Author(s): 竹内聡ら。
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪国際会議場グランキューブ
• [Presentation] アトピー性皮膚炎の治療：抗炎症外用療法のポイント. (2012)
  • Author(s): 竹内聡.
  • Organizer: 第１１１回日本皮膚科学会総会
  • Place of Presentation: 国立京都国際会館
  • Invited
• [Presentation] アトピー性皮膚炎―アレルギー・日常生活の注意点と治療. (2011)
  • Author(s): 竹内聡
  • Organizer: 第48回日本小児アレルギー学会市民公開講座(招待講演)
  • Place of Presentation: 福岡サンパレスホテル２階パレスルームＡ，Ｂ
• [Presentation] ウステキヌマブ治療中の乾癬患者で上気道感染症に引き続いて発症した好酸球性肺炎であると考えられた１例. (2011)
  • Author(s): 竹内聡、小林真二、高原正和、師井洋一、古江増隆.
  • Organizer: 第26回日本乾癬学会学術大会
  • Place of Presentation: 大阪国際会議場B会場
• [Presentation] An internet web-based questionnaire survey on pruritus of patients with atopic dermatitis in daily life. (2011)
  • Author(s): Takeuchi S, Oba J, Furue M.
  • Organizer: 6th World Congress on Itch.
  • Place of Presentation: Oceanopolis (Brest, France)
• [Presentation] アトピー性皮膚炎の治療アドヒアランスについて (2011)
  • Author(s): 竹内聡
  • Organizer: 第23回日本アレルギー学会春季臨床大会(招待講演)
  • Place of Presentation: 幕張メッセ
• [Presentation] 基礎・臨床データから見た痒みのマネジメント ―タクロリムス軟膏の有用性―
  • Author(s): 竹内聡
  • Organizer: 第29回日本臨床皮膚科医会総会
  • Place of Presentation: ウェスティンナゴヤキャッスル 星雲の間西（第4会場）（名古屋市）
  • Invited
• [Presentation] アモキシシリンによる誘発疹を生じた伝染性単核球症の１例
  • Author(s): 竹内聡、三田村康貴
  • Organizer: 第65回日本皮膚科学会西部支部学術大会
  • Place of Presentation: かごしま県民交流センター B会場（大ホールA）（鹿児島市）
• [Presentation] メソトレキセートによるacute mucocutaneous toxic reactionの一例
  • Author(s): 竹内聡、三田村康貴
  • Organizer: 第43回日本皮膚 アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: ホテル日航金沢 第10会場（金沢市）
• [Presentation] 皮脂欠乏性湿疹
  • Author(s): 竹内聡
  • Organizer: 第17回 皮膚の日 講演会
  • Place of Presentation: アクロス福岡４Ｆ 国際会議場（福岡市
  • Invited
• [Presentation] アトピー性皮膚炎患者の日常生活での痒みに対するインターネットによるアンケート調査
  • Author(s): 竹内聡、大場純奈、古江増隆
  • Organizer: 第63回日本皮膚科学会西部支部学術大会
  • Place of Presentation: 沖縄コンベンションセンター 第5会場
• [Book] 臨床現場における診断時の測定・評価手法２．かゆみの測定・評価. 皮膚測定・評価手法集-使用機器の選定・評価と臨床現場での診断の実際- (2012)
  • Author(s): 竹内聡.
  • Total Pages: 174
  • Publisher: 情報機構企画部
• [Book] 竹内聡、古江増隆. １．アトピー性皮膚炎―湿疹・皮膚炎パーフェクトマスター. 皮膚科臨床アセット (2011)
  • Author(s): 古江増隆編
  • Publisher: 中山書店