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Investigation for the mechanism of neuropathic pain on spinal pain transmission.

Research Project

Project/Area Number 23590718
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pain science
Research InstitutionTohoku Pharmaceutical University

Principal Investigator

WATANABE Chizuko  東北薬科大学, 薬学部, 講師 (90296020)

Co-Investigator(Kenkyū-buntansha) SAKURADA Shinobu  東北薬科大学, 薬学部, 教授 (30075816)
MIZOGUCHI Hirokazu  東北薬科大学, 薬学部, 准教授 (30360069)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords神経障害性疼痛 / 脊髄 / 疼痛伝達物質 / 受容体 / マイクロダイアリシス
Research Abstract

Neuropathic pain is one of the serious painful syndrome in clinic. However, its mechanism is still unknown. In this project, to describe the mechanism of the neuropathic pain involvement of various neurotransmitters and its receptors on the central and peripheral nervous system was investigated in the animal model for the nerve-injured neuropathy. As the results, it was found that various neurotransmitters may play a different role for the expression and maintenance of allodynia in the neuropathic pain state.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (62 results)

All 2014 2013 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (54 results) (of which Invited: 1 results)

  • [Journal Article] Involvement of multipleμ-opioid receptor subtypes on the presynaptic or postsynaptic inhibition of spinal pain transmission2014

    • Author(s)
      Hirokazu Mizoguchi, Hirokazu Takagi, Chizuko Watanabe, Akihiko Yonezawa, Takumi Sato, Tsukasa Sakurada, Shinobu Sakurada
    • Journal Title

      Peptides

      Volume: 51 Pages: 15-25

    • DOI

      10.1016/j.peptides.2013.10.012

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential alternation of the antinociceptive effect of narcotic analgesics on the inflammatory pain state2014

    • Author(s)
      Yuta Aoki, Hirokazu Mizoguchi, Chizuko Watanabe, Tsukasa Sakurada, Shinobu Sakurada
    • Journal Title

      Neuroscience Letters

      Volume: 560 Pages: 122-125

    • DOI

      10.1016/j.neulet.2013.12.020

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential Involvement of <i>μ</i>-Opioid Receptor Dysregulation on the Reduced Antinociception of Morphine in the Inflammatory Pain State in Mice2014

    • Author(s)
      Yuta Aoki, Hirokazu Mizoguchi, Chizuko Watanabe, Kumiko Takeda, Tsukasa Sakurada,Shinobu Sakurada
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 124 Issue: 2 Pages: 258-266

    • DOI

      10.1254/jphs.13242FP

    • NAID

      130003391472

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distinct physiological role of amidino-TAPA-sensitive and DAMGO-insensitive μ-opioid receptor splice variants in the mouse spinal cord2013

    • Author(s)
      Hirokazu Mizoguchi, Chizuko Watanabe, Takayuki Higashiya, Satoshi Takeda, Kaori Moriyama, Akihiko Yonezawa, Takashi Kon-no, Hirokazu Takagi, Tsukasa Sakurada, Shinobu Sakurada
    • Journal Title

      Eur. J. Pharmacol.

      Volume: 711 Issue: 1-3 Pages: 80-86

    • DOI

      10.1016/j.ejphar.2013.04.014

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of spinal release ofα-neo-endorphin on the antinociceptive effect of TAPA2013

    • Author(s)
      Hirokazu Mizoguchi, Takashi Kon-no, Hiroyuki Watanabe, Chizuko Watanabe, Akihiko Yonezawa, Takumi Sato, Tsukasa Sakurada, Shinobu Sakurada
    • Journal Title

      Peptides

      Volume: 50 Pages: 139-144

    • DOI

      10.1016/j.peptides.2013.10.003

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] New vistas in opioid control of pain2012

    • Author(s)
      H. Mizoguchi, C. Watanabe, T. Sakurada, S. Sakurada
    • Journal Title

      Curr. Opin. Pharmacol

      Volume: 12 Issue: 1 Pages: 87-91

    • DOI

      10.1016/j.coph.2011.10.020

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The involvement of the spinal release of glutamate and nitric oxide in peripheral noxious stimulation-induced pain-related behaviors -Study in mouse spinal microdialysis-2012

    • Author(s)
      C. Watanabe, H. Mizoguchi, G. Bagetta, S. Sakurada
    • Journal Title

      Neurosci. Lett

      Volume: 515 Issue: 2 Pages: 111-114

    • DOI

      10.1016/j.neulet.2012.02.091

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Partial involvement of NMDA receptors and glial cells in the nociceptive behaviors induced by intrathecally administered histamine2011

    • Author(s)
      H. Mizoguchi, T. Komatsu, Y. Iwata, C. Watanabe, H. Watanabe, T. Orito, S. Katsuyama, A. Yonezawa, K. Onodera, T. Sakurada, S. Sakurada
    • Journal Title

      Neurosci. Lett

      Volume: 495 Issue: 2 Pages: 83-87

    • DOI

      10.1016/j.neulet.2011.02.038

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Antinociceptive effect of narcotic analgesics against mechanical allodynia in inflammatory pain state2014

    • Author(s)
      Yuta Aoki, Hirokazu Mizoguchi, Chizuko Watanabe, Akihiko Yonezawa, Shinobu Sakurada
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] The antinociceptive effect of opioid analgesics in neuropathic cancer pain2014

    • Author(s)
      Ryou Sugawara, Hirokazu Mizoguchi, Chizuko Watanabe, Akihiko Yonezawa, Syu-ichi Kanno, Masaaki Ishikawa, Hiroshi Nagase, Shinobu Sakurada
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] Antinociceptive effect of narcotic analgesics in neuropathic pain state2014

    • Author(s)
      Takahiro Sumi, Hirokazu Mizoguchi, Chizuko Watanabe, Akihiko Yonezawa, Shinobu Sakurada
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] Antipruritic effect of kappa-opioid receptor agonist in mice2014

    • Author(s)
      Takahiro Niida, Hirokazu Mizoguchi, Chizuko Watanabe, Akihiko Yonezawa, Hiroshi Nagase, Shinobu Sakurada
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] Antinociceptive effect of narcotic analgesics against mechanical allodynia in inflammatory pain state2014

    • Author(s)
      Yuta Aoki、Hirokazu Mizoguchi、Chizuko Watanabe、Akihiko Yonezawa、Shinobu Sakurada
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台市(仙台国際センター)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The antinociceptive effect of opioid analgesics in neuropathic cancer pain2014

    • Author(s)
      Ryou Sugawara、Hirokazu Mizoguchi、Chizuko Watanabe、Akihiko Yonezawa、Syu-ichi Kanno、Masaaki Ishikawa、Hiroshi Nagase、Shinobu Sakurada
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台市(仙台国際センター)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Antinociceptive effect of narcotic analgesics in neuropathic pain state2014

    • Author(s)
      Takahiro Sumi、Hirokazu Mizoguchi、Chizuko Watanabe、Akihiko Yonezawa、Shinobu Sakurada
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台市(仙台国際センター)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Phosphorylation of mu opioid receptor reduced morphine analgesia in inflammatory pain state2013

    • Author(s)
      Yuta Aoki, Hirokazu Mizoguchi, Chizuko Watanabe, Akihiko Yonezawa, Shinobu Sakurada
    • Organizer
      International Symposium for Neurosciences 2013
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] Involvement of peripheral TRPV1 receptor in neuropathic pain2013

    • Author(s)
      Yuriko Endo, Hirokazu Mizoguchi, Chizuko Watanabe, Akihiko Yonezawa, Shinobu Sakurada
    • Organizer
      International Symposium for Neurosciences 2013
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] Spinal antinociceptive effect of endomorphins in inflammatory pain and neuropathic pain2013

    • Author(s)
      Ryo Odagiri, Hirokazu Mizoguchi, Chizuko Watanabe, Akihiko Yonezawa, Shinobu Sakurada
    • Organizer
      International Symposium for Neurosciences 2013
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] Involvement of phosphorylation ofμ-opioid receptors on the bilateral reduction of morphine analgesia in inflammatory pain state2013

    • Author(s)
      Yuta Aoki, Hirokazu Mizoguchi, Chizuko Watanabe, Akihiko Yonezawa, Shinobu Sakurada
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] 多発性硬化症疼痛に対する麻薬性鎮痛薬の効果2013

    • Author(s)
      溝口広一, 渡辺千寿子, 米澤章彦, 櫻田忍
    • Organizer
      平成25年度東北薬科大学創薬研究センターシンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] μ受容体作動薬ADAMBの脊髄における抗侵害作用発現機序2013

    • Author(s)
      青木祐太, 溝口広一, 渡辺千寿子, 米澤章彦, 櫻田忍
    • Organizer
      平成25年度東北薬科大学創薬研究センターシンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] Phosphorylation of mu opioid receptor reduced morphine analgesia in inflammatory pain state2013

    • Author(s)
      Yuta Aoki, Hirokazu Mizoguchi, Chizuko Watanabe, Akihiko Yonezawa, Tsukasa Sakurada, Shinobu Sakurada
    • Organizer
      International Narcotic Research Conference
    • Place of Presentation
      Cairns (Australia)
    • Related Report
      2013 Final Research Report
  • [Presentation] Effectiveness of amidino-TAPA against morphine-resistant neuropathic pain2013

    • Author(s)
      Hirokazu Mizoguchi, Chizuko Watanabe, Akihiko Yonezawa, Tsukasa Sakurada, Shinobu Sakurada
    • Organizer
      International Narcotic Research Conference
    • Place of Presentation
      Cairns (Australia)
    • Related Report
      2013 Final Research Report
  • [Presentation] 多発性硬化症疼痛に対する麻薬性鎮痛薬の効果2013

    • Author(s)
      溝口広一, 渡辺千寿子, 米澤章彦, 長瀬博, 櫻田司, 櫻田忍
    • Organizer
      第33回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] 脊髄疼痛伝達機構に対するμ受容体サブクラスの多様的制御の解析2013

    • Author(s)
      高木宏和, 溝口広一, 渡辺千寿子, 米澤章彦, 櫻田忍
    • Organizer
      第52回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] デルモルフィン誘導体TAPAの脊髄鎮痛作用発現機構2013

    • Author(s)
      今野崇, 溝口広一, 渡辺千寿子, 米澤章彦, 櫻田忍
    • Organizer
      第52回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経絞扼性癌性疼痛における麻薬性鎮痛薬の効果2013

    • Author(s)
      菅原陵, 溝口広一, 渡辺千寿子, 米澤章彦, 菅野秀一, 石川正明, 櫻田忍
    • Organizer
      第52回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経障害性疼痛における末梢性TRPV1受容体及びNMDA受容体の関与2013

    • Author(s)
      遠藤有里子, 溝口広一, 渡辺千寿子, 米澤章彦, 櫻田忍
    • Organizer
      第52回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経障害性疼痛における各種麻薬性鎮痛薬の効果2013

    • Author(s)
      角貴祐, 溝口広一, 渡辺千寿子, 米澤章彦, 櫻田忍
    • Organizer
      第52回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] CB1受容体拮抗薬AM251はERKの活性化を介して疼痛関連行動を起こす2013

    • Author(s)
      長岡高史, 勝山壮, 溝口広一, 小松生明, 渡辺千寿子, 米澤章彦, 櫻田司, 櫻田忍
    • Organizer
      第52回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 脊髄における疼痛伝達とその制御機構の解明2013

    • Author(s)
      渡辺千寿子
    • Organizer
      第35回東北薬学セミナー
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] Phosphorylation of mu opioid receptor reduced morphine analgesia in inflammatory pain state2013

    • Author(s)
      Yuta Aoki、Hirokazu Mizoguchi、Chizuko Watanabe、Akihiko Yonezawa、Tsukasa Sakurada、Shinobu Sakurada
    • Organizer
      International Narcotic Research Conference
    • Place of Presentation
      Australia, Cairns
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effectiveness of amidino-TAPA against morphine-resistant neuropathic pain2013

    • Author(s)
      Hirokazu Mizoguchi,、Chizuko Watanabe、Akihiko Yonezawa、Tsukasa Sakurada、Shinobu Sakurada
    • Organizer
      International Narcotic Research Conference
    • Place of Presentation
      Australia, Cairns
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多発性硬化症疼痛に対する麻薬性鎮痛薬の効果2013

    • Author(s)
      溝口広一、渡辺千寿子、米澤章彦、長瀬博、櫻田司、櫻田忍
    • Organizer
      第33回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      神戸市(神戸大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Involvement of altered mu-opioid receptors in spinal cord on the reduced morphine analgesia in inflammatory pain state2012

    • Author(s)
      青木祐太, 溝口広一, 渡辺千寿子, 米澤章彦, 櫻田忍
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 化学的侵害刺激による脊髄内神経伝達物質の遊離量の変化–マウス脊髄マイクロダイアリシス法による検討–2012

    • Author(s)
      渡辺千寿子, 溝口広一, 米澤章彦, 櫻田忍
    • Organizer
      平成24年度東北薬科大学創薬センターシンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 炎症性慢性疼痛下におけるmorphineの鎮痛作用減弱機構2012

    • Author(s)
      青木祐太, 溝口広一, 渡辺千寿子, 米澤章彦, 櫻田忍
    • Organizer
      平成24年度東北薬科大学創薬センターシンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 難治性疼痛に対する脊髄endomorphinsの効果2012

    • Author(s)
      小田桐遼, 青木祐太, 溝口広一, 渡辺千寿子, 米澤章彦, 櫻田忍
    • Organizer
      第63回日本薬理学会北部会
    • Place of Presentation
      新潟
    • Related Report
      2013 Final Research Report
  • [Presentation] Involvement of altered mu-opioid receptors in spinal cord on the reduced morphine analgesia in inflammatory pain state.2012

    • Author(s)
      Yuta Aoki
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] Mechanism of reduced morphine analgesia in inflammatory pain state2011

    • Author(s)
      Yuta Aoki, Hirokazu Mizoguchi, Chizuko Watanabe, Akihiko Yonezawa, Shinobu Sakurada
    • Organizer
      Italian-Japanese International Seminar for Neurosciences
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] Different effectiveness of narcotic analgesics on multiple sclerosis-related chronic pain2011

    • Author(s)
      Asuna Otsuki, Hirokazu Mizoguchi, Chizuko Watanabe, Akihiko Yonezawa, Shinobu Sakurada
    • Organizer
      Italian-Japanese International Seminar for Neurosciences
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 炎症性慢性疼痛時におけるmorphineの鎮痛作用減弱について2011

    • Author(s)
      青木祐太, 溝口広一, 渡辺千寿子, 米澤章彦, 櫻田忍
    • Organizer
      第5回日本緩和医療薬学会年会
    • Place of Presentation
      千葉
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 多発性硬化症疼痛に対する麻薬性鎮痛薬の効果2011

    • Author(s)
      大槻明日奈, 溝口広一, 渡辺千寿子, 米澤章彦, 櫻田忍
    • Organizer
      第5回日本緩和医療薬学会年会
    • Place of Presentation
      千葉
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 炎症性慢性疼痛時におけるmorphine鎮痛作用の減弱機構2011

    • Author(s)
      青木祐太, 溝口広一, 渡辺千寿子, 米澤章彦, 櫻田忍
    • Organizer
      第62回日本薬理学会北部会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Mechanism of reduced morphine analgesia in inflammatory pain state.2011

    • Author(s)
      Yuta Aoki
    • Organizer
      Italian-Japanese International Seminar for Neurosciences
    • Place of Presentation
      Sendai
    • Related Report
      2011 Research-status Report
  • [Presentation] Different effectiveness of narcotic analgesics on multiple sclerosis-related chronic pain.2011

    • Author(s)
      Asuna Otsuki
    • Organizer
      Italian-Japanese International Seminar for Neurosciences
    • Place of Presentation
      Sendai
    • Related Report
      2011 Research-status Report
  • [Presentation] 多発性硬化症疼痛に対する麻薬性鎮痛薬の効果

    • Author(s)
      溝口広一、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      平成25年度東北薬科大学創薬研究センターシンポジウム
    • Place of Presentation
      仙台市(東北薬科大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] μ受容体作動薬ADAMBの脊髄における抗侵害作用発現機序

    • Author(s)
      青木祐太、溝口広一、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      平成25年度東北薬科大学創薬研究センターシンポジウム
    • Place of Presentation
      仙台市(東北薬科大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脊髄疼痛伝達機構に対するμ受容体サブクラスの多様的制御の解析

    • Author(s)
      高木宏和、溝口広一、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      第52回日本薬学会東北支部大会
    • Place of Presentation
      仙台市(東北大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] デルモルフィン誘導体TAPAの脊髄鎮痛作用発現機構

    • Author(s)
      今野崇、溝口広一、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      第52回日本薬学会東北支部大会
    • Place of Presentation
      仙台市(東北大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 神経絞扼性癌性疼痛における麻薬性鎮痛薬の効果

    • Author(s)
      菅原陵、溝口広一、渡辺千寿子、米澤章彦、菅野秀一、石川正明、櫻田忍
    • Organizer
      第52回日本薬学会東北支部大会
    • Place of Presentation
      仙台市(東北大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 神経障害性疼痛における末梢性TRPV1受容体及びNMDA受容体の関与

    • Author(s)
      遠藤有里子、溝口広一、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      第52回日本薬学会東北支部大会
    • Place of Presentation
      仙台市(東北大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 神経障害性疼痛における各種麻薬性鎮痛薬の効果

    • Author(s)
      角貴祐、溝口広一、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      第52回日本薬学会東北支部大会
    • Place of Presentation
      仙台市(東北大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] CB1受容体拮抗薬AM251はERKの活性化を介して疼痛関連行動を起こす

    • Author(s)
      長岡高史、勝山壮、溝口広一、小松生明、渡辺千寿子、米澤章彦、櫻田司、櫻田忍
    • Organizer
      第52回日本薬学会東北支部大会
    • Place of Presentation
      仙台市(東北大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脊髄における疼痛伝達とその制御機構の解明

    • Author(s)
      渡辺千寿子
    • Organizer
      第35回東北薬学セミナー
    • Place of Presentation
      仙台市(東北薬科大学)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 化学的侵害刺激による脊髄内神経伝達物質の遊離量の変化-マウス脊髄マイクロダイアリシス法による検討-

    • Author(s)
      渡辺 千寿子
    • Organizer
      東北薬科大学創薬センターシンポジウム
    • Place of Presentation
      仙台市
    • Related Report
      2012 Research-status Report
  • [Presentation] 炎症性慢性疼痛下におけるmorphineの鎮痛作用減弱機構

    • Author(s)
      青木 祐太
    • Organizer
      東北薬科大学創薬センターシンポジウム
    • Place of Presentation
      仙台市
    • Related Report
      2012 Research-status Report
  • [Presentation] 難治性疼痛に対する脊髄endomorphinsの効果

    • Author(s)
      小田桐 遼
    • Organizer
      第63回日本薬理学会北部会
    • Place of Presentation
      新潟市
    • Related Report
      2012 Research-status Report
  • [Presentation] Phosphorylation of mu opioid receptor reduced morphine analgesia in inflammatory pain state

    • Author(s)
      Yuta Aoki
    • Organizer
      International Symposium for Neurosciences 2013
    • Place of Presentation
      仙台市
    • Related Report
      2012 Research-status Report
  • [Presentation] Involvement of peripheral TRPV1 receptor in neuropathic pain

    • Author(s)
      Yuriko Endo
    • Organizer
      International Symposium for Neurosciences 2013
    • Place of Presentation
      仙台市
    • Related Report
      2012 Research-status Report
  • [Presentation] Spinal antinociceptive effect of endomorphins in inflammatory pain and neuropathic pain

    • Author(s)
      Ryo Odagiri
    • Organizer
      International Symposium for Neurosciences 2013
    • Place of Presentation
      仙台市
    • Related Report
      2012 Research-status Report
  • [Presentation] Involvement of phosphorylation of μ-opioid receptors on the bilateral reduction of morphine analgesia in inflammatory pain state

    • Author(s)
      Yuta Aoki
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡市
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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