Investigation for the mechanism of neuropathic pain on spinal pain transmission.
| Project/Area Number |
23590718
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKURADA Shinobu 東北薬科大学, 薬学部, 教授 (30075816)
MIZOGUCHI Hirokazu 東北薬科大学, 薬学部, 准教授 (30360069)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 神経障害性疼痛 / 脊髄 / 疼痛伝達物質 / 受容体 / マイクロダイアリシス |
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| Research Abstract |
Neuropathic pain is one of the serious painful syndrome in clinic. However, its mechanism is still unknown. In this project, to describe the mechanism of the neuropathic pain involvement of various neurotransmitters and its receptors on the central and peripheral nervous system was investigated in the animal model for the nerve-injured neuropathy. As the results, it was found that various neurotransmitters may play a different role for the expression and maintenance of allodynia in the neuropathic pain state.
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] Partial involvement of NMDA receptors and glial cells in the nociceptive behaviors induced by intrathecally administered histamine2011
Author(s)
H. Mizoguchi, T. Komatsu, Y. Iwata, C. Watanabe, H. Watanabe, T. Orito, S. Katsuyama, A. Yonezawa, K. Onodera, T. Sakurada, S. Sakurada
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Journal Title
Neurosci. Lett
Volume: 495
Issue: 2
Pages: 83-87
DOI
Related Report
Peer Reviewed
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