Medio-cortical dopamine system modifies nociceptive responses recorded in PFC

• Project/Area Number: 23590722
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pain science
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: KAWAKAMI Yoriko 東京女子医科大学, 医学部, 教授 (40075601)
• Co-Investigator(Renkei-kenkyūsha): YAGASAKI Yuki 東京女子医科大学, 医学部, 助教 (90392422)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: ACC / PFC / VTA / dipamine / amygdala / pain / dopamine / 痛み / cingulate cortex / LTD

Research Abstract

Psychological conditions exert influences on human pain sensation. The prefrontal cortex (PFC) including cingulate cortex is an area responsible for the affectional dimension of pain. The aim of the studies confirmed effects of inputs from the lmbic system to PFC on nociceptive responses. PFC receives dense monosynaptic projection from the basolateral nucleus of the amygdala (BLA). HFS delivered to the BLA induced long lasting suppression (LLS) of nociceptive responses in PFC. Antagonists of DA receptor subtypes D2 and D4 microinjected into the PFC inhibited LLS of nociceptive responses. In the next experiments, the effects of inputs from ventral tegmental area (VTA) to PFC were examined. HFS delivered to VTA induced LLS of nociceptive responses. DA D2R activation mediated by local D2 agonist injection also induced LLS. The BLA-PFC pathways and mesocortical DA system may modify PFC nociceptive responses via D2 activity.

Research Products

• [Journal Article] Mesocortical dopamine system modulates mechanical nociceptive responses recorded in the rat prefrontal cortex (2013)
  • Author(s): Sogabe Shoichi, Yagasaki Yuki, Onozawa Kitaro, Kawakami Yoriko
  • Journal Title: BMC Neurosience Volume: 4
  • NAID: 120007163713
  • Peer Reviewed
• [Journal Article] Mesocortical dopamine system modulates mechanical nociceptive responses recorded in the rat prefrontal cortex (2013)
  • Author(s): Shoichi Sogabe, Yuki Yagasaki, Kitaro Onozawa and Yoriko Kawakami
  • Journal Title: BMC Neuroscience Volume: 2013, 14:65 Pages: 1-11
  • NAID: 120007163713
  • Peer Reviewed
• [Journal Article] Reduction of pain behavior by stimulation of the basolateral amygdalar nuclei freely moving rats (2012)
  • Author(s): Onozawa Kitaro, Abe Hiroyuki, Kawakami Yoriko
  • Journal Title: Neurophysiology Volume: 44 (5) Pages: 394-400
  • Peer Reviewed
• [Journal Article] 大脳基底核障害では中枢感覚系が直接障害されるか (2012)
  • Author(s): Yoriko Kawakami, Yoshikazu Ugawa, Astushi Nambu
  • Journal Title: Frontiers in Parkinson Disease Volume: 5 (2) Pages: 5-11
• [Journal Article] Reduction of Pain Behavior by Stimulation of the Basolateral Amygdalar Nuclei Freely Moving Rats. (2012)
  • Author(s): Kitaro Onozawa, Yumi Izawa, Hiroyuki Abe, & Yoriko Kawakami
  • Journal Title: Neurophysiology Volume: 44 Pages: 394-400
  • Peer Reviewed
• [Journal Article] Amygdala-prefrontal pathways and the dopamine system affect nociceptive responses in the prefrontal cortex (2011)
  • Author(s): Onozawa Kitaro, Yagasaki Yuki, Abe Hiroyuki, Kawakami Yoriko
  • Journal Title: BMC Neuroscience Volume: 15 (12) Pages: 115-125
  • NAID: 120007163714
  • Peer Reviewed
• [Journal Article] ドパミンシステムによる痛みの修飾飾 (2011)
  • Author(s): 曽我部昌一,川上順子
  • Journal Title: Frontiers in Parkinson Disease Volume: 4(1) Pages: 18-22
• [Journal Article] Amygdala-prefrontal pathways and the dopamine system affect nociceptive responses in the prefrontal cortex (2011)
  • Author(s): Kitaro Onozawa1†, Yuki Yagasaki2†, Yumi Izawa2†, Hiroyuki Abe1† and Yoriko Kawakami2
  • Journal Title: BMC Neuroscience Volume: 12 Pages: 115-125
  • NAID: 120007163714
  • Peer Reviewed
• [Journal Article] ドパミンシステムによる痛みの修飾 (2011)
  • Author(s): 曽我部昌一、川上順子
  • Journal Title: Frontiers in Parkinson Disease Volume: 4 Pages: 18-22
• [Remarks]
  • URL: http://gyoseki.twmu.ac.jp/twmhp/KgApp
• [Remarks] 東京女子医科大学情報公開
  • URL: http://gyoseki.twmu.ac.jp/twmhp/KgApp?kozac=C10300000000&year=2013