Medio-cortical dopamine system modifies nociceptive responses recorded in PFC
| Project/Area Number |
23590722
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pain science
|
|---|
| Research Institution | Tokyo Women's Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YAGASAKI Yuki 東京女子医科大学, 医学部, 助教 (90392422)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
|---|
| Keywords | ACC / PFC / VTA / dipamine / amygdala / pain / dopamine / 痛み / cingulate cortex / LTD |
|---|
| Research Abstract |
Psychological conditions exert influences on human pain sensation. The prefrontal cortex (PFC) including cingulate cortex is an area responsible for the affectional dimension of pain. The aim of the studies confirmed effects of inputs from the lmbic system to PFC on nociceptive responses. PFC receives dense monosynaptic projection from the basolateral nucleus of the amygdala (BLA). HFS delivered to the BLA induced long lasting suppression (LLS) of nociceptive responses in PFC. Antagonists of DA receptor subtypes D2 and D4 microinjected into the PFC inhibited LLS of nociceptive responses. In the next experiments, the effects of inputs from ventral tegmental area (VTA) to PFC were examined. HFS delivered to VTA induced LLS of nociceptive responses. DA D2R activation mediated by local D2 agonist injection also induced LLS. The BLA-PFC pathways and mesocortical DA system may modify PFC nociceptive responses via D2 activity.
|
Report
(4 results)
Research Products
(11 results)
