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Medio-cortical dopamine system modifies nociceptive responses recorded in PFC

Research Project

Project/Area Number 23590722
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pain science
Research InstitutionTokyo Women's Medical University

Principal Investigator

KAWAKAMI Yoriko  東京女子医科大学, 医学部, 教授 (40075601)

Co-Investigator(Renkei-kenkyūsha) YAGASAKI Yuki  東京女子医科大学, 医学部, 助教 (90392422)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
KeywordsACC / PFC / VTA / dipamine / amygdala / pain / dopamine / 痛み / cingulate cortex / LTD
Research Abstract

Psychological conditions exert influences on human pain sensation. The prefrontal cortex (PFC) including cingulate cortex is an area responsible for the affectional dimension of pain. The aim of the studies confirmed effects of inputs from the lmbic system to PFC on nociceptive responses. PFC receives dense monosynaptic projection from the basolateral nucleus of the amygdala (BLA). HFS delivered to the BLA induced long lasting suppression (LLS) of nociceptive responses in PFC. Antagonists of DA receptor subtypes D2 and D4 microinjected into the PFC inhibited LLS of nociceptive responses. In the next experiments, the effects of inputs from ventral tegmental area (VTA) to PFC were examined. HFS delivered to VTA induced LLS of nociceptive responses. DA D2R activation mediated by local D2 agonist injection also induced LLS. The BLA-PFC pathways and mesocortical DA system may modify PFC nociceptive responses via D2 activity.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (11 results)

All 2013 2012 2011 Other

All Journal Article (9 results) (of which Peer Reviewed: 6 results) Remarks (2 results)

  • [Journal Article] Mesocortical dopamine system modulates mechanical nociceptive responses recorded in the rat prefrontal cortex2013

    • Author(s)
      Sogabe Shoichi, Yagasaki Yuki, Onozawa Kitaro, Kawakami Yoriko
    • Journal Title

      BMC Neurosience

      Volume: 4

    • NAID

      120007163713

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mesocortical dopamine system modulates mechanical nociceptive responses recorded in the rat prefrontal cortex2013

    • Author(s)
      Shoichi Sogabe, Yuki Yagasaki, Kitaro Onozawa and Yoriko Kawakami
    • Journal Title

      BMC Neuroscience

      Volume: 2013, 14:65 Pages: 1-11

    • NAID

      120007163713

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of pain behavior by stimulation of the basolateral amygdalar nuclei freely moving rats2012

    • Author(s)
      Onozawa Kitaro, Abe Hiroyuki, Kawakami Yoriko
    • Journal Title

      Neurophysiology

      Volume: 44 (5) Pages: 394-400

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 大脳基底核障害では中枢感覚系が直接障害されるか2012

    • Author(s)
      Yoriko Kawakami, Yoshikazu Ugawa, Astushi Nambu
    • Journal Title

      Frontiers in Parkinson Disease

      Volume: 5 (2) Pages: 5-11

    • Related Report
      2013 Final Research Report
  • [Journal Article] Reduction of Pain Behavior by Stimulation of the Basolateral Amygdalar Nuclei Freely Moving Rats.2012

    • Author(s)
      Kitaro Onozawa, Yumi Izawa, Hiroyuki Abe, & Yoriko Kawakami
    • Journal Title

      Neurophysiology

      Volume: 44 Pages: 394-400

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Amygdala-prefrontal pathways and the dopamine system affect nociceptive responses in the prefrontal cortex2011

    • Author(s)
      Onozawa Kitaro, Yagasaki Yuki, Abe Hiroyuki, Kawakami Yoriko
    • Journal Title

      BMC Neuroscience

      Volume: 15 (12) Pages: 115-125

    • NAID

      120007163714

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ドパミンシステムによる痛みの修飾飾2011

    • Author(s)
      曽我部昌一,川上順子
    • Journal Title

      Frontiers in Parkinson Disease

      Volume: 4(1) Pages: 18-22

    • Related Report
      2013 Final Research Report
  • [Journal Article] Amygdala-prefrontal pathways and the dopamine system affect nociceptive responses in the prefrontal cortex2011

    • Author(s)
      Kitaro Onozawa1†, Yuki Yagasaki2†, Yumi Izawa2†, Hiroyuki Abe1† and Yoriko Kawakami2
    • Journal Title

      BMC Neuroscience

      Volume: 12 Pages: 115-125

    • NAID

      120007163714

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] ドパミンシステムによる痛みの修飾2011

    • Author(s)
      曽我部昌一、川上順子
    • Journal Title

      Frontiers in Parkinson Disease

      Volume: 4 Pages: 18-22

    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://gyoseki.twmu.ac.jp/twmhp/KgApp

    • Related Report
      2013 Final Research Report
  • [Remarks] 東京女子医科大学情報公開

    • URL

      http://gyoseki.twmu.ac.jp/twmhp/KgApp?kozac=C10300000000&year=2013

    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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