Effect of radiofrequency hyperthermia on pain thresholds in osteoarthritis
| Project/Area Number |
23590723
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小澤 一史 日本医科大学, 医学部, 教授 (60169290)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 変形性関節症 / 温熱療法 / 動物モデル / ラジオ波 / 国際情報交換 / 米国 / 温熱慮法 |
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| Research Abstract |
The purpose of this study was to clarify the mechanism underlying the therapeutic effects of radiofrequency hyperthermia in naturally occurring OA of Hartley guinea pigs by investigating the level of autophagy. Thermotron-RF300, which can apply a 13.56 MHz radio frequency pulse to the animal knees was used to perform hyperthermia. The quantitative analysis of the distribution of positive cells showed that, in the normal cartilage, ULK1 and Beclin1 were highly expressed. Seven days after the exposure to the radiofrequency, the expression levels of ULK1 and Beclin1 were augmented in animals with moderate OA. The severity of cartilage degradation was significantly reduced in the radiofrequency-treated knees compared with the untreated left knees. These results suggest that radiofrequency hyperthermia can stimulate autophagy, which is reduced in OA cartilage. In addition, radiofrequency reduced the severity of spontaneous osteoarthritis.
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Report
(4 results)
Research Products
(7 results)
