| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Repeated cold stress (RCS) is known to transiently induce autonomic imbalance associated with hypotension and hyperalgesia. This hyperalgesia is thought to be caused by hypofunction of pain inhibitory systems. In this study, we detected changes in pain-related genes expression in the dorsal root ganglion cells (DRGs) by means of two methods, PCR-based cDNA subtraction analysis and DNA microarray analysis in SHRSP5/Dmcr rats. We found significant increase or decrease expressions in eight pain related genes at post-RCS. At least some of these genes in DRG may play key roles to hyperalgesia induced by RCS.
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