Global gene expression analysis of mechanical hyperalgesia induced by repeated cold stress in rats
| Project/Area Number |
23590724
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Kinjo Gakuin University |
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Principal Investigator |
KOZAKI Yasuko 金城学院大学, 薬学部, 准教授 (20126882)
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| Co-Investigator(Kenkyū-buntansha) |
KITAMORI Kazuya 金城学院大学, 生泺環境学部, 准教授 (80387597)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 繰り返し低温ストレス / 痛覚過敏 / 遺伝子発現 / 末梢性疼痛機序 / 繰り返し寒冷ストレス / 末梢性機序 / 痛み関連遺伝子 / 動脈脂肪沈着易発症ラット / 末梢性感作機序 / 高脂肪・高コレステロール食 / サブスタンスP |
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| Research Abstract |
Repeated cold stress (RCS) is known to transiently induce autonomic imbalance associated with hypotension and hyperalgesia. This hyperalgesia is thought to be caused by hypofunction of pain inhibitory systems. In this study, we detected changes in pain-related genes expression in the dorsal root ganglion cells (DRGs) by means of two methods, PCR-based cDNA subtraction analysis and DNA microarray analysis in SHRSP5/Dmcr rats. We found significant increase or decrease expressions in eight pain related genes at post-RCS. At least some of these genes in DRG may play key roles to hyperalgesia induced by RCS.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Cutaneous mechanical hyperalgesia induced by a high-fat-cholesterol diet in SHRSP5/Dmcr rats: upregulation of Mss4 in dorsal root ganglion cells（Abst.）2013
Author(s)
Yasuko Kozaki, Yuka Hasegawa, Yukako Mizukami, Rena Umetsu, Chinami Ishikawa, Yukie Nakagawa, Yuri Morikawa, Haruhi Yasue, Aya Yamamura, and Kazuya Kitamori
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Journal Title
J. Physiol. Sci.,
Volume: vol. 63, (Suppl.1)
Related Report
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