Development of long-lasting effect of an implanted analgesic hydrogel to control the postoperative pain

• Project/Area Number: 23590728
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pain science
• Research Institution: Kansai Medical University
• Principal Investigator: KAIBORI Masaki 関西医科大学, 医学部, 准教授 (30333199)
• Co-Investigator(Kenkyū-buntansha): ITO Seiji 関西医科大学, 医学部, 教授 (80201325)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 手術後創部痛 / 埋め込み式持続鎮痛ゲル / 術後鎮痛 / 鎮痛剤 / 除法効果 / 患側坐骨神経ブロックモデル

Research Abstract

Implantation of ketoprofen-infiltrated gelatin hydrogel exerted a sustained analgesic effect for 1 week after the operation. Preemptive analgesia with zaltoprofen, another NSAID, produced an additive analgesic effect in conjunction with the ketoprofen-infiltrated hydrogel. Microglial activation was attenuated by the treatment with ketoprofen-infiltrated hydrogel on day 3 after the incision.These results demonstrate that ketoprofen was effective in reducing mechanical hypersensitivity for 1 week in a rat model of postoperative pain and that the implantation of NSAID-infiltrated gelatin hydrogel may serve as a useful analgesic method for the long-term relief of patients after surgery.

Research Products

• [Journal Article] Computer-aided liver surgical planning system using CT volumes (2013)
  • Author(s): Chen YW, Kaibori M, Shindo T, Miyawaki K, Foruzan AH, Tateyama T, Han XH, Matsui K, Tsuda T, Kwon AH
  • Journal Title: Conf Proc IEEE Eng Med Biol Soc Pages: 2360-3
  • Peer Reviewed
• [Journal Article] A prospective randomized controlled trial of hemostasis with a bipolar sealer during hepatic transection for liver resection (2013)
  • Author(s): Kaibori M, Matsui K, Ishizaki M, Sakaguchi T, Matsushima H, Matsui Y, Kwon AH
  • Journal Title: Surgery Volume: 154(5) Pages: 1046-52
  • Peer Reviewed
• [Journal Article] Assessment of preoperative exercise capacity in hepatocellular carcinoma patients with chronic liver injury undergoing hepatectomy (2013)
  • Author(s): Kaibori M, Ishizaki M, Matsui K, Nakatake R, Sakaguchi T, Habu D, Yoshiuchi S, Kimura Y, Kon AH
  • Journal Title: BMC Gastroenterol Volume: 22;13(1)(Epub ahead of print) Pages: 119-119
  • Peer Reviewed
• [Journal Article] Novel liver visualization and surgical simulation system (2013)
  • Author(s): Kaibori M, Chen YW, Matsui K, Ishizaki M, Tsuda T, Nakatake R, Sakaguchi T, Matsushima H, Miyawaki K, Shindo T, Tateyama T, Kwon AH
  • Journal Title: J Gastrointest Surg Volume: 17(8) Pages: 1422-8
  • Peer Reviewed
• [Journal Article] Interleukin-1βinduces tumor necrosis factor-αsecretion from rat hepatocytes (2013)
  • Author(s): Yoshigai E, Hara T, Inaba H, Hashimoto I, Tanaka Y, Kaibori M, Kimura T, Okumura T, Kwon AH, Nishizawa M
  • Journal Title: Hepatol Res Volume: [Epub ahead of print] Issue: 5 Pages: 571-583
  • DOI: 10.1111/hepr.12157
  • Peer Reviewed
• [Journal Article] Nutritional status and quality of life in current patients with liver cirrhosis as assessed in 2007-2011 (2013)
  • Author(s): Shiraki M, Nishiguchi S, Saito M, Fukuzawa Y, Mizuta T, Kaibori M, Hanai T, Nishimura K, Shimizu M, Tsurumi H, Moriwaki H
  • Journal Title: Hepatol Res Volume: 43(2) Pages: 106-12
  • NAID: 10031194529
  • Peer Reviewed
• [Journal Article] Perioperative exercise for chronic liver injury patients with hepatocellular carcinoma undergoing hepatectomy (2013)
  • Author(s): Kaibori M, Ishizaki M, Matsui K, Nakatake R, Yoshiuchi S, Kimura Y, Kwon AH
  • Journal Title: Am J Surg Volume: 206(2) Pages: 202-9
  • Peer Reviewed
• [Journal Article] Natural antisense transcript-targeted regulation of inducible nitric oxide synthase mRNA levels (2013)
  • Author(s): Yoshigai E, Hara T, Araki Y, Tanaka Y, Oishi M, Tokuhara K, Kaibori M, Okumura T, Kwon AH, Nishizawa M
  • Journal Title: Nitric Oxide Volume: 1;30 Pages: 9-16
  • Peer Reviewed
• [Journal Article] Clinicopathological features of recurrence in patients after 10-year disease-free survival following curative hepatic resection of hepatocellular carcinoma (2013)
  • Author(s): Kaibori M, Kubo S, Nagano H, Hayashi M, Haji S, Nakai T, Ishizaki M, Matsui K, Uenishi T, Takemura S, Wada H, Marubashi S, Komeda K, Hirokawa F, Nakata Y, Uchiyama K, Kwon AH
  • Journal Title: World J Surg Volume: 37(4) Pages: 820-8
  • NAID: 40019794845
  • Peer Reviewed
• [Journal Article] Fluvastatin inhibits the induction of inducible nitric oxide synthase, an inflammatory biomarker, in hepatocytes (2013)
  • Author(s): Tokuhara K, Habara K, Oishi M, Miki H, Tanaka Y, Kaibori M, Nishizawa M, Okumura T, Kwon AH
  • Journal Title: Hepatol Res Volume: 43(7) Pages: 775-84
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• [Journal Article] 肝実質切離における凝固機器のランダム化比較試験 (2013)
  • Author(s): 海堀昌樹, 松井康輔, 石崎守彦, 坂口達馬, 松島英之, 菱川秀彦, 中竹利知, 津田匠, 松井陽一, 權雅憲
  • Journal Title: Jounal of Microwave Surgery Volume: 31 Pages: 21-25
  • NAID: 130003369253
• [Journal Article] 肝シュミレーション技術の現状と展望 (2013)
  • Author(s): 松井康輔, 海堀昌樹, 石崎守彦, 權雅憲
  • Journal Title: 外科 Volume: 75(11) Pages: 1172-1177
• [Journal Article] 肝癌術後の運動・栄養療法を組み合わせた包括的リハビリテーション (2013)
  • Author(s): 海堀昌樹
  • Journal Title: 臨床栄養 Volume: 123(5) Pages: 649-651
• [Journal Article] 【高齢者の栄養管理】高齢者周術期の栄養管理 (2013)
  • Author(s): 海堀昌樹, 松井康輔, 石崎守彦, 坂口達馬, 松島英之, 菱川秀彦, 中竹利知, 吉内佐和子, 大北沙由利, 權雅憲
  • Journal Title: 栄養-評価と治療 Volume: 30(3) Pages: 214-218
• [Journal Article] 肝障害と誘導型一酸化窒素合成酵素-ラット初代培養肝細胞を用いた肝保護試薬のスクリーニング- (2013)
  • Author(s): 海堀昌樹, 松井康輔, 徳原克治, 荒木吉朗, 奥村忠芳, 西澤幹雄, 權雅憲
  • Journal Title: 最新医学 Volume: 68(8)
  • NAID: 40019781264
• [Journal Article] 肝細胞癌術後長期無再発生存のための術前および術後血小板数維持の意義 (2013)
  • Author(s): 海堀昌樹, 松井康輔, 石崎守彦, 權雅憲, 上西崇弘, 竹村茂一, 久保正二, 和田浩志, 丸橋繁, 永野浩昭, 米田浩二, 廣川文鋭, 林道廣, 内山和久, 中田靖幸, 土師誠二, 中居卓也
  • Journal Title: 消化器内科 Volume: 57(2) Pages: 196-202
• [Journal Article] 患者に特化した肝臓情報とその脈管分布可視化および対話かつ直感的な手術支援システムの構築 (2013)
  • Author(s): 健山智子, 海堀昌樹, 進藤典, Foruzan Amir Hossein, 林正倫, 宮脇康介, 津田匠, 松井康輔, 權雅憲, 韓先花, 姜彗研, 陳延偉
  • Journal Title: MEDICAL IMAGING TECHNOLOGY Volume: 31(3) Pages: 176-187
  • NAID: 130003374511
• [Journal Article] 胆道結石症および肝膿瘍治療後に確認された肝内胆管癌の1例 (2013)
  • Author(s): 坂口達馬, 海堀昌樹, 松井康輔, 石崎守彦, 松島英之, 松井陽一, 權雅憲, 宮坂知佳, 植村芳子.
  • Journal Title: 消化器外科 Volume: 36(6) Pages: 1001-1006
• [Journal Article] 高齢者肝細胞癌肝切除術に対する外科治療成績 (2013)
  • Author(s): 海堀昌樹, 松井康輔, 石崎守彦, 坂口達馬, 松島英之, 菱川秀彦, 中竹利知, 津田匠, 福井淳一, 松井陽一, 權雅憲
  • Journal Title: 日本外科系連合学会誌 Volume: 38(2) Pages: 224-231
  • NAID: 10031176104
• [Journal Article] 障害肝合併肝細胞癌患者の周術期BCAA顆粒製剤投与を含めた運動・栄養療法の臨床効果 (2013)
  • Author(s): 海堀昌樹, 錦戸公為, 松井康輔, 石崎守彦, 中竹利知, 坂口達馬, 松島英之, 吉内佐和子, 宮内拓史, 斉田茜, 大北沙由利, 木村穣, 羽生大記, 權雅憲
  • Journal Title: 消化と吸収 Volume: 35(2) Pages: 210-217
  • NAID: 10031169265
• [Journal Article] Meeting Report第20回日本消化器関連学会週間(JDDW2012) (2013)
  • Author(s): 海堀昌樹
  • Journal Title: The Liver Cancer Journal Volume: 5(1) Pages: 50-53
  • NAID: 40019668663
• [Journal Article] 医工学部連携における肝切除シュミレーションモデルの開発 (2013)
  • Author(s): 海堀昌樹, 陳延偉, 津田匠, 坂口達馬, 石崎守彦, 中竹利知, 松島英之, 宮脇康介, 進藤典, 松井康輔, 健山智子, 權雅憲
  • Journal Title: 胆と膵 Volume: 34(1) Pages: 19-25
• [Journal Article] 肝疾患その他の肝腫瘍 (2013)
  • Author(s): 海堀昌樹, 權雅憲
  • Journal Title: 消化器外科学レビュー Pages: 92-100
• [Journal Article] Novel Strategy for the Control of Postoperative Pain:Long-Lasting Effect of an Implanted Analgesic Hydrogel (2012)
  • Author(s): Yoshiro Araki, MD, PhD,* Masaki Kaibori, MD, PhD,* Shinji Matsumura, PhD
  • Journal Title: Anesth Analg Volume: 114 Pages: 1338-1345
  • Peer Reviewed
• [Presentation] A Novel Perioperative Care Protocol for Hepatectomy Patients (2013)
  • Author(s): Kaibori M, Matsui K, Ishizaki M, Sakaguchi T, Hishikawa H, Matsushima H, Miyata G, Kwon AH
  • Organizer: KOREA SOCIETY for SURGICAL METABOLISM and NUTRITION, Symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2013-03-16
• [Presentation] 関西肝臓外科医育成の会の取り組み (2013)
  • Author(s): 久保正二, 永野浩昭, 海堀昌樹, 林道廣, 中居卓也, 寺嶋宏明, 塚本忠司, 高済峯, 相原司, 木戸正浩, 寺駒久視, 上野昌樹, 野見武男
  • Organizer: 第75回日本臨床外科学会総会特別企画
  • Place of Presentation: 名古屋
• [Presentation] 当科での高齢者肝細胞癌切除成績よりみた外科治療指針再考の提案 (2013)
  • Author(s): 海堀昌樹, 松井康輔, 石崎守彦, 坂口達馬, 松島英之, 松井陽一, 權雅憲
  • Organizer: 第75回日本臨床外科学会総会シンポジウム
  • Place of Presentation: 名古屋
• [Presentation] 当科での術後ペインフリーへの挑戦～消化器外科領域における術後痛の評価～ (2013)
  • Author(s): 海堀昌樹, 松井康輔, 石崎守彦, 坂口達馬, 荒木吉朗, 大北沙由里, 權雅憲
  • Organizer: 第33回日本臨床麻酔学会学術集会シンポジウム
  • Place of Presentation: 石川
• [Presentation] 当科での進行肝細胞癌に対するソラフェニブを中心とした集学的治療 (2013)
  • Author(s): 海堀昌樹, 石崎守彦, 松井康輔, 坂口達馬, 松島英之, 中竹利知, 權雅憲
  • Organizer: 第51回日本癌治療学会学術集会臓器別シンポジウム
  • Place of Presentation: 京都
• [Presentation] 肝細胞癌におけるmTORシグナル伝達機構と外科術後再発抑止のための治療戦略 (2013)
  • Author(s): 海堀昌樹, 坂口達馬, 權雅憲
  • Organizer: 第55回日本消化器関連学会(JDDW)シンポジウム
  • Place of Presentation: 東京
• [Presentation] ペインフリーへの挑戦～消化器外科領域における術後疼痛の評価～ (2013)
  • Author(s): 海堀昌樹
  • Organizer: 第44回日本看護学会-成人看護I学術集会特別講演(ランチョンセミナー)
  • Place of Presentation: 和歌山
• [Presentation] Clinicopathological Characteristics of Patients with non-B non-C Hepatitis Virus Hepatocellular Carcinoma after Hepatectomy (2012)
  • Author(s): Kaibori M, Ishizaki M, Matsui K, Kwon AH
  • Organizer: KOREA SOCIETY for SURGICAL METABOLISM and NUTRITION, Symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2012-03-05
• [Presentation] 術後早期回復プログラムによる肝癌肝切除周術期栄養・運動療法の実践 (2012)
  • Author(s): 海堀昌樹, 木村穣, 權雅憲
  • Organizer: 第39回日本肝臓学会東部会特別企画
  • Place of Presentation: 東京
• [Presentation] ペインフリーへの挑戦!～消化器外科領域における術後痛の評価～ (2012)
  • Author(s): 海堀昌樹
  • Organizer: 第25回日本内視鏡外科学会総会特別講演(ランチョンセミナー)
  • Place of Presentation: 横浜
• [Presentation] Clinicopathological characteristics of patients with non-B non-C hepatitis virus hepatocellular carcinoma after hepatectomy (2011)
  • Author(s): Kaibori M,Matsui K,Ishizaki M, Kwon AH
  • Organizer: IASGO 21st World Congress of the International Association of Surgeons, Gastroenterologists,and Oncologists, Symposium
  • Place of Presentation: Tokyo, Japan
• [Presentation] 大阪府内5大学合同による肝臓外科医育成の会の取り組み (2011)
  • Author(s): 久保正二, 永野浩昭, 林道廣, 海堀昌樹, 土師誠二
  • Organizer: 第66回日本消化器外科学会総会特別企画
  • Place of Presentation: 名古屋
• [Presentation] 肝癌肝切除周術期の包括的リハビリテーションの臨床効果 (2011)
  • Author(s): 海堀昌樹
  • Organizer: 第66回日本消化器外科学会総会特別講演(ランチョンセミナー)
  • Place of Presentation: 名古屋
• [Book] ESSENSE (2014)
  • Author(s): 海堀昌樹、谷口英喜
  • Total Pages: 169
  • Publisher: 春恒社
• [Book] 肝疾患に対する運動処方および運動療法の実際.肝疾患運動療法ハンドブック (2013)
  • Author(s): 木村穣, 海堀昌樹
  • Publisher: メディカルレビュー社
• [Book] 肝癌手術患者に対する運動療法の効果.肝疾患運動療法ハンドブック (2013)
  • Author(s): 海堀昌樹, 松井康輔, 石崎守彦, 權雅憲,宮内拓史,木村穣
  • Publisher: メディカルレビュー社
• [Patent(Industrial Property Rights)] 局所麻酔薬持続徐放性リポソーム製剤(上記の分割出願) (2013)
  • Inventor(s): 海堀昌樹, 權雅憲, 伊藤誠二, 荒木吉朗, 山下恵子, 黒崎靖夫, 春本誠, 島村京子
  • Industrial Property Rights Holder: 関西医科大学, テルモ株式会社
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-076408
  • Filing Date: 2013-04-01
  • Overseas
• [Patent(Industrial Property Rights)] 局所麻酔薬持続徐放性リポソーム製剤 (2013)
  • Inventor(s): 權雅憲、
  • Industrial Property Rights Holder: 權雅憲、
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-04-01
• [Patent(Industrial Property Rights)] 局所麻酔薬持続徐放性リポソーム製剤 (2012)
  • Inventor(s): 海堀昌樹, 權雅憲, 伊藤誠二, 荒木吉朗, 山下恵子, 黒崎靖夫, 春本誠, 島村京子
  • Industrial Property Rights Holder: 関西医科大学, テルモ株式会社
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-208890
  • Filing Date: 2012-09-21
  • Overseas