| Project/Area Number |
23590732
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HARA Koji 産業医科大学, 医学部, 講師 (20331001)
TERADA Tadanori 産業医科大学, 医学部, 助教 (10399206)
NAKAMURA Motohiro 産業医科大学, 医学部, 助教 (30461578)
SATA Takeyoshi 産業医科大学, 医学部, 教授 (60128030)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 行動薬理学 / 鎮痛薬 / 神経障害性疼痛 / 脳室内投与 / Kチャネル開口薬 / 髄腔内投与 |
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| Research Abstract |
The analgesic effects of ATP sensitive potassium channel openers were examined using a rat neuropathic pain model. Chronic constriction injury to the sciatic nerve was induced in male Sprague–Dawley rats. Structurally distinct drugs, diazoxide, pinacidil, and nicorandil were administered intrathecally or intracerebroventricularly to examine the central effects on mechanical, thermal, and cold hyperalgesia. These drugs applied spinally and supraspinally attenuated mechanical and cold hyperalgesia in a dose-dependent manner, but they had no effect on thermal hyperalgesia. The ATP sensitive potassium channel openers may exert antihyperalgesic effects both in the spinal cord and brain.
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