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Behavioral study on analgesic effect of ATP sensitive potassium channel openers

Research Project

Project/Area Number 23590732
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pain science
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

HARANISHI Yasunori  産業医科大学, 医学部, 講師 (90449942)

Co-Investigator(Kenkyū-buntansha) HARA Koji  産業医科大学, 医学部, 講師 (20331001)
TERADA Tadanori  産業医科大学, 医学部, 助教 (10399206)
NAKAMURA Motohiro  産業医科大学, 医学部, 助教 (30461578)
SATA Takeyoshi  産業医科大学, 医学部, 教授 (60128030)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords行動薬理学 / 鎮痛薬 / 神経障害性疼痛 / 脳室内投与 / Kチャネル開口薬 / 髄腔内投与
Research Abstract

The analgesic effects of ATP sensitive potassium channel openers were examined using a rat neuropathic pain model. Chronic constriction injury to the sciatic nerve was induced in male Sprague–Dawley rats. Structurally distinct drugs, diazoxide, pinacidil, and nicorandil were administered intrathecally or intracerebroventricularly to examine the central effects on mechanical, thermal, and cold hyperalgesia. These drugs applied spinally and supraspinally attenuated mechanical and cold hyperalgesia in a dose-dependent manner, but they had no effect on thermal hyperalgesia. The ATP sensitive potassium channel openers may exert antihyperalgesic effects both in the spinal cord and brain.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (3 results)

All 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results)

  • [Journal Article] Chlorogenic acid administered intrathecally alleviates mechanical and cold hyperalgesia in a rat neuropathic pain model.2014

    • Author(s)
      Hara K, Haranishi Y, Kataoka K, Takahashi Y, Terada T, Nakamura M, Sata T.
    • Journal Title

      European Journal of Pharmacology

      Volume: 723 Pages: 459-464

    • DOI

      10.1016/j.ejphar.2013.10.046

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Antinociceptive Effect of SNAP5114, a Gamma-Aminobutyric Acid Transporter-3 Inhibitor, in Rat Experimental Pain Models.2013

    • Author(s)
      Kataoka K, Hara K, Haranishi Y, Terada T, Sata T
    • Journal Title

      Anesth Analg

      Volume: 116 Issue: 5 Pages: 1162-9

    • DOI

      10.1213/ane.0b013e318282dda7

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain2012

    • Author(s)
      Hara K., Nakamura M., Haranishi Y., Terada T., Kataoka K., Sata T
    • Journal Title

      Amino Acids

      Volume: (In press) Issue: 1 Pages: 397-404

    • DOI

      10.1007/s00726-011-1094-9

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed

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Published: 2011-08-05   Modified: 2019-07-29  

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