Pathogenesis of chemical sensitivity as seen from the respiratory secretions response to TRPV-1 activity
| Project/Area Number |
23590733
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Tohoku University |
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Principal Investigator |
IROKAWA Toshiya 東北大学, 環境・安全推進センター, 准教授 (70375179)
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| Co-Investigator(Kenkyū-buntansha) |
KUROSAWA Hajime 東北大学, 環境・安全推進センター, 教授 (60333788)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 産業中毒 / 化学物質過敏症の生体防御機構 / TRPV-1 / 化学物質過敏症 / 生体防御反応 / 気道分泌 / 気道粘膜下腺 / 気道粘膜防御機構 |
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| Research Abstract |
For the purpose of elucidate the pathogenesis of "chemical sensitivity", we have examined it by the relationship to the respiratory secretions that is innate biological defense reaction of the respiratory tract. We have focused on respiratory secretions through the noxious stimuli-sensitive receptor TRPV-1(transient receptor potential, vanilloid subfamily member 1), which is estimated to be exposed-stimulation sensitive site in the respiratory tract and used optical methods to measure the airway secretion for investigating the defense mechanism of MCS patients.Our consequence would be explained that the addition of capsaicin (10uM), which is the agonist of TRPV1, to the mucosal side mild increased airway secretion and it is elevated temporarily in the airway mucosa that is exposed formalin (20ppm) for 30-60min.
These data suggest the possibility of airway secretion is elevated temporarily in MCS patients.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Measurement of fluid secretion from intact airway submucosal glands2011
Author(s)
Wine JJ, Joo NS, Choi JY, Cho HJ, Krouse ME, Wu JV, Khansaheb M, Irokawa T, Ianowski J, Hanrahan JW, Cuthbert AW, Tran KV
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Journal Title
Methods Mol Biol
Volume: 742
Pages: 93-112
DOI
ISBN
9781617791192, 9781617791208
Related Report
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[Journal Article] Measurement of fluid secretion from intact airway submucosal glands.2011
Author(s)
Wine JJ, Joo NS, Choi JY, Cho HJ, Krouse ME, Wu JV, Khansaheb M, Irokawa T, Ianowski J, Hanrahan JW, Cuthbert AW, Tran KV.
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Journal Title
Methods Mol Biol.
Volume: 742
Pages: 93-112
Related Report
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[Presentation] 東日本大震災被災地がれき処理場の継続的な土壌細菌叢解析からみた被災地復旧作業労働者の健康障害要因の評価2013
Author(s)
色川俊也, 諸冨伸夫, 福田和正, 馬田敏幸, 進藤拓, 中村修, 矢内勝, 広瀬俊雄, 小川浩正, 谷口初美, 黒澤一
Organizer
第86回日本産業衛生学会
Place of Presentation
松山市
Year and Date
2013-05-16
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