Source and exposure of emerging persistent organic pollutants

• Project/Area Number: 23590739
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene
• Research Institution: Kyoto University
• Principal Investigator: HARADA Kouji 京都大学, 医学(系)研究科(研究院), 准教授 (80452340)
• Co-Investigator(Renkei-kenkyūsha): KOIZUMI Akio 京都大学, 大学院医学研究科, 教授 (50124574)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 残留性有機汚染物質 / 化学分析 / モニタリング / 汚染源 / 越境汚染 / 環境化学 / ヒト試料 / 生物モニタリング

Research Abstract

POPs candidates, short-chain chlorinated paraffins, organofluorine compounds, are detected at low concentrations by using a chemical ionization mass spectrometry.
The measurements were performed for samples that has been collected in Kyoto University biological specimen bank. Dietary intake, geographic distribution in Japan, and the source of exposure were evaluated. There was no change over the past decade in intake of organofluorine compounds in Japan. Serum levels showed the similar composition ratio of the homologues and correlation between seafood intake. Levels in breast milk samples revealed the exposure of the infant. For short-chain chlorinated paraffins, it is detected in the food duplicate samples, especially in China. In the breast milk samples, chlorinated tridecane was observed in China, and some chlorinated undecane in Japan.

Research Products

• [Journal Article] Methylmercury Monitoring Study in Karakuwacho, a Peninsula Area in Japan (2014)
  • Author(s): Junxia Yan, Kayoko Inoue, Akihiro Asakawa, Kouji H. Harada, Takao Watanabe, Noriyuki Hachiya, Akio Koizumi
  • Journal Title: Bull. Environ. Contam. Toxicol Volume: 93 Issue: 1 Pages: 36-41
  • DOI: 10.1007/s00128-014-1241-6
  • Peer Reviewed
• [Journal Article] Radiation dose rates now and in the future for residents neighboring restricted areas of the Fukushima Daiichi Nuclear Power Plant. (2014)
  • Author(s): Harada, K. H. ; Niisoe, T. ; Iman aka, M. ; Takahashi, T. ; Amako, K. ; Fuiii, Y. ; Kanameishi, M. ; Ohse, K. ; Nakai, Y. ; Nishikawa, T . ; Saito, Y. ; Sakamoto, H. ; Ueya ma, K. ; Hisaki, K. ; Ohara, E. ; I noue, T. ; Yamamoto, K. ; Matsuoka, Y ; Ohata, H. ; Toshima, K. ; Okada, A. ; Sato, H. ; Kuwamori, T. ; Tani, H. ; Suzuki, R. ; Kashikura, M. ; Nezu, M. ; Miyachi, Y. ; Arai, F. ; Kuwamori, M. ; Harada, S. ; Ohmori, A. ; Ishikawa, H. ; Koizumi, A.
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 111(10) Issue: 10
  • DOI: 10.1073/pnas.1315684111
  • Peer Reviewed
• [Journal Article] Temporal trend and age-dependent serum concentration of phenolic organohalogen contaminants in Japanese men during 1989-2010. (2014)
  • Author(s): Fuiii, Y. ; Harada, K. H. ; Hitomi, T. ; Kobayashi, H. ; Koizumi, A. ; Haraguchi, K
  • Journal Title: Environ Pollut Volume: 185 Pages: 228-233
  • DOI: 10.1016/j.envpol.2013.11.002
  • Peer Reviewed
• [Journal Article] Dietary exposure to phenolic and methoxylated organohalogen contamin ants in relation to their concentrations in breast milk and serum in Ja pan. (2014)
  • Author(s): Fuiii, Y. ; Nishimura, E. ; Kato, Y . ; Harada, K. H. ; Koizumi, A. ; Haraguchi, K.
  • Journal Title: Environ Int Volume: 63 Pages: 19-25
  • DOI: 10.1016/j.envint.2013.10.016
  • Peer Reviewed
• [Journal Article] Temporal trend and age-dependent serum concentration of phenolic organohalogen contaminants in Japanese men during 1989-2010. (2014)
  • Author(s): Fujii Y, Harada KH, Hitomi T, Kobayashi H, Koizumi A, Haraguchi K
  • Journal Title: Environ Pollut Volume: 185 Pages: 228-33
  • Peer Reviewed
• [Journal Article] Dietary exposure to phenolic and methoxylated organohalogen contaminants in relation to their concentrations in breast milk and serum in Japan (2014)
  • Author(s): Fujii Y, Nishimura E, Kato Y, Harada KH, Koizumi A, Haraguchi K.
  • Journal Title: Environ Int Volume: 63 Pages: 19-25
  • Peer Reviewed
• [Journal Article] Methylmercury Monitoring Study in Karakuwacho Peninsula Area in Japan (2014)
  • Author(s): Yan J, Inoue K, Asakawa A, Harada KH, Watanabe T, Hachiya N, Koizumi A
  • Journal Title: Bull Environ Contam Toxicol Volume: 電子版 Pages: 1-6
  • Peer Reviewed
• [Journal Article] Levels of urinary isoflavones and lignan polyphenols in Japanese women. (2013)
  • Author(s): Liu W, Tanabe M, Harada KH, Koizumi A
  • Journal Title: Environ Health Prev. Med Volume: 18(5) Issue: 5 Pages: 394-400
  • DOI: 10.1007/s12199-013-0338-6
  • NAID: 10031201233
  • Peer Reviewed
• [Journal Article] Occurrence of perfluorinated carboxylic acids (PFCAs) in personal care products and compounding agents (2013)
  • Author(s): Fujii Y, Harada KH, Koizumi A
  • Journal Title: Chemosphere Volume: 93(3) Issue: 3 Pages: 538-544
  • DOI: 10.1016/j.chemosphere.2013.06.049
  • Peer Reviewed
• [Journal Article] Dietary Intake of Radiocesium in Adult Residents in Fukushima Prefecture and Neighboring Regions after the Fukushima Nuclear Power Plant Accident : 24 hr-Food Duplicate Survey in December 2011 (2013)
  • Author(s): Harada KH. Fujii Y, Adachi A, Tsukidate A, Asai F, Koizumi A
  • Journal Title: Environ Sci Technol. Volume: 47(6) Issue: 6 Pages: 2520-2526
  • DOI: 10.1021/es304128t
  • Peer Reviewed
• [Journal Article] Polyfluorinated telomers in indoor air of Japanese houses (2013)
  • Author(s): Liu W, Takahashi S, Sakuramachi Y, Harada KH, Koizumi A
  • Journal Title: Chemosphere Volume: 90 (5) Issue: 5 Pages: 1672-1677
  • DOI: 10.1016/j.chemosphere.2012.09.062
  • Peer Reviewed
• [Journal Article] Analysis of perfluoroalkyl carboxylic acids in composite dietary samples by gas chromatography/mass spectrometry with electron capture negative ionization (2013)
  • Author(s): Fujii Y, Harada KH, Koizumi A.
  • Journal Title: Environ Sci Technol. Volume: 46(20) Issue: 20 Pages: 11235-11242
  • DOI: 10.1021/es302536g
  • Peer Reviewed
• [Journal Article] Comparative survey of levels of chlorinated cyclodiene pesticides in breast milk from some cities of China, Korea and Japan (2013)
  • Author(s): Fujii Y, Ito Y, Harada KH, Hitomi T, Koizumi A, Haraguchi
  • Journal Title: Cheiosphere Volume: 89(4) Issue: 4 Pages: 452-457
  • DOI: 10.1016/j.chemosphere.2012.05.098
  • Peer Reviewed
• [Journal Article] Levels and profiles of long-chain perfluorinated carboxylic acids in human breast milk and infant formulas in East Asia (2012)
  • Author(s): Fujii Y, Yan J, Harada KH, Hitomi T, Yang H, Wang P, Koizumi A
  • Journal Title: Chemosphere Volume: 86(3) Issue: 3 Pages: 315-321
  • DOI: 10.1016/j.chemosphere.2011.10.035
  • NAID: 120003779162
  • Peer Reviewed
• [Journal Article] Regional variation and possible sources of brominated contaminants in breast milk from Japan (2012)
  • Author(s): Fujii Y, Ito Y, Harada KH, Hitomi T, Koizumi A, Haraguchi K
  • Journal Title: Environ. Poll Volume: 162 Pages: 269-274
  • DOI: 10.1016/j.envpol.2011.11.022
  • Peer Reviewed
• [Journal Article] Preliminary assessment of ecological exposure of adult residents in Fukushima Prefecture to radioactive cesium through ingestion and inhalation (2011)
  • Author(s): Koizumi A, et al
  • Journal Title: Environ Health Prev Med Volume: (Epub ahead of print) Issue: 4 Pages: 292-298
  • DOI: 10.1007/s12199-011-0251-9
  • Peer Reviewed
• [Journal Article] Analysis of perfluoroalkyl carboxylates in vacuum cleaner dust samples in Japan (2011)
  • Author(s): Liu W, Chen S, Harada KH, Koizumi A
  • Journal Title: Chemosphere Volume: 85(11) Issue: 11 Pages: 1734-1741
  • DOI: 10.1016/j.chemosphere.2011.09.024
  • Peer Reviewed
• [Journal Article] Dietary exposure to short-chain chlorinated paraffins has increased in Beijine, China (2011)
  • Author(s): Harada, K.
  • Journal Title: Enviromental.Science and Technology Volume: 45(16) Issue: 16 Pages: 7019-7027
  • DOI: 10.1021/es200576d
  • Peer Reviewed
• [Journal Article] Odd-numbered perfluorocarboxylates predominate over perfluorooctanoic acid in serum samples from Japan, Korea and Vietnam (2011)
  • Author(s): Harada KH, Hitomi T, Niisoe T, Takenaka K, Kamiyama S, Watanabe T, Moon CS, Yang HR, Hung NN, Koizumi A
  • Journal Title: Environ. Int Volume: 37(7) Issue: 7 Pages: 1183-1189
  • DOI: 10.1016/j.envint.2011.04.011
  • Peer Reviewed
• [Presentation] ヒト血清中ペルフルオロアルキルカルボン酸とn-3系不飽和脂肪酸との関連 (2014)
  • Author(s): 原田浩二, 藤井由希子, 趙山, 大島匡世, 大澤めぐみ, 厳俊霞, 藤原登司一, 新添多聞, 小林果, 人見敏明, 小泉昭夫
  • Organizer: 第23回日本環境化学会討論会
  • Place of Presentation: 京都大学
• [Presentation] 短鎖塩素化パラフィンの日本・韓国・中国の食品・母乳における調査結果 (2013)
  • Author(s): 苗田千尋, 原田浩二, 高菅卓三, 小泉昭夫
  • Organizer: 第22回日本環境化学会討論会
  • Place of Presentation: 東京農工大学
• [Presentation] 食事中ペルフルオロアルキルカルボン酸(PFCAs)のGC/ECNI/MS高感度分析 (2013)
  • Author(s): 藤井由希子, 原田浩二, 小泉昭夫
  • Organizer: 第83回日本衛生学会総会
  • Place of Presentation: 金沢大学
• [Presentation] 化粧品・日焼け止とその原料化成品中のペルフルオロアルキルカルボン酸(PFCAs)の検出 (2013)
  • Author(s): 藤井由希子, 原田浩二, 小泉昭夫
  • Organizer: 第83回日本衛生学会総会
  • Place of Presentation: 金沢大学
• [Presentation] 短鎖塩素化パラフィンのトピックと環境化学的問題点（日本・韓国・中国における調査結果） (2013)
  • Author(s): 高菅卓三、苗田千尋、原田浩二、小泉昭夫
  • Organizer: 第22回 日本環境化学会討論会
  • Place of Presentation: 東京農工大学
• [Presentation] 短鎖塩素化パラフィンの日本・韓国・中国の食品・母乳における調査結果 (2013)
  • Author(s): 苗田千尋、原田浩二、高菅卓三、小泉昭夫
  • Organizer: 第22回 日本環境化学会討論会
  • Place of Presentation: 東京農工大学
• [Presentation] 福島県相双地方3地域における陰膳法を用いた放射性セシウム摂取量調査 (2013)
  • Author(s): 原田浩二、今中美栄、桑守豊美、尼子克己、藤井由希子、要石真利、新添多聞、小泉昭夫
  • Organizer: 第83回 日本衛生学会総会
  • Place of Presentation: 金沢大学
• [Presentation] GC-ECNI-MSによる食事試料中ペルフルオロカルボン酸の分析 (2012)
  • Author(s): 原田浩二, 藤井由希子, 小泉昭夫
  • Organizer: 第21回日本環境化学会討論会
  • Place of Presentation: 愛媛県県民文化会館
• [Presentation] 炭素鎖の異なる有機フッ素カルボン酸における体内動態の相違 (2012)
  • Author(s): 藤井由希子, 原田浩二, 新添多聞, 小泉昭夫
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都大学
• [Presentation] GC-ECNI-MSによる食事試料中ペルフルオロカルボン酸の分析 (2012)
  • Author(s): 原田浩二、藤井由希子、小泉昭夫
  • Organizer: 第21回 日本環境化学会討論会
  • Place of Presentation: 愛媛県県民文化会館
• [Presentation] 日中韓の食事試料中の短鎖塩素化パラフィンとその汚染源の探索 (2011)
  • Author(s): 原田浩二, 高菅卓三, 人見敏明, 王培玉, 小泉昭夫
  • Organizer: 第51回近畿産業衛生学会
  • Place of Presentation: 奈良県立文化会館
  • Year and Date: 2011-11-05
• [Presentation] 有機フッ化カルボン酸化合物(C7～C12)の体内動態 (2011)
  • Author(s): 小泉昭夫, 藤井由希子, 原田浩二
  • Organizer: 第51回近畿産業衛生学会
  • Place of Presentation: 奈良県立文化会館
  • Year and Date: 2011-11-05
• [Presentation] 炭素鎖の異なる有機フッ素カルボン酸における体内動態の相違 (2011)
  • Author(s): 藤井由希子, 原田浩二, 小泉昭夫
  • Organizer: 第51回近畿産業衛生学会
  • Place of Presentation: 奈良県立文化会館
  • Year and Date: 2011-11-05
• [Presentation] クリーナーダスト中ペルフルオロアルキルカルボン酸(PFCAs)の分析 (2011)
  • Author(s): 原田浩二, 劉万洋, 陳聖英, 小泉昭夫
  • Organizer: 第20回日本環境化学会討論会
  • Place of Presentation: 熊本県立大学
• [Presentation] 母乳中ペルフルオロアルキルカルボン酸の分析法の検討 (2011)
  • Author(s): 藤井由希子, 原田浩二, 小泉昭夫
  • Organizer: 第20回日本環境化学会討論会
  • Place of Presentation: 熊本県立大学
• [Presentation] 日中韓の食事試料中の短鎖塩素化パラフィンとその汚染源の探索 (2011)
  • Author(s): 原田浩二、高菅卓三、人見敏明、王培玉、小泉昭夫
  • Organizer: 第51回 近畿産業衛生学会
  • Place of Presentation: 奈良県立文化会館
• [Book] Comparing pesticides in human breast milk from China, Korea and Japan, Handbook of dietary and nutritional aspects of human breast milk : Prevention (2013)
  • Author(s): Akio Koizumi, Kouji Harada, Yukiko Fujii (edited by: Sherma Zibadi, Ronald RossWatson and Victor R. Preedy)
  • Publisher: Wageningen Academic Publishers(ISBN 978-90-8686-209-2)
• [Book] Handbook of dietary and nutritional aspects of human breast milk: Prevention, treatment and toxicity (2013)
  • Author(s): Sherma Zibadi, Ronald Ross Watson and Victor R. Preedy
  • Total Pages: 852
  • Publisher: Wageningen Academic Publishers
• [Remarks]
  • URL: http://hes.med.kyoto-u.ac.jp/