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Effects of exercise training on inflammaging: the role of macrophages in the molecular mechanisms

Research Project

Project/Area Number 23590752
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hygiene
Research InstitutionKyorin University

Principal Investigator

KIZAKI Takako  杏林大学, 医学部, 教授 (00322446)

Co-Investigator(Renkei-kenkyūsha) OHNO Hideki  杏林大学, 医学部, 教授 (00133819)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Keywordsマクロファージ / 炎症反応 / 老化 / 運動トレーニング / グレリン / 時計遺伝子 / 慢性炎症
Research Abstract

Exercise training prevented the infiltration of inflammatory macrophages to adipose tissue and exerted anti-inflammatory effects for obesity-related chronic inflammation. Expression of ghrelin, which exerts potent anti-inflammatory effects, in peritoneal marophages was decreased by obesity and recovered by exercise training, suggesting that exercise training suppresses obesity-induced inflammation through ghrelin. On the other hand, a circadian clock gene Rev-erb modulates the inflammatory function of macrophages through the direct regulation of a chemokine Ccl2 expression. Overexpression of Rev-erb in murine macrophage cell line RAW264 cells suppressed the induction of Ccl2 following a LPS endotoxin challenge, resulting in impaired the activity of cell adhesion and migration. These data suggest that Rev-erb regulates the inflammatory infiltration of macrophages through the suppression of Ccl2 expression and participates in aging- or obesity-associated inflammation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (97 results)

All 2014 2013 2012 2011 Other

All Journal Article (39 results) (of which Peer Reviewed: 38 results,  Open Access: 1 results) Presentation (43 results) (of which Invited: 2 results) Book (15 results)

  • [Journal Article] A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression.2014

    • Author(s)
      Sato S, Sakurai T, Ogasawara J, Takahashi M, Izawa T, Imaizumi K, Taniguchi N, Ohno H, Kizaki T.
    • Journal Title

      J Immunol.

      Volume: 192 Issue: 1 Pages: 407-417

    • DOI

      10.4049/jimmunol.1301982

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ETAS, an enzyme-treated asparagus extract, attenuates amyloidβ-induced cellular disorder in PC12 cells2014

    • Author(s)
      Ogasawara, J., Ito, T., Wakame, K., Kitadate, K., Sakurai, T., Sato, S., Ishibashi, Y., Izawa, T., Takahashi, K., Ishida, H., Takabatake, I., Kizaki, T. and Ohno, H
    • Journal Title

      Nat. Prod. Commun

      Volume: 9 Pages: 561-564

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enzyme-treated Asparagus officinalis extract shows neuroprotective effects and attenuates cognitive impairment in senescence- accelerated mice2014

    • Author(s)
      Sakurai, T., Ito, T., Wakame, K., Kitadate, K., Arai, T., Ogasawara, J., Kizaki, T., Sato, S., Ishibashi, Y., Fujiwara, T., Akagawa, K., Ishida, H. and Ohno, H
    • Journal Title

      Nat. Prod. Commun

      Volume: 9 Pages: 101-106

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enzyme-treated asparagus officinalis extract shows neuroprotective effects and attenuates cognitive impairment in senescence-accelerated mice.2014

    • Author(s)
      Sakurai, T., et al.
    • Journal Title

      Nat. Prod. Commun.

      Volume: 9 Pages: 101-106

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ETAS, an enzyme-treated asparagus extract, attenuates amyloid β-induced cellular disorder in PC12 cells.2014

    • Author(s)
      Ogasawara, J., et al.
    • Journal Title

      Nat. Prod Commun.

      Volume: 9 Pages: 561-564

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular β2-adrenergic receptor signaling specificity in mouse skeletal muscle in response to single-dose β2-agonist clenbuterol treatment and acute exercise2013

    • Author(s)
      Sato, S., Shirato, K., Mitsuhashi, R., Inoue, D., Kizaki, T., Ohno, H., Tachiyashiki, K. & Imaizumi, K
    • Journal Title

      J. Physiol. Sci

      Volume: 63 Issue: 3 Pages: 211-218

    • DOI

      10.1007/s12576-013-0253-z

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oligomerised lychee fruit-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells.2013

    • Author(s)
      Sakurai T, Kitadate K, Nishioka H, Fujii H, Ogasawara J, Kizaki T, Sato S, Fujiwara T, Akagawa K, Izawa T, Ohno H.
    • Journal Title

      Br J Nutr.

      Volume: 110 Issue: 9 Pages: 1549-1558

    • DOI

      10.1017/s000711451300086x

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effects of exercise training on obesity-induced dysregulated expression of adipokines in white adipose tissue.2013

    • Author(s)
      Sakurai T, Ogasawara J, Kizaki T, Sato S, Ishibashi Y, Takahashi M, Kobayashi O, Oh-Ishi S, Nagasawa J, Takahashi K, Ishida H, Izawa T, Ohno H.
    • Journal Title

      Int J Endocrinol.

      Volume: Article ID801743 Pages: 1-28

    • DOI

      10.1155/2013/801743

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exercise and oxidative stress in hypoxia2013

    • Author(s)
      Nagasawa, J., Kizaki, T. and Ohno, H
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 2 Issue: 4 Pages: 481-486

    • DOI

      10.7600/jpfsm.2.481

    • NAID

      10031203888

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exercise and oxidative stress in hypoxia.2013

    • Author(s)
      Nagasawa, J., et al.
    • Journal Title

      J. Phys. Fit. Sports Med.

      Volume: 2 Pages: 481-486

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Skeletal Muscle Oxygenation during Nagewaza Karari Exercise in Judo.2013

    • Author(s)
      Haga, S., et al.
    • Journal Title

      Sport Sci. Res.

      Volume: 10 Pages: 233-241

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effets of long-term exercise on cerebral functiobn and the maintenance of concentration in the elderly.2013

    • Author(s)
      Haga, S., et al
    • Journal Title

      J. Exerc. Sports Orthop.

      Volume: 1 Pages: 6-11

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of resistance exercise on intramuscular oxygenation and muscle fiber composition.2013

    • Author(s)
      Aita, F., et al.
    • Journal Title

      J. Sports Med. Doping Stud.

      Volume: 3 Issue: 03 Pages: 3-9

    • DOI

      10.4172/2161-0673.1000133

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Copy number variations due to large genomic deletion in X-linked chronic granulomatous disease2012

    • Author(s)
      Arai, T., et al
    • Journal Title

      PLoS One

      Volume: 7 Issue: 2 Pages: e27782-e27782

    • DOI

      10.1371/journal.pone.0027782

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of exercise on HIF-1 and VEGF signaling2012

    • Author(s)
      Ohno, H., Shirato, K., Sakurai, T., Ogasawara, J., Sumitani, Y., Sato, S., Imaizumi, K., Ishida, H. and Kizaki, T
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 1 Issue: 1 Pages: 5-16

    • DOI

      10.7600/jpfsm.1.5

    • NAID

      10031158921

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of exercise on macrophage function2012

    • Author(s)
      Kizaki, T., Sato, S., Sakurai, T., Ogasawara, J., Imaizumi, K., Izawa, T., Nagasawa, J., Saitoh, D., Haga, S. and Ohno, H
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 1 Issue: 1 Pages: 113-123

    • DOI

      10.7600/jpfsm.1.113

    • NAID

      10031158932

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of β<sub>2</sub>-agonists and exercise on β<sub>2</sub>-adrenergic receptor signaling in skeletal muscles2012

    • Author(s)
      Sato, S., Shirato, K., Kizaki, T., Ohno, H., Tachiyashiki, K. and Imaizumi, K
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 1 Issue: 1 Pages: 139-144

    • DOI

      10.7600/jpfsm.1.139

    • NAID

      10031158935

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of exercise on the hexosamine biosynthetic pathway and glycosylation2012

    • Author(s)
      Shirato, K., Kizaki, T., Ohno, H. and Imaizumi, K
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 1 Issue: 1 Pages: 145-150

    • DOI

      10.7600/jpfsm.1.145

    • NAID

      10031158936

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Higher levels of ATGL are associated with exercise-induced enhancement of lipolysis in rat epididymal adipocytes.2012

    • Author(s)
      小笠原準悦
    • Journal Title

      PLoS ONE

      Volume: 7(7) Issue: 7 Pages: e40876-e40876

    • DOI

      10.1371/journal.pone.0040876

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oligonol-induced Degradation of Perilipin 1 is Regulated through Lysosomal Degradation Machinery2012

    • Author(s)
      Ogasawara, J., Kitadate, K., Nishioka, H., Fujii, H., Sakurai, T., Kizaki, T., Izawa, T., Ishida, H. and Ohno, H
    • Journal Title

      Nat. Prod. Commun

      Volume: 7 Pages: 1193-1196

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of physical exercise on lipolysis in white adipocytes2012

    • Author(s)
      Ogasawara Junetsu
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 1 Issue: 2 Pages: 351-356

    • DOI

      10.7600/jpfsm.1.351

    • NAID

      10031158965

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exercise training and the promotion of neurogenesis and neurite outgrowth in the hippocampus2012

    • Author(s)
      Sakurai, T., Ogasawara, J., Kizaki, T., Ishibashi, Y., Fujiwara, T., Akagawa, K., Izawa, T., Radák, Z. and Ohno, H
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 1 Issue: 2 Pages: 333-337

    • DOI

      10.7600/jpfsm.1.333

    • NAID

      10031158961

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recent advances in the adaptations of adipose tissue to physical activity: Morphology and adipose tissue cellularity2012

    • Author(s)
      井澤鉄也
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 1 Issue: 3 Pages: 381-387

    • DOI

      10.7600/jpfsm.1.381

    • NAID

      10031158969

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oligonol-induced Degradation of Perilipin 1 is Regulated through Lysosomal Degradation Machinery.2012

    • Author(s)
      Ogasawara, J., et al.
    • Journal Title

      Nat. Prod. Commun.

      Volume: 7 Pages: 1193-1196

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preventive and improvement effects of exercise training and supplement intake in white adipose tissues on obesity and lifestyle-related diseases2012

    • Author(s)
      Sakurai, T., Ogasawara, J., Kizaki, Takahashi, K., Ishida, H., Miyazaki, H., Saitoh, D., Haga, S., Izawa, T. & Ohno, H.
    • Journal Title

      Environ. Health Prev. Med

      Volume: 17(in press) Issue: 5 Pages: 348-356

    • DOI

      10.1007/s12199-012-0271-0

    • NAID

      10031120507

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of exercise on HIF-1 and VEGF signaling2012

    • Author(s)
      Ohno, H. et al.
    • Journal Title

      J. Phys. Fit. Sports Med.

      Volume: 1

    • NAID

      10031158921

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effects of exercise on macrophage function2012

    • Author(s)
      Kizaki, T. et al.
    • Journal Title

      J. Phy. Fit. Sports Med.

      Volume: 1

    • NAID

      10031158932

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of β2-agonists and exercise on β2-adrenergic receptor signaling in skeletal muscles2012

    • Author(s)
      Sato, S. et al.
    • Journal Title

      J. Phys. Fit. Sports Med.

      Volume: 1

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of exercise on the hexosamine biosynthetic pathway and glycosylation2012

    • Author(s)
      Shirato, K. et al.
    • Journal Title

      J. Phy. Fit. Sports Med.

      Volume: 1

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Exercise training and the promotion of neurogenesis and neurite outgrowth in the hippocampus.2012

    • Author(s)
      Sakurai, T. et al.
    • Journal Title

      J. Phy. Fit. Sports Med.

      Volume: 1

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of physical exercise on lipolysis in white adipocytes.2012

    • Author(s)
      Ogasawara, J. et al.
    • Journal Title

      J. Phy. Fit. Sports Med.

      Volume: 1

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of the effect of oligonol, a new lychee fruit-derived low molecular form of polyphenol, and epigallocatechin-3-gallate on lipolysis in rat primary adipocytes2011

    • Author(s)
      Ogasawara, J., Kitadate, K., Nishioka, H., Fujii, H., Sakurai, T., Kizaki, T., Izawa, T., Ishida, H. & Ohno, H.
    • Journal Title

      Phytother Res

      Volume: 25 Issue: 3 Pages: 467-471

    • DOI

      10.1002/ptr.3296

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Voluntary exercise attenuates obesity-associated inflammation through ghrelin expressed in macrophages2011

    • Author(s)
      Kizaki, T., Maegawa, T., Sakurai, T., Ogasawara, J., Ookawara, T., Oh-ishi, S., Izawa, T., Haga, S. & Ohno, H.
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 413 Issue: 3 Pages: 454-459

    • DOI

      10.1016/j.bbrc.2011.08.117

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of leucine zipper transcription factor-like protein 1(Lztfl1) in the attenuation of cognitive impairment by exercise training2011

    • Author(s)
      Sakurai, T., Ogasawara, J., Kizaki, T., Ishibashi, Y., Fujiwara, T., Akagawa, K., Izawa, T., Oh-ishi, S., Haga, S. & Ohno, H.
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 416 Issue: 1-2 Pages: 125-129

    • DOI

      10.1016/j.bbrc.2011.11.008

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of exercise training on the density of endothelial cells in the white adipose tissue of rats2011

    • Author(s)
      Hatano, D., Ogasawara, J., Endoh, S., Sakurai, T., Nomura, S., Kizaki, T., Ohno, H., Komabayashi, T. & Izawa, T.
    • Journal Title

      Scand. J. Med. Sci

      Volume: 21 Issue: 6 Pages: 115-121

    • DOI

      10.1111/j.1600-0838.2010.01176.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Voluntary exercise attenuates obesity-associated inflammation through ghrelin expressed in macrophages.2011

    • Author(s)
      Kizaki, T. et al.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 413 Pages: 454-459

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 富士登山時の自律神経応答と身体の電気伝導率2011

    • Author(s)
      長澤純一ほか
    • Journal Title

      登山医学

      Volume: 31 Pages: 145-152

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of the effect of oligonol, a new lychee fruit-derived low molecular form of polyphenol, and epigallocatechin-3-gallate on lipolysis in rat primary adipocytes.2011

    • Author(s)
      Ogasawara, J. et al.
    • Journal Title

      Phytother Res.

      Volume: 25 Pages: 467-471

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 食細胞の機能と低酸素環境2011

    • Author(s)
      大野秀樹ほか
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 55 Pages: 239-246

    • NAID

      40018745187

    • Related Report
      2011 Research-status Report
  • [Presentation] シンポジウム"脂肪蓄積と代謝異常に対する運動の効果―動物実験で得られた知見のヒトへの応用―":運動と脂肪細胞の働き2014

    • Author(s)
      小笠原準悦, 櫻井拓也, 石橋義永, 木崎節子, 白土健, 今泉和彦, 井澤鉄也, 大野秀樹
    • Organizer
      第160回日本体力医学会関東地方会
    • Place of Presentation
      調布
    • Year and Date
      2014-03-08
    • Related Report
      2013 Final Research Report
  • [Presentation] “脂肪蓄積と代謝異常に対する運動の効果―動物実験で得られた知見のヒトへの応用―”:運動と脂肪細胞の働き2014

    • Author(s)
      小笠原準悦ほか
    • Organizer
      第160回日本体力医学会関東地方会
    • Place of Presentation
      調布
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] A circadian clock gene Rev-erbαmodulates inflammatory functions of macrophages through negative regulation of monocyte chemoattractant protein-1 expression2013

    • Author(s)
      Kizaki, T., Sato, S. and Ohno, H
    • Organizer
      第42回日本免疫学会学術総会
    • Place of Presentation
      幕張
    • Year and Date
      2013-12-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 時計遺伝子Rev-erbαはMCP1遺伝子の発現を抑制しマクロファージ免疫機能を制御する2013

    • Author(s)
      佐藤章悟, 木崎節子, 櫻井拓也, 小笠原準悦, 石橋義永, 長澤純一, 桜井智野風, 井澤鉄也, 今泉和彦, 芳賀脩光, 大野秀樹
    • Organizer
      第68回日本体力医学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-09-21
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 水泳運動は前駆細胞からの褐色脂肪細胞化を促す2013

    • Author(s)
      小笠原準悦, 櫻井拓也, 木崎節子, 佐藤章悟, 石橋義永, 井澤鉄也, 宮崎裕美, 斎藤大蔵, 十枝内厚次, 大石修司, 芳賀脩光, 大野秀樹
    • Organizer
      第68回日本体力医学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-09-21
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Inhibitory effect of ETAS against amyloid beta-induced cellular disorder in PC12 cells2013

    • Author(s)
      Ogasawara, J., Ito, T., Takanari, J., Sakurai, T., Kizaki, T., Sato, S., Ishibashi, Y., Nagasawa, J., Saito, D., Nakano, N., Izawa, T. and Ohno, H
    • Organizer
      21^<st> International Congress on Nutrition and Integrative Medicine
    • Place of Presentation
      Sapporo
    • Year and Date
      2013-07-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 運動は肥満による脂肪組織の線維化関連因子の発現増加を減弱させる2013

    • Author(s)
      櫻井拓也, 小笠原準悦, 木崎節子, 長澤純一, 芳賀脩光, 大野秀樹
    • Organizer
      第21回日本運動生理学会大会
    • Place of Presentation
      川越
    • Year and Date
      2013-07-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 持久性走トレーニングによる白色脂肪細胞の脂肪分解反応の亢進にはATGLの発現変化が関与する2013

    • Author(s)
      小笠原準悦, 櫻井拓也, 佐藤章悟, 石橋義永, 長澤純一, 大石修司, 芳賀脩光, 井澤鉄也, 木崎節子, 大野秀樹
    • Organizer
      第158回日本体力医学会関東地方会
    • Place of Presentation
      新座
    • Year and Date
      2013-07-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 水泳運動により誘導される肩甲骨周囲骨格筋群の褐色脂肪細胞化の検討2013

    • Author(s)
      小笠原準悦, 櫻井拓也, 木崎節子, 佐藤章悟, 石橋義永, 井澤鉄也, 斎藤大蔵, 大石修司, 芳賀脩光, 大野秀樹
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢
    • Year and Date
      2013-03-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 運動は肥満による脂肪組織の繊維化関連因子の発現増加を減弱させる2013

    • Author(s)
      桜井拓也ほか
    • Organizer
      第21回日本運動生理学会大会
    • Place of Presentation
      川越
    • Related Report
      2013 Annual Research Report
  • [Presentation] Inhibitory Effect of ETAS against Amyloid Beta-induced Cellular Disorder in PC12 Cells2013

    • Author(s)
      Ogasawara, J., et al.
    • Organizer
      The 21th International Congress on Nutrition and Integrative Medicine
    • Place of Presentation
      Sapporo
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effect of Frequeint Antioxidant Supplementaion on Oxidative Stress When Climbing Mt. Fuji.2013

    • Author(s)
      Nagasawa, J., et al.
    • Organizer
      The 21th International Congress on Nutrition and Integrative Medicine
    • Place of Presentation
      Sapporo
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脂肪組織および骨格筋組織における時計遺伝子と脂質代謝関連遺伝子の関連性2013

    • Author(s)
      加藤久詞ほか
    • Organizer
      第68回日本体力医学会大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 登山時の低酸素ストレス応答2013

    • Author(s)
      長澤純一ほか
    • Organizer
      第68回日本体力医学会大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] The orphan nuclear receptor Rev-erb&#61537; regulates inflammatory responses of macrophages through monocyte chemoattractant protein 12013

    • Author(s)
      Kizaki, T., et al.
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Related Report
      2013 Annual Research Report
  • [Presentation] 酸化処理アスパラガス抽出物は神経細胞において抗ストレス作用をもつ.2013

    • Author(s)
      櫻井拓也ほか
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢
    • Related Report
      2012 Research-status Report
  • [Presentation] 水泳運動により誘導される肩甲骨周囲骨格筋群の褐色脂肪細胞化の検討.2013

    • Author(s)
      小笠原準悦ほか
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢
    • Related Report
      2012 Research-status Report
  • [Presentation] The enzyme-treated Asparagus offcinalis extract shows anti-stress effects in neuronal cells and prevents cognitive impairment in senescense-accelerated mice2012

    • Author(s)
      Sakurai, T., Kitadate, K., Nishioka, H., Wakame, K., Fujii, H., Ogasawara, J., Kizaki, T., Sato, S., Ishibashi, Y., Fujiwara, T., Akagawa, K., Imaizumi, K., Saitoh, D., Izawa, T. and Ohno, H
    • Organizer
      The 6th International Niigata Simposium on Diet and Health
    • Place of Presentation
      Niigata
    • Year and Date
      2012-10-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 運動は肥満による脂肪組織のデルマトポンチン発現増加を減弱させる2012

    • Author(s)
      櫻井拓也, 小笠原準悦, 木崎節子, 佐藤章悟, 井澤鉄也, 芳賀脩光, 今泉和彦, 大石修司, 大野秀樹
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      岐阜
    • Year and Date
      2012-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 水泳運動は骨格筋前駆細胞から褐色脂肪細胞への分化を促進する2012

    • Author(s)
      小笠原準悦, 櫻井拓也, 木崎節子, 井澤鉄也, 武政徹, 芳賀脩光, 長澤純一, 大野秀樹
    • Organizer
      第20回日本運動生理学会大会
    • Place of Presentation
      つくば
    • Year and Date
      2012-07-29
    • Related Report
      2013 Final Research Report
  • [Presentation] The extract from stems of Asparagus offcinalis enhances the expression of heat shock proteins and shows anti-stress effects in neural cells2012

    • Author(s)
      Sakurai, T., Kitadate, K., Nishioka, H., Wakame, K., Fujii, H., Ogasawara, J. Kizaki, T., Sato, S., Ishibashi, Y., Imaizumi, K., Saitoh, D., Izawa, T. and Ohno, H
    • Organizer
      The 20th Internathional Congress on Nutrition and Integrative Medicine
    • Place of Presentation
      Sapporo
    • Year and Date
      2012-07-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 水泳運動は骨格筋前駆細胞から褐色脂肪細胞への分化シグナルを促進する2012

    • Author(s)
      小笠原準悦, 櫻井拓也, 木崎節子, 石橋義永, 炭谷由計, 井澤鉄也, 石田均, 鈴木健二, 芳賀脩光, 大野秀樹
    • Organizer
      第82回日本衛生学会学術総会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-25
    • Related Report
      2013 Final Research Report
  • [Presentation] The extract from stems of Asparagus offcinalis enhances the expression of heat shock proteins and shows anti-stress effects in neural cells.2012

    • Author(s)
      Sakurai, T., et al.
    • Organizer
      The 20th Internathional Congress on Nutrition and Integrative Medicine
    • Place of Presentation
      Sapporo
    • Related Report
      2012 Research-status Report
  • [Presentation] 水泳運動は骨格筋前駆細胞から褐色脂肪細胞への分化を促進する.2012

    • Author(s)
      小笠原準悦ほか
    • Organizer
      第20回日本運動生理学会大会
    • Place of Presentation
      つくば
    • Related Report
      2012 Research-status Report
  • [Presentation] 酵素処理アスパラガス抽出物ETASTMによる抗ストレス作用2012

    • Author(s)
      櫻井拓也ほか
    • Organizer
      第16回日本統合医療学会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 運動は肥満による脂肪組織のデルマトポンチン発現増加を減弱させる.2012

    • Author(s)
      櫻井拓也ほか
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      岐阜
    • Related Report
      2012 Research-status Report
  • [Presentation] The enzyme-treated Asparagus offcinalis extract shows anti-stress effects in neuronal cells and prevents cognitive impairment in senescense-accelerated mice.2012

    • Author(s)
      Sakurai, T., et al.
    • Organizer
      The 6th International Niigata Simposium on Diet and Health
    • Place of Presentation
      Niigata
    • Related Report
      2012 Research-status Report
  • [Presentation] Oligonolは神経細胞において小胞体ストレス減弱作用をもつ2012

    • Author(s)
      桜井拓也ほか
    • Organizer
      第82回日本衛生学会学術総会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] 水泳運動は骨格筋前駆細胞から褐色脂肪細胞への分化のシグナルを促進する2012

    • Author(s)
      小笠原準悦ほか
    • Organizer
      第82回日本衛生学会学術総会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] Preventive effects of Oligonol on cognitive impairment in senescence-accelerated mice and identification on its molecular target in hippocampus2011

    • Author(s)
      Sakurai, T., Kitadate, K., Nishioka, H., Wakame, K., Ogasawara, J., Kizaki, T., Ishibashi, Y., Fujiwara, T., Akagawa, K., Nakano, N., Izawa, T. and Ohno, H
    • Organizer
      The 19th International Congress on Nutrition and Integrative Medicine
    • Place of Presentation
      Sapporo
    • Year and Date
      2011-10-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 骨格筋から褐色脂肪細胞への分化機構に及ぼす寒冷曝露と水泳運動の効果2011

    • Author(s)
      小笠原準悦, 櫻井拓也, 木崎節子, 石橋義永, 住谷由計, 井澤鉄也, 宮崎裕美, 大石修司, 芳賀脩光, 大野秀樹
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      下関
    • Year and Date
      2011-09-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 運動は老化促進モデルマウスの認知機能障害を予防する2011

    • Author(s)
      櫻井拓也, 小笠原準悦, 木崎節子, 井澤鉄也, 長澤純一, 芳賀脩光, 大野秀樹
    • Organizer
      第19回日本運動生理学会大会
    • Place of Presentation
      徳島
    • Year and Date
      2011-08-26
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Preventive effects of Oligonol on cognitive impairment in senescence-accelerated mice and identification on its molecular target in hippocampus.2011

    • Author(s)
      Sakurai, T. et al.
    • Organizer
      19th International Congress on Nutrition and Integrative Medicine
    • Place of Presentation
      Sapporo
    • Related Report
      2011 Research-status Report
  • [Presentation] (大会長指名講演)抗体医薬を支える免疫の仕組みー自然免疫の驚異ー2011

    • Author(s)
      木崎節子
    • Organizer
      第31回日本核医学技術学会総会学術大会(招待講演)
    • Place of Presentation
      つくば
    • Related Report
      2011 Research-status Report
  • [Presentation] Oligonolは神経細胞において小胞体ストレスを限弱させる.2011

    • Author(s)
      櫻井拓也ほか
    • Organizer
      第9回日本予防医学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 骨格筋から褐色脂肪細胞への分化機構に及ぼす寒冷曝露と水泳運動の効果.2011

    • Author(s)
      小笠原準悦ほか
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      下関
    • Related Report
      2011 Research-status Report
  • [Presentation] 脂肪細胞の脂肪分解反応に及ぼす新規カテキン型ポリフェノール複合体Oligonolの効果.2011

    • Author(s)
      小笠原準悦ほか
    • Organizer
      第21回体力・栄養・免疫学会大会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 富士登山時の自律神経応答と身体の電気伝導率2011

    • Author(s)
      長澤純一ほか
    • Organizer
      第31回日本登山医学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 運動は骨格筋から褐色脂肪細胞への分化を活性化するか2011

    • Author(s)
      小笠原準悦ほか
    • Organizer
      第40回杏林医学会総会
    • Place of Presentation
      三鷹
    • Related Report
      2011 Research-status Report
  • [Presentation] 持久性走トレーニングによる白色脂肪細胞の脂肪分解反応の亢進にはATGLの発現変化が関与する

    • Author(s)
      小笠原準悦ほか
    • Organizer
      第158回日本体力医学会関東地方会
    • Place of Presentation
      新座
    • Related Report
      2013 Annual Research Report
  • [Presentation] 運動は骨格筋前駆細胞から褐色脂肪細胞への分化を誘導するか:肥満予防・治療への応用

    • Author(s)
      小笠原準悦ほか
    • Organizer
      第42回杏林医学会総会
    • Place of Presentation
      三鷹
    • Related Report
      2013 Annual Research Report
  • [Presentation] 運動するとなぜ痩せる?~白色脂肪ではいったい何がおこるのか~.

    • Author(s)
      小笠原準悦ほか
    • Organizer
      第14回日本体力医学会北海道地方会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 酸化処理アスパラガス抽出物は神経細胞障害を減弱させ、老化促進モデルマウスの認知機能障害を予防する.

    • Author(s)
      櫻井拓也ほか
    • Organizer
      第41回杏林医学会総会
    • Place of Presentation
      三鷹
    • Related Report
      2012 Research-status Report
  • [Book] 身体の活性酸素消去を高める方法, 活性酸素の本当の姿2014

    • Author(s)
      大野秀樹, 木崎節子 (鈴木敬一郎編)
    • Publisher
      (有)ナップ
    • Related Report
      2013 Final Research Report
  • [Book] 活性酸素の本当の姿2014

    • Author(s)
      大野秀樹、木崎節子
    • Total Pages
      175
    • Publisher
      ナップ
    • Related Report
      2013 Annual Research Report
  • [Book] マクロファージは褐色脂肪組織に燃料を補給する, ここまでわかった燃える褐色脂肪の不思議2013

    • Author(s)
      木崎節子, 佐藤章悟, 大河原知水 (斎藤昌之, 大野秀樹編)
    • Total Pages
      56
    • Publisher
      (有)ナップ
    • Related Report
      2013 Final Research Report
  • [Book] UCP2は活性酸素を制御する, ここまでわかった燃える褐色脂肪の不思議2013

    • Author(s)
      木崎節子, 鈴木健二, 芳賀脩光 (斎藤昌之, 大野秀樹編)
    • Total Pages
      100
    • Publisher
      (有)ナップ
    • Related Report
      2013 Final Research Report
  • [Book] 水泳は褐色脂肪組織のグッド・ストレッサー, ここまでわかった燃える褐色脂肪の不思議2013

    • Author(s)
      大野秀樹, 上野伸正, 木崎節子 (斎藤昌之, 大野秀樹編)
    • Total Pages
      150
    • Publisher
      (有)ナップ
    • Related Report
      2013 Final Research Report
  • [Book] ここまでわかった燃える褐色脂肪の不思議2013

    • Author(s)
      木崎節子ほか
    • Total Pages
      158
    • Publisher
      ナップ
    • Related Report
      2013 Annual Research Report
  • [Book] 第23章燃焼系素材と運動, 機能性食品素材と運動療法-生活習慣病予防と運動機能維持向上を目指して-2012

    • Author(s)
      大野秀樹, 櫻井拓也, 小笠原準悦, 石橋義永, 木崎節子 (大澤俊彦, 佐藤祐造監修)
    • Publisher
      大阪シーエムシー出版
    • Related Report
      2013 Final Research Report
  • [Book] Proceedings 20th International Congress on Nutrition and Integrative Medicine2012

    • Author(s)
      櫻井拓也ほか
    • Total Pages
      132
    • Publisher
      アミノアップ化学
    • Related Report
      2012 Research-status Report
  • [Book] 機能性食品素材と運動療法ー生活習慣病予防と運動機能維持向上を目指してー2012

    • Author(s)
      大野秀樹ほか
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Research-status Report
  • [Book] 明治生命厚生事業団第27回健康医科学研究助成論文集2012

    • Author(s)
      桜井拓也ほか
    • Total Pages
      156
    • Publisher
      東京六法出版
    • Related Report
      2011 Research-status Report
  • [Book] エネルギースタンドとしての脂肪組織, 脂肪組織のエクササイズバイオロジー一冊まるごと脂肪組織と運動の話2011

    • Author(s)
      小笠原準悦, 木崎節子, 石橋義永, 芳賀脩光, 大野秀樹 (井澤鉄也, 駒林隆夫編)
    • Publisher
      (有)ナップ
    • Related Report
      2013 Final Research Report
  • [Book] 内分泌器官としての脂肪組織:アデイポカインの分泌, 脂肪組織のエクササイズバイオロジー一冊まるごと脂肪組織と運動の話2011

    • Author(s)
      櫻井拓也, 小笠原準悦, 木崎節子, 炭谷由計, 石田均, 大野秀樹 (井澤鉄也, 駒林隆夫編)
    • Publisher
      (有)ナップ
    • Related Report
      2013 Final Research Report
  • [Book] Proceedings 19th International Congres on Nutrition and Integrative Medicine2011

    • Author(s)
      桜井拓也ほか
    • Total Pages
      174
    • Publisher
      アミノアップ化学
    • Related Report
      2011 Research-status Report
  • [Book] 公益財団法人中冨健康科学振興財団第22回研究助成業績集2011

    • Author(s)
      小笠原準悦ほか
    • Total Pages
      158
    • Publisher
      医薬ジャーナル社
    • Related Report
      2011 Research-status Report
  • [Book] 脂肪細胞のエクササイズバイオロジー 1冊まるごと脂肪組織と運動の話2011

    • Author(s)
      桜井拓也ほか
    • Total Pages
      180
    • Publisher
      ナップ
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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