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Development of evaluation of health effects and environmental carcinogens exposure in molecular epidemiology

Research Project

Project/Area Number 23590754
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hygiene
Research InstitutionShowa University

Principal Investigator

YAMANO Yuko  昭和大学, 医学部, 准教授 (30167580)

Co-Investigator(Renkei-kenkyūsha) HARA Kunio  帝京平成大学, 地域医療学部, 教授 (40250047)
ICHIBA Masayoshi  佐賀大学, 医学部, 教授 (60184628)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords環境疫学 / 環境発がん物質 / 生物学的モニタリング / 多環芳香族炭化水素類
Research Abstract

Polycyclic aromatic hydrocarbons (PAHs) are multiple compounds which include many carcinogens. We conducted a cross-sectional study in steel plant workers (n=57), to identify biomarkers that reflect the carcinogenicity of PAHs. Level of personal exposure to 15 PAHs was measured using GC-MS. Urinary metabolites analyzed using HPLC with a fluorescence detector and LC-MSMS. Eleven known urinary metabolites 1-, 2-hydroxy(OH)naphthalene, 2-OH fluorene, 1-, 2-, 3-, 9-OH phenanthrene, 1-OH pyrene, 3-OH benz[a]anthracene, 6-OH chrysene, 3-OH benzo[a]pyrene were detected. The highest correlation was between Total-PAHs and urinary 2-OH naphthalene. Among the detected urinary metabolites, 1-OH pyrene was found to the greatest correlation with the "Sigma carcinogenic potency of PAHs" (sum of seven carcinogenic PAHs calculated from levels of personal PAHs and relative potency factors), indicated that urinary 1-OH pyrene was the most comprehensive carcinogenic biomarker of exposure to PAHs.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (7 results)

All 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results)

  • [Journal Article] Urinary 1-hydroxypyrene as a comprehensive carcinogenic biomarker of exposure to polycyclic aromatic hydrocarbons: a cross-sectional study of coke oven workers in China2013

    • Author(s)
      Yuko YAMANO, Kunio HARA, Masayoshi ICHIBA, Tomoyuki HANAOKA, Guowei PAN and Toshio NAKADATE
    • Journal Title

      Journal of the International Archives of Occupational and Environmental Health

      Volume: Online ahead of print Issue: 7 Pages: 705-713

    • DOI

      10.1007/s00420-013-0913-6

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 多環芳香族炭化水素類のバイオマーカーに関する研究1:発がん強度を考慮したバイオマーカー2014

    • Author(s)
      山野優子, 原邦夫, 市場正良, 花岡知之, 潘国偉, 中館俊夫
    • Organizer
      第87回日本産業衛生学会
    • Place of Presentation
      岡山コンベンションセンター(岡山県岡山市)
    • Related Report
      2013 Final Research Report
  • [Presentation] 多環芳香族炭化水素類のバイオマーカーに関する研究2:作業・保護具・生活習慣の影響2014

    • Author(s)
      原邦夫, 山野優子, 市場正良, 花岡知之, 潘国偉, 中館俊夫
    • Organizer
      第87回日本産業衛生学会
    • Place of Presentation
      岡山コンベンションセンター(岡山県岡山市)
    • Related Report
      2013 Final Research Report
  • [Presentation] 多環芳香族炭化水素類のバイオマーカーに関する研究3:尿中未変化体濃度2014

    • Author(s)
      市場正良, 山本忍, 山野優子, 原邦夫, 宮崎博喜, 松本明子, 花岡知之, 潘国偉, 中館俊夫
    • Organizer
      第87回日本産業衛生学会
    • Place of Presentation
      岡山コンベンションセンター(岡山県岡山市)
    • Related Report
      2013 Final Research Report
  • [Presentation] 多環芳香族炭化水素類のバイオマーカーに関する研究 1:発がん強度を考慮したバイオマーカー2014

    • Author(s)
      山野優子、原 邦夫、市場正良、花岡知之、潘 国偉、中館俊夫
    • Organizer
      第87回 日本産業衛生学会
    • Place of Presentation
      岡山コンベンションセンター (岡山県岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多環芳香族炭化水素類のバイオマーカーに関する研究 2:作業・保護具・生活習慣の影響2014

    • Author(s)
      原 邦夫、山野優子、市場正良、花岡知之、潘 国偉、中館俊夫
    • Organizer
      第87回 日本産業衛生学会
    • Place of Presentation
      岡山コンベンションセンター (岡山県岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多環芳香族炭化水素類のバイオマーカーに関する研究 3:尿中未変化体濃度2014

    • Author(s)
      市場正良、山本 忍、山野優子、原 邦夫、宮崎博喜、松本明子、花岡知之、潘 国偉、中館俊夫
    • Organizer
      第87回 日本産業衛生学会
    • Place of Presentation
      岡山コンベンションセンター (岡山県岡山市)
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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