Effects of n-3 unsaturated fatty acid on ischemic heart disease: evaluation of LDL choesterol function
| Project/Area Number |
23590757
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAO Ken 日本大学, 医学部研究所, 教授 (90207978)
HIRAYAMA Atsushi 日本大学, 医学部, 教授 (50459880)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | エイコサペンタエン酸 / ドコサヘキサエン酸 / 冠動脈疾患 / 血清脂質 / n-3系不飽和脂肪酸 / リポタンパクコレステロール |
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| Research Abstract |
Hypertriglyceridemic subjects were randomly assigned to a control group or an EPA group.In the EPA group,the serum LDL-C and HDL-C levels remained unchanged, but there was a significant increase in LDL size and a significant decrease in TG-rich lipoproteins (TRLs) levels. Elevation of EPA/AA was independent variable associated with the increase in LDL size. Negative correlations were found between TRLs and LDL particle size. EPA administration increases LDL size by improving TG metabolism, and EPA/AA may be useful markers of increased LDL size.The cross-sectional study suggested that higher serum levels of EPA and DHA derived from fish consumption are associated with lower coronary artery disease prevalence even in an urban environment in Japan. Higher EPA and DHA levels were independent variables of a higher apoA-1 level.
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Report
(4 results)
Research Products
(21 results)
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[Presentation] Fish Consumption-derived High Eicosapentaenoic Acid / Arachidonoenic Acid Ratio May Reduce Atherosclerotic Cardiovascular Risk : Implication of Atherosclerotic Cardiovascular Biomarker2013
Author(s)
Tani, Nagao, Kawamata, Furuya, Takahashi, Iida, Matsumoto, Kobari, Washio, Kazato, Hirayama
Organizer
The 77th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
横浜
Year and Date
2013-03-17
Related Report
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[Presentation] Association of N-3 Polyunsaturated Fatty Acids and Coronary Artery Disease Morbidity with Atherosclerosis-Related Markers2013
Author(s)
Tani, Nagao, Kawamata, Furuya, Takahashi, Iida, Matsumoto, Kobari, Washio, Kazato, Hirayama
Organizer
The 77th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
横浜
Year and Date
2013-03-16
Related Report
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[Presentation] Highly Purified Eicosapentaenoic Acid May Increase the LDL-particle Size by Improving Triglyceride Metabolism in Patients with Hypertriglyceridemia.
Author(s)
Shigemasa Tani, Ken Nagao, Hirofumi Kawamata, Shingo Furuya, Hiroshi Takahashi, Kiyoshi Iida, Michiaki Matsumoto, Chikara Kobari, Takehiko Washio, Atsushi Hirayama
Organizer
he 77th Annual Scientific Meeting of the Japanese Circulation Society,
Place of Presentation
横浜
Related Report
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[Presentation] Association of N-3 Polyunsaturated Fatty Acids and Coronary Artery Disease Morbidity with Atherosclerosis-Related Markers
Author(s)
Shigemasa Tani, Ken Nagao, Hirofumi Kawamata, Shingo Furuya, Hiroshi Takahashi, Kiyoshi Iida, Michiaki Matsumoto, Chikara Kobari, Takehiko Washio, Koichiro Kazato, Atsushi Hirayama
Organizer
The 77th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
横浜
Related Report
-
[Presentation] Fish Consumption-derived High Eicosapentaenoic Acid / Arachidonoenic Acid Ratio May Reduce Atherosclerotic Cardiovascular Risk: Implication of Atherosclerotic Cardiovascular Biomarker
Author(s)
Shigemasa Tani, Ken Nagao, Hirofumi Kawamata, Shingo Furuya, Hiroshi Takahashi, Kiyoshi Iida, Michiaki Matsumoto, Chikara Kobari, Takehiko Washio, Koichiro Kazato, Atsushi Hirayama
Organizer
The 77th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
横浜
Related Report
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