| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Amosite (AM) is one of the principal asbestos that was used in Japan. This AM is converted to crystalline silica and iron oxides by thermal treatment at 1000 °C or more, and the proportion of these compositions are different by thermal treatment condition. We conducted cytotoxicity tests of thermal transformed AM samples and intratracheal administration tests in rats to evaluate the role of crystal structure (crystalline silica and iron oxides) in the biological effects of thermal decomposition products of AM. When the material was thermal transformed at over 1200 °C, acute respiratory effects were reduced but chronic respiratory effects were increased in spite of fiber morphology of thermally transformed AM. These results suggested that the fiber morphology and crystal structure (especially crystalline silica) influence the chronic respiratory effects induced by thermal decomposition products of AM.
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