| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
We examined the possible allergenicity for dead Anisakis simplex larvae contaminated in seafood, except for the cases by infection with live A. simplex larvae. The dead A. simplex larvae treated with heat, frozen, cutting or homogenizing could not have possibility for inducing immune response in non-sensitized rats by at least once oral inoculation of them. However, IgE antibody specific to A. simplex larvae was produced and elevated in sensitized-rats after inoculation of Anisakis homogenates, and that its antigen was detected in sera in those rats, suggesting that possible allergenicity especially urticaria could be occurred in sensitized individuals after ingestion of dead A. simplex larvae.
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