The effects of maternal exposure of persistent organochlorine pesticides on allergic and infection's symptoms in infancy

• Project/Area Number: 23590769
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Hokkaido University (2012-2013); Junior College, Asahikawa University (2011)
• Principal Investigator: KANAZAWA Ayako 北海道大学, 環境健康科学研究教育センター, 客員研究員 (90201425)
• Co-Investigator(Kenkyū-buntansha): HANDA Yasushi 北海道大学, 遺伝子病制御研究所, 客員研究員 (70571785) ; MIYASHITA Chihiro 北海道大学, 環境健康科学研究教育センター, 特任助教 (70632389)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 母子保健 / ヒト次世代影響 / 難分解性有機塩素系農薬 / 喘息 / アトピー / 感染症

Research Abstract

Previous studies suggest that persistent organochlorine (POC) pesticides may contribute to endocrine disruption. The purpose of this study was to investigate the association between POCs levels in maternal blood and the risk of allergies in infancy. Between 2002 and 2005, 514 pregnant women were recruited in Sapporo Toho Hospital, and 29 POC pesticides in 320 whole blood samples were measured. No associations between POC pesticides levels and allergic symptoms at 18 month of age were observed in adjusted logistic regression analysis. At background levels, prenatal exposure to POC pesticides may alter immune function during childhood. Therefore, more long-term observations are needed to assess whether developmental exposure may result in allergic diseases in later childhood.

Research Products

• [Journal Article] Association of Mechanical Ventilation and Flue Use in Heaters With Asthma Symptoms in Japanese Schoolchildren: A Cross-Sectional Study in Sapporo, Japan (2014)
  • Author(s): Cong S., Araki A., Ukawa S., Ait Bamai Y., Tajima S., Kanazawa A., Yuasa M., Tamakoshi A., Kishi R
  • Journal Title: Journal of Epidemiology Volume: 24 Issue: 3 Pages: 230-238
  • DOI: 10.2188/jea.JE20130135
  • NAID: 130003392103
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Open Access
• [Journal Article] Phosphorus flame retardants in indoor dust and their relation to asthma and allergies of inhabitants (2014)
  • Author(s): Araki A., Saito I., Kanazawa A., Morimoto K., Nakayama K., Shibata E., Tanaka M., Takigawa T., Yoshimura T., Chikara H., Saijo Y., Kishi R
  • Journal Title: Indoor Air Volume: 24 Issue: 1 Pages: 3-15
  • DOI: 10.1111/ina.12054
  • Peer Reviewed / Open Access
• [Journal Article] Exposure to house dust phthalates in relation to asthma and allergies in both children and adults (2014)
  • Author(s): Ait Bamai Y., Shibata E., Saito I., Araki A., Kanazawa A., Morimoto K., Nakayama K., Tanaka M., Takigawa T., Yoshimura T., Chikara H., Saijo Y., Kishi R
  • Journal Title: Sci Total Environ Volume: 485-486C Pages: 153-163
  • DOI: 10.1016/j.scitotenv.2014.03.059
  • NAID: 120005425358
  • Peer Reviewed / Open Access
• [Journal Article] The association between mechanical ventilation, flue use in heaters and asthma symptoms in Japanese schoolchildren - A cross-sectional study in Sapporo, Japan (2014)
  • Author(s): Cong S., Araki A., Ukawa S., Ait Bamai Y., Tajima S., Kanazawa A., Yuasa M., Tamakoshi A., Kishi R.
  • Journal Title: J Epidemiol Volume: in press
  • Peer Reviewed
• [Journal Article] The relationship between atopic dermatitis and indoor environmental factors: a cross-sectional study among Japanese elementary school children (2013)
  • Author(s): Ukawa S, Araki A, Kanazawa A, Yuasa M, Kishi R
  • Journal Title: Int Arch Occup Environ Health Volume: - Issue: 7 Pages: 777-787
  • DOI: 10.1007/s00420-012-0814-0
  • Peer Reviewed
• [Journal Article] Ten years of progress in the Hokkaido birth cohort study on environment and children's health : cohort profile--updated 2013. (2013)
  • Author(s): Kishi R, Kobayashi S, Ikeno T, Araki A, Miyashita C, Itoh S, Sasaki S, Okada E, Kobayashi S, Kashino I, Itoh K, Nakajima S ; Members of the Hokkaido Study on Environment and Children's Health.
  • Journal Title: Environmental Health and Preventive Medicine Volume: 18 Issue: 6 Pages: 429-450
  • DOI: 10.1007/s12199-013-0357-3
  • Peer Reviewed
• [Journal Article] 札幌市の小学生4,500名を対象とした住環境とアトピー性皮膚炎に関する調査 (2013)
  • Author(s): 鵜川重和, 荒木敦子, 金澤文子, 湯浅資之, 岸玲子
  • Journal Title: 北海道医学雑誌 Volume: 88 Pages: 95-95
• [Journal Article] ハウスダスト中フタル酸エステルと住環境との関連 (2013)
  • Author(s): アイツバマイゆふ, 荒木敦子, 河合俊夫, 坪井樹, 斎藤育江, 吉岡英治, 金澤文子, 多島秀司, 叢石, 玉腰暁子, 岸玲子
  • Journal Title: 北海道医学雑誌 Volume: 88 Pages: 198-198
• [Journal Article] Blood persistent organochlorine pesticides of pregnant women relating to their characteristics in the Hokkaido Study on environment and children's health (2012)
  • Author(s): Kanazawa A, Miyashita C, Okada E, Kobayashi S, Washino N, Sasaki S, Yoshioka E, Mizutani F, Chisaki Y, Saijo Y, Kishi R.
  • Journal Title: Sci Total Environ. Volume: (In press) Pages: 73-82
  • DOI: 10.1016/j.scitotenv.2012.02.073
  • Peer Reviewed
• [Journal Article] The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes (2012)
  • Author(s): Araki A., Kanazawa A., Kawai T., Eitaki Y., Morimoto K., Nakayama K., Shibata E., Tanaka M., Takigawa T., Yoshimura T., Chikara H., Saijo Y., Kishi R
  • Journal Title: Sci Total Environ Volume: 423 Pages: 18-26
  • DOI: 10.1016/j.scitotenv.2012.02.026
  • NAID: 120004027252
  • Peer Reviewed
• [Journal Article] The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes. (2012)
  • Author(s): Araki A, Kanazawa A, Kawai T, Eitaki Y, Morimoto K, Nakayama K, Shibata E, Tanaka M, Takigawa T, Yoshimura T, Chikara H, Saijo Y, Kishi R.
  • Journal Title: Sci Total Environ Volume: 423 Pages: 18-26
  • NAID: 120004027252
  • Peer Reviewed
• [Journal Article] Blood persistent organochlorine pesticides in pregnant women in relation to physical and environmental variables in The Hokkaido Study on Environment and Children's Health. (2012)
  • Author(s): Kanazawa A, Miyasita C, Okada E, Kobayashi S, Washino N, Sasaki S, Yoshioka E, Mizutani F, Chisaki Y, Saijo Y, Kishi R.
  • Journal Title: Sci Total Environ. Volume: 426 Pages: 73-82
  • Peer Reviewed
• [Journal Article] 北海道の妊婦の全血中POPs系農薬の濃度環境と子どもの健康に関する北海道研究 (2011)
  • Author(s): 金澤文子, 宮下ちひろ, 岡田恵美子, 小林澄貴, 鷲野孝揚, 湯浅資之, 佐々木成子, 吉岡英治, 水谷太, 苣木洋一, 岸玲子
  • Journal Title: 日本衛生学雑誌 Volume: 66 Pages: 95-107
  • NAID: 10029363979
  • URL: http://search.jamas.or.jp/link/ui/2011192746
  • Peer Reviewed
• [Presentation] 札幌市内小学生の自宅における暖房、および機械換気の有無と児童の喘息 (2013)
  • Author(s): 叢石, 荒木敦子, 鵜川重和, アイツバマイゆふ, 多島秀司, 金澤文子, et al
  • Organizer: 第65回北海道公衆衛生学会
  • Place of Presentation: 札幌
• [Presentation] 尿中フタル酸代謝物濃度とハウスダスト中フタル酸エステル濃度との関連:札幌市児童における調査 (2013)
  • Author(s): アイツバマイゆふ, 荒木敦子, 河合俊夫, 坪井樹, 多島秀司, 叢石, 湯浅資之, 金澤文子, et al
  • Organizer: 第65回北海道公衆衛生学会
  • Place of Presentation: 札幌
• [Presentation] 札幌市内小学生の自宅における暖房、および機械換気の有無と児童の喘息 (2013)
  • Author(s): 叢石, 荒木敦子, 鵜川重和, アイツバマイゆふ, 多島秀司, 金澤文子, 湯浅資之, 玉腰暁子, 岸玲子
  • Organizer: 第65回北海道公衆衛生学会
  • Place of Presentation: 札幌市生涯学習センター ちえりあ（札幌）
• [Presentation] 尿中フタル酸代謝物濃度とハウスダスト中フタル酸エステル濃度との関連：札幌市児童における調査 (2013)
  • Author(s): アイツバマイゆふ, 荒木敦子, 河合俊夫, 坪井樹, 多島秀司, 叢石, 湯浅資之, 金澤文子, 玉腰暁子, 岸玲子
  • Organizer: 第65回北海道公衆衛生学会
  • Place of Presentation: 札幌市生涯学習センター ちえりあ（札幌）
• [Presentation] 自宅住環境とアトピー性皮膚炎に関する調査-札幌市の小学生4,500名を対象として- (2011)
  • Author(s): 鵜川重和, 荒木敦子, 金澤文子, et al
  • Organizer: 第63回北海道公衆衛生学会
  • Place of Presentation: 札幌
• [Presentation] 自宅住環境とアトピー性皮膚炎に関する調査-札幌市の小学生4,500名を対象として. (2011)
  • Author(s): 鵜川重和、荒木敦子、金澤文子、湯浅資之、アイツバマイゆふ、吉岡英治、叢石、 多島秀司、岸玲子
  • Organizer: 第63回北海道公衆衛生学会
  • Place of Presentation: 札幌市
• [Remarks] 環境健康科学研究教育センターwebサイト研究業績
  • URL: http://www.cehs.hokudai.ac.jp/research/yearly/
• [Remarks] 環境健康科学研究教育センター成果発信webサイト「環境と健康ひろば」
  • URL: http://www.cehs.hokudai.ac.jp/hiroba/
• [Remarks] 環境健康科学研究教育センター 研究業績
  • URL: http://www.cehs.hokudai.ac.jp/research/yearly/
• [Remarks] 環境と健康ひろば
  • URL: http://www.cehs.hokudai.ac.jp/hiroba/
• [Remarks] 北海道大学環境健康科学研究教育センター
  • URL: http://www.cehs.hokudai.ac.jp/index.html