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A study on objective assessment of subjective stress by using neurophysiological indicators

Research Project

Project/Area Number 23590772
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Public health/Health science
Research InstitutionAkita University

Principal Investigator

MURATA Katsuyuki  秋田大学, 医学(系)研究科(研究院), 教授 (80157776)

Co-Investigator(Kenkyū-buntansha) IWATA Toyoto  秋田大学, 大学院医学系研究科, 助教 (00321894)
HORIGUCHI Hyogo  秋田大学, 大学院医学系研究科, 准教授 (90254002)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords主観的ストレス / 自律神経機能 / 心拍変動 / 客観的評価 / 健康管理 / 職場ストレス / 家庭内ストレス
Research Abstract

Three studies were done to assess subjective stress by using objective indicators, i.e., QTc time and QT index on ECG: (1) To test links between QT-related parameters and the covariates possibly distorting them, the averaged RR and QT intervals were measured for 150 students. Sex, BMI and fat percentage were significantly related to the Bazett's QTc or Rautaharju's QT index. (2) To clarify if specific dietary behavior is related to liver injury, liver markers and dietary behaviors such as lunch menu were explored in 1809 workmen. Habitual instant noodle ingestion and ethanol intake were associated with elevated ALT. (3) To assess the impact of job and domestic stresses on autonomic nervous function, the links between the QT-related parameters and job/domestic stresses were analyzed in 1809 workmen. QT index was associated with drinking habit, and domestic stress. In conclusion, QT index appears to be a more useful indicator than the QTc; also, QT index may reflect domestic stress.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (45 results)

All 2014 2013 2012 2011 Other

All Journal Article (22 results) (of which Peer Reviewed: 2 results) Presentation (20 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Suppression of erythropoietin induction by diethylstilbestrol in rats2014

    • Author(s)
      Horiguchi H, Oguma E, Sakamoto T, Murata K, Kayama F
    • Journal Title

      Arch Toxicol

      Volume: 88 Pages: 137-144

    • Related Report
      2013 Final Research Report
  • [Journal Article] Rationale and study of the Japan Environment and Children's Study (JECS)2014

    • Author(s)
      Kawamoto T, Nitta H, Murata K, Toda E, Tsukamoto N, Hasegawa M, Yamagata Z, Kayama F, Kishi R, Ohya Y, Saito H, Sago H, Okuyama M, Ogata T, Yokoya S, Koresawa Y, Shibata Y, Nakayama SF, Michikawa T, Takeuchi A, Satoh H
    • Journal Title

      BMC Public Health

      Volume: 14 Pages: 25-25

    • Related Report
      2013 Final Research Report
  • [Journal Article] Relationships between QT interval and heart rate variability at rest and the covariates in healthy young adults2013

    • Author(s)
      Arai K, Nakagawa Y, Iwata T, Hor iguchi H, Mur ata K
    • Journal Title

      Auton Neurosci

      Volume: 173 Pages: 53-57

    • Related Report
      2013 Final Research Report
  • [Journal Article] 水銀の毒性-汚染の歴史と研究の現状2013

    • Author(s)
      坂本峰至, 村田勝敬
    • Journal Title

      環境技術

      Volume: 42 Pages: 584-589

    • Related Report
      2013 Final Research Report
  • [Journal Article] Age-relevant renal effects of cadmium exposure through consumption of home-harvested rice in female Japansese farmers2013

    • Author(s)
      Horiguchi H, Oguma E, Sasaki S, Okubo H, Murakami K, Miyamoto K, Hosoi Y, Murata K, Kayama F
    • Journal Title

      Environ Int

      Volume: 56 Pages: 1-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] Visual evoked potentials in children prenatally exposed to methylmercury2013

    • Author(s)
      Yorifuji H, Murata K, Bjerve KS, Choi AL, Weihe P, Grandjean P
    • Journal Title

      Neurotoxico- logy

      Volume: 37 Pages: 15-18

    • Related Report
      2013 Final Research Report
  • [Journal Article] Performance tests of three types of air-sampling bags on organic solvent vapor retention2013

    • Author(s)
      Fukui Y, Kanemaru A, Nagasawa Y, Kawakami T, Iwata T, Murata K, Ohashi F, Ikeda M
    • Journal Title

      Ind Health

      Volume: 51 Pages: 347-352

    • NAID

      130004828692

    • Related Report
      2013 Final Research Report
  • [Journal Article] Relationships between trace element concentrations in chorionic tissue of placenta and umbilical cord tissue : potential use as indicators for prenatal exposure2013

    • Author(s)
      Sakamoto M, Yasutake A, Domingo JD, Chan HM, Kubota M, Murata K
    • Journal Title

      Environ Int

      Volume: 60 Pages: 106-111

    • Related Report
      2013 Final Research Report
  • [Journal Article] Quantitation of neonicotinoid metabolites in human urine using GC-MS2013

    • Author(s)
      Nomura H, Ueyama J, Kondo T, Saito I, Murata K, Iwata T, Wakusawa S, Kamijima M
    • Journal Title

      J Chromatorgr B Analyt Technol Biomed Life Sci

      Volume: 941 Pages: 109-115

    • Related Report
      2013 Final Research Report
  • [Journal Article] The association between dietary lifestyles and hepato- cellular injury in Japanese workers2013

    • Author(s)
      Iwata T, Arai K, Saito N, Mur ata K
    • Journal Title

      Tohoku J Exp Med

      Volume: 231 Pages: 257-263

    • NAID

      130004460098

    • Related Report
      2013 Final Research Report
  • [Journal Article] The Association between Dietary Lifestyles and Hepatocellular Injury in Japanese Workers2013

    • Author(s)
      Iwata T, Arai K, Saito N, Murata K
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 231 Issue: 4 Pages: 257-263

    • DOI

      10.1620/tjem.231.257

    • NAID

      130004460098

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationships between QT interval and heart rate variability at rest and the covariates in healthy youn adults.2013

    • Author(s)
      Kaori Arai, Yui Nakagawa, Toyoto Iwata, Hyogo Horiguchi, Katsuyuki Murata
    • Journal Title

      Autonomic Neuroscience: Basic and Clinical

      Volume: 173 Issue: 1-2 Pages: 53-57

    • DOI

      10.1016/j.autneu.2012.11.006

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 有害化学物質の手のふるえに及ぼす影響2012

    • Author(s)
      村田勝敬, 岩田豊人
    • Journal Title

      Peripheral Nerve

      Volume: 23 Pages: 141-145

    • Related Report
      2013 Final Research Report
  • [Journal Article] Hair- to-blood ratio and biological half-life of mercury : experimental study of methylmercury exposure through fish consumption in humans2012

    • Author(s)
      Yaginuma-Sakurai K, Murata K, Iwai-Shimada M, Nakai K, Kurokawa N, Tatsuta N, Satoh H
    • Journal Title

      J Toxicol Sci

      Volume: 37 Pages: 123-130

    • NAID

      10030037553

    • Related Report
      2013 Final Research Report
  • [Journal Article] Prenatal exposures to environmental chemicals and birth order as risk factors for child behavior problems2012

    • Author(s)
      Tatsuta N, Nakai K, Murata K, Suzuki K, Iwai- Shimada M, Yaginuma-Sakurai K, Kurokawa N, Nakamura T, Hosokawa T, Satoh H
    • Journal Title

      Environ Res

      Volume: 114 Pages: 47-52

    • Related Report
      2013 Final Research Report
  • [Journal Article] Urinary concentrations of organophosphorus insecticide metabolites in Japanese workers2012

    • Author(s)
      Ueyama J, Saito I, Kondo T, Taki T, Kimata A, Saito S, Ito Y, Murata K, Iwata T, Goto M, Shibata E, Wakusawa S, Kamijima M
    • Journal Title

      Chemosphere

      Volume: 87 Pages: 1403-1409

    • Related Report
      2013 Final Research Report
  • [Journal Article] Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age2012

    • Author(s)
      Andersen HR, Wohlfahrt-Veje C, Dalgard C, Christiansen L, Main KM, Nellemann C, Murata K, Jensen TK, Shakkebaek NE, Grandjean P
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2013 Final Research Report
  • [Journal Article] Changes in body burden of mercury, lead, arsenic, cadmium and selenium in infants during early lactation in comparison with placental transfer2012

    • Author(s)
      Sakamoto M, Chan HM, Domingo JL, Kubota M, Murata K
    • Journal Title

      Ecotoxicol Environ Saf

      Volume: 84 Pages: 179-184

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mercury and docosahexaenoic acid levels in maternal and cord blood in relation to segmental maternal hair mercury concentrations at parturition2012

    • Author(s)
      Sakamoto M, Chan HM, Domingo JL, Kawakami S, Murata K
    • Journal Title

      Environ Int

      Volume: 44 Pages: 112-117

    • Related Report
      2013 Final Research Report
  • [Journal Article] Effects of sleep disturbances during pregnancy on cardiac autonomic modulation in the resting state2012

    • Author(s)
      Shiga K, Murata K, Kodama H
    • Journal Title

      Int J Gynaecol Obstet

      Volume: 119 Pages: 149-153

    • Related Report
      2013 Final Research Report
  • [Journal Article] Suicide mortality for young, middle- age and elderly persons in the period of Japanese economic transition, 1975-20052012

    • Author(s)
      Fukuoka A, Iwasaki Y, Wood DC, Iwata T, Murata K
    • Journal Title

      Akita J Med

      Volume: 39 Pages: 33-44

    • NAID

      110009575389

    • Related Report
      2013 Final Research Report
  • [Journal Article] 被災地公務員の心的負担2011

    • Author(s)
      村田勝敬
    • Journal Title

      産衛誌

      Volume: 53

    • NAID

      10029139594

    • Related Report
      2013 Final Research Report
  • [Presentation] 胎児期曝露指標としての臍帯組織と胎盤の元素濃度2013

    • Author(s)
      坂本峰至, 安武章, 村田勝敬
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢市
    • Related Report
      2013 Final Research Report
  • [Presentation] メチル水銀曝露が生後18ヶ月児の発達に及ぼす影響-沿岸都市を対象に2013

    • Author(s)
      龍田希, 仲井邦彦, 村田勝敬, 岩井美幸, 柳沼梢, 黒川修行, 阿部和真, 佐藤洋
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢市
    • Related Report
      2013 Final Research Report
  • [Presentation] 農家女性における体内貯蔵鉄に対する年齢・閉経・カドミウム曝露・腎機能の複合影響2013

    • Author(s)
      堀口兵剛, 小熊悦子, 村田勝敬, 細井陽子, 香山不二雄, 大久保公美, 村上健太郎, 佐々木敏, 宮本佳代子
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢市
    • Related Report
      2013 Final Research Report
  • [Presentation] 日本の職域集団における尿中ピレスロイド系殺虫剤代謝物量の特徴2013

    • Author(s)
      杉浦友香, 上山純, 斉藤勲, 野村洸司, 近藤高明, 五藤雅博, 岩田豊人, 村田勝敬, 涌澤伸哉, 上島通弘
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢市
    • Related Report
      2013 Final Research Report
  • [Presentation] 販売従事者における食行動と血清脂質の関係2013

    • Author(s)
      荒井香織, 岩田豊人, 堀口兵剛, 村田勝敬
    • Organizer
      第72回日本産業衛生学会東北地方会
    • Place of Presentation
      盛岡市
    • Related Report
      2013 Final Research Report
  • [Presentation] 販売従事者における食行動と肝障害の関係2013

    • Author(s)
      岩田豊人, 荒井香織, 齋藤憲光, 村田勝敬
    • Organizer
      第72回日本産業衛生学会東北地方会
    • Place of Presentation
      盛岡市
    • Related Report
      2013 Final Research Report
  • [Presentation] Age-dependent threshold of urinary cadmium for renal dysfunction in Japanese farmers2012

    • Author(s)
      Horiguchi H, Oguma E, Murata K
    • Organizer
      The 48th Congress of the European Scieties of Toxicology (EUROTOX)
    • Place of Presentation
      Stockholm (Sweden)
    • Related Report
      2013 Final Research Report
  • [Presentation] 自家産米摂取によるカドミウム曝露を受けた日本の農家女性の追跡研究2012

    • Author(s)
      堀口兵剛, 村田勝敬, 小熊悦子, 細井陽子, 香山不二雄, 大久保公美, 村上健太郎, 佐々木敏, 宮本佳代子
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都市
    • Related Report
      2013 Final Research Report
  • [Presentation] メチル水銀の毛髪/血液濃度比および生物学的半減期-メチル水銀曝露実験からの検討2012

    • Author(s)
      柳沼梢, 村田勝敬, 岩井美幸, 仲井邦彦, 龍田希, 黒川修行, 佐藤洋
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都市
    • Related Report
      2013 Final Research Report
  • [Presentation] 妊娠期の母親血、臍帯血のメチル水銀、DHAと毛髪断片水銀における関連2012

    • Author(s)
      坂本峰至, 村田勝敬
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都市
    • Related Report
      2013 Final Research Report
  • [Presentation] 胎児性水俣病患者の神経運動機能の特徴2012

    • Author(s)
      岩田豊人, 高岡滋, 坂本峰至, 劉暁潔, 中村政明, 嶽石美和子, 村田勝敬
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都市
    • Related Report
      2013 Final Research Report
  • [Presentation] 環境由来化学物質の胎児期曝露と出生児の発達との関連性-生後42ヶ月時の発達2012

    • Author(s)
      龍田希, 仲井邦彦, 岩井美幸, 黒川修行, 柳沼梢, 阿部和真, 奈良隆寛, 村田勝敬, 細川徹, 佐藤洋
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都市
    • Related Report
      2013 Final Research Report
  • [Presentation] 臍帯血中のポリ塩化ビフェニル濃度に影響する要因2012

    • Author(s)
      阿部和真, 仲井邦彦, 龍田希, 岩井美幸, 黒川修行, 柳沼梢, 村田勝敬, 佐藤洋
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都市
    • Related Report
      2013 Final Research Report
  • [Presentation] 経済移行期(1973-2007)の日本人青年、中年および高齢者の自殺2012

    • Author(s)
      福岡敦子, 岩田豊人, 堀口兵剛, 村田勝敬
    • Organizer
      第61回東北公衆衛生学会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Final Research Report
  • [Presentation] The association of prental exposure to methylmercury with infant development in Tohoku Study of Child Developmen2011

    • Author(s)
      Tatsuta N, Nakai K, Murata K, Shimada M, Yaginuma-Sakurai K, Suzuki K, Kurokawa N, Hosokawa T, Satoh H
    • Organizer
      The 10th International Conference on Mercury as a Global Pollutant
    • Place of Presentation
      Nova Scotia (Canada)
    • Related Report
      2013 Final Research Report
  • [Presentation] Retrospective study on temporal and regional variations of methyl- mercury concentrations in preserved umbilical cords collected from inhabitants of the Minamata area, Japan2011

    • Author(s)
      Sakamoto M, Murata K, Akagi H
    • Organizer
      The 10th International Conference on Mercury as a Global Pollutant
    • Place of Presentation
      Nova Scotia (Canada)
    • Related Report
      2013 Final Research Report
  • [Presentation] Variation of hair to blood ratio of mercury from intervention study of methylmercury2011

    • Author(s)
      Yaginuma-Sakurai K, Iwai-Shimada M, Nakai K, Kurokawa N, Tatsuta N, Murata K, Satoh H
    • Organizer
      The 10th International Conference on Mercury as a Global Pollutant
    • Place of Presentation
      Nova Scotia (Canada)
    • Related Report
      2013 Final Research Report
  • [Presentation] 秋田県の農家における自家産米摂取によるカドミウム経口曝露の実態とそれに対する保健対策2011

    • Author(s)
      堀口兵剛, 小熊悦子, 細井陽子, 香山不二雄, 大久保公美, 村上健太郎, 佐々木敏, 宮本佳代子, 村田勝敬
    • Organizer
      第60回東北公衆衛生学会
    • Place of Presentation
      福島市
    • Related Report
      2013 Final Research Report
  • [Presentation] 販売従事者における食行動と血清脂質の関係

    • Author(s)
      荒井香織、岩田豊人、堀口兵剛、村田勝敬
    • Organizer
      第72回日本産業衛生学会東北地方会
    • Place of Presentation
      岩手県盛岡市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 販売従事者における食行動と肝障害の関係

    • Author(s)
      岩田豊人、荒井香織、齋藤憲光、村田勝敬
    • Organizer
      第72回日本産業衛生学会東北地方会
    • Place of Presentation
      岩手県盛岡市
    • Related Report
      2013 Annual Research Report
  • [Book] 低濃度メチル水銀の神経発達影響に関する調査-フェロー諸島とセイシェル. In :毒性の科学-分子・細胞から人間集団まで2014

    • Author(s)
      村田勝敬 (熊谷嘉人,姫野誠一郎,渡辺知保(編))
    • Publisher
      東京大学出版会
    • Related Report
      2013 Final Research Report
  • [Book] Minamata disease. In : Reference Module in Earth Systems and Environmental Sciences2013

    • Author(s)
      Murata K, Sakamoto M
    • Publisher
      Elsevier
    • Related Report
      2013 Final Research Report
  • [Remarks] 研究成果 Publication

    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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