Epidemiologic study on the origin of lifestyle-related disease: the combined effect of intrauterine environment and lifestyle after birth.

• Project/Area Number: 23590787
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Nagoya University
• Principal Investigator: TAMAKOSHI Koji 名古屋大学, 医学(系)研究科(研究院), 教授 (30262900)
• Co-Investigator(Renkei-kenkyūsha): YATSUYA Hiroshi 藤田保健衛生大学, 医学部, 教授 (30324437)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 生活習慣病 / 糖尿病 / 出生時体重 / 喫煙 / 母子保健

Outline of Final Research Achievements

We conducted the epidemiologic study to elucidate the combined effect of intrauterine environment and lifestyle after birth on the development of lifestyle-related disease. Birth weight was used as an index of intrauterine environment. In this study, the combined effect of birth weight and smoking behavior on the development of type 2 diabetes was examined. The subjects born with less than 2500g had a significant high risk of type 2 diabetes independent of smoking behavior after birth. The subjects with smoking history had a higher risk of type 2 diabetes than those with no smoking history in each birth weight group. Interestingly the subjects who were born with 3500g and over and had smoking history presented a similar high risk of type 2 diabetes to those born with less than 2500g.

Research Products

• [Journal Article] Smoking and Diabetes: Is the Association Mediated by Adiponectin, Leptin, or C-reactive Protein? (2015)
  • Author(s): Hilawe EH, Yatsuya H, Li Y, Uemura M, Wang C, Chiang C, Toyoshima H, Tamakoshi K, Zhang Y, Kawazoe N, Aoyama A.
  • Journal Title: Journal of Epidemiology Volume: 25 Issue: 2 Pages: 99-109
  • DOI: 10.2188/jea.JE20140055
  • NAID: 130004704584
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Open Access
• [Journal Article] Body mass index-modified relationship of chronic mental stress with resting blood pressure during 5 years in Japanese middle-aged male workers. (2014)
  • Author(s): Toyoshima H, Otsuka R, Hashimoto S, Tamakoshi K, Yatsuya H.
  • Journal Title: Circ J Volume: 78 Pages: 1379-1386
  • NAID: 130003391123
  • Peer Reviewed
• [Journal Article] Descriptive epidemiological study of food intake among Japanese adults: analyses by age, time and birth cohort model. (2014)
  • Author(s): Otsuka R, Yatsuya H, Tamakoshi K.
  • Journal Title: BMC Public Health Volume: 14 Issue: 1 Pages: 328-328
  • DOI: 10.1186/1471-2458-14-328
  • Peer Reviewed
• [Journal Article] Positive association between high sensitivity C-reactive protein and incidence of type-2 diabetes mellitus in Japanese workers : 6-year follow-up (2013)
  • Author(s): Wang C, Yatsuya H, Tamakoshi K, Uemura M, Li Y, Wada K, Yamashita K, Kawaguchi L, Toyoshima H, Aoyama A
  • Journal Title: Diabetes Metab Res Rev Volume: 29 Issue: 5 Pages: 398-405
  • DOI: 10.1002/dmrr.2406
  • Peer Reviewed
• [Journal Article] Associations of protein, fat, and carbohydrate intakes with insomnia symptoms among middle-aged Japanese workers. (2013)
  • Author(s): Tanaka E, Yatsuya H, Uemura M, Murata C, Otsuka R, Toyoshima H, Tamakoshi K, Sasaki S, Kawaguchi L, Aoyama A.
  • Journal Title: J Epidemiol. Volume: 23 Pages: 132-138
  • NAID: 10031155714
  • Peer Reviewed
• [Presentation] 朝食の摂取頻度と9年間の2型糖尿病発症との関連 (2013)
  • Author(s): 上村 真由, 八谷 寛, 李 媛英, 王 超辰, 江 啓発, 大塚 礼, 佐々木 敏, 豊嶋 英明, 玉腰 浩司, 青山 温子
  • Organizer: 第49回日本循環器病予防学会・日本循環器管理研究協議会総会
  • Place of Presentation: 金沢市文化ホール
• [Presentation] 日本人勤労者における高感度CRPと10年間の高血圧発症との関連 (2013)
  • Author(s): 上村真由，八谷寛，玉腰浩司，王超辰，豊嶋英明，川口レオ，江啓発，李媛英，青山温子
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪大学体育館（大阪）
• [Presentation] 肥満度およびメタボリックシンドローム構成要素数と9年間の2型糖尿病発症の関連 (2012)
  • Author(s): 上村真由，八谷寛，李媛英，大塚礼，和田恵子，豊嶋英明，玉腰浩司，青山温子
  • Organizer: 第71回日本公衆衛生学会総会
  • Place of Presentation: サンルート国際ホテル山口（山口）
• [Presentation] Association between CRP and Incidence of Type-2 Diabetes in a Japanese Worksite-based Cohort (2012)
  • Author(s): 王超辰，八谷寛，玉腰浩司，豊嶋英明，李媛英，山下健太郎，上村真由，青山温子
  • Organizer: 第22回日本疫学会
  • Place of Presentation: 学術総合センター（東京）
• [Presentation] 米国心臓学会が提唱する食事・栄養摂取指標と6年間の糖尿病発症との関連 (2012)
  • Author(s): 上村真由，八谷寛，玉腰浩司，豊嶋英明，大塚礼，李媛英，佐々木敏，青山温子
  • Organizer: 第22回日本疫学会
  • Place of Presentation: 学術総合センター（東京）
• [Presentation] アメリカ心臓協会の理想的な栄養摂取指標を用いた我が国中年男女の食生活の現状分析
  • Author(s): 上村 真由, 八谷 寛, 玉腰 浩司, 豊嶋 英明, 大塚 礼, 青山 温子
  • Organizer: 第57回東海公衆衛生学会学術大会
  • Place of Presentation: 掛川市徳育保健センター