| Budget Amount *help |
¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Outline of Final Research Achievements |
Subjects aged 60-79 were examined with physical examinations, life-style questionnaires, laboratory assessment, Intima-media thicness (IMT) and coronary calcium score(CCS) using standardized methods. Plasma samples were stored at -80°C, and concentration of ADMA was determined using a validated high-throughput liquid chromatographic tandem mass spectrometric assay. The average concentrations and standard deviation (SD) of plasma ADMA were 0.43 ± 0.06μmol/L. Higher level of ADMA was significantly and positively associated with proportion of current smoking. It was also significantly and positively associated with eGFR. In full adjusted linear regression models, ADMA was non-significantly associated with IMT and CCS.
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