Relationship of plasma asymmetrical dimethylarginine to coronary artery calcification in elderly population

Research Project

Project/Area Number	23590792
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Public health/Health science
Research Institution	Kanazawa Medical University
Principal Investigator	NAGASAWA Shin-ya 金沢医科大学, 医学部, 助教 (30510341)
Co-Investigator(Kenkyū-buntansha)	MIURA Katsuyuki 滋賀医科大学, 医学部, 教授 (90257452)
Project Period (FY)	2011-04-28 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000) Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000) Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000) Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000) Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Keywords	成人保健 / 心腎連関
Outline of Final Research Achievements	Subjects aged 60-79 were examined with physical examinations, life-style questionnaires, laboratory assessment, Intima-media thicness (IMT) and coronary calcium score(CCS) using standardized methods. Plasma samples were stored at -80°C, and concentration of ADMA was determined using a validated high-throughput liquid chromatographic tandem mass spectrometric assay. The average concentrations and standard deviation (SD) of plasma ADMA were 0.43 ± 0.06μmol/L. Higher level of ADMA was significantly and positively associated with proportion of current smoking. It was also significantly and positively associated with eGFR. In full adjusted linear regression models, ADMA was non-significantly associated with IMT and CCS.