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The relationships of lifestyle factors with the risk of developing gastric cancer in a general Japanese population; the Hisayama Study

Research Project

Project/Area Number 23590797
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Public health/Health science
Research InstitutionKyushu University

Principal Investigator

IKEDA Fumie  九州大学, 医学(系)研究科(研究院), 助教 (80596825)

Co-Investigator(Kenkyū-buntansha) 清原 裕  九州大学, 大学院医学研究院環境 医学分野, 教授 (80161602)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords疫学 / 胃癌 / コホート研究 / 久山町研究
Research Abstract

The aims of this study were to investigate the relationships of lifestyle factors with the risk of developing gastric cancer in a prospective study of 2,742 community-dwelling Japanese individuals aged 40 years or older. First, we investigated the relationship between white blood cell (WBC) count and the development of gastric cancer. As a result, the risk of the cancer increased significantly with higher WBC level. Next, we examined the relationship between dietary vitamin A intake and the risk of gastric cancer. The age- and sex-adjusted incidence of gastric cancer rose linearly with increasing levels of dietary vitamin A intake. Finally, we assessed whether the combination of Helicobacter (H.) pylori serology and serum pepsinogen test could be a good predictor of gastric cancer incidence. As a result, this method significantly increased the predictive ability for gastric cancer, compared with H.pylori serology alone.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (36 results)

All 2014 2013 2012 2011 Other

All Journal Article (30 results) (of which Peer Reviewed: 15 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (4 results) (of which Invited: 1 results) Remarks (2 results)

  • [Journal Article] Trends in the incidence and survival of intracerebral hemorrhage by its location in Japanese community2014

    • Author(s)
      Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Shikata K, Kamouchi M, Kitazono T, Kiyohara Y
    • Journal Title

      Circ J

      Volume: 78 Pages: 403-409

    • Related Report
      2013 Final Research Report
  • [Journal Article] Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population : the Hisayama Study2014

    • Author(s)
      Imamura T, Doi Y, Ninomiya T, Hata J, Nagata M, Ikeda F, Mukai N, Hirakawa Y, Yoshida D, Fukuhara M, Kitazono T, Kiyohara Y
    • Journal Title

      Atherosclerosis

      Volume: 233 Pages: 343-348

    • Related Report
      2013 Final Research Report
  • [Journal Article] Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects : the Hisayama Study2014

    • Author(s)
      Mukai N, Yasuda M, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y
    • Journal Title

      Cardiovac Diabetol

      Volume: 13 Pages: 45-45

    • Related Report
      2013 Final Research Report
  • [Journal Article] Trends in the Incidence and Survival of Intracerebral Hemorrhage by its Location in a Japanese Community2014

    • Author(s)
      Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Shikata K, Kamouchi M, Kitazono T, Kiyohara Y
    • Journal Title

      Circulation Journal

      Volume: 78 Issue: 2 Pages: 403-409

    • DOI

      10.1253/circj.CJ-13-0811

    • NAID

      130003382214

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: the Hisayama Study.2014

    • Author(s)
      Imamura T, Doi Y, Ninomiya T, Hata J, Nagata M, Ikeda F, Mukai N, Hirakawa Y, Yoshida D, Fukuhara M, Kitazono T, Kiyohara Y
    • Journal Title

      Atherosclerosis

      Volume: 233 Issue: 2 Pages: 343-348

    • DOI

      10.1016/j.atherosclerosis.2014.01.005

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects: the Hisayama Study.2014

    • Author(s)
      Mukai N, Yasuda M, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y.
    • Journal Title

      Cardiovasc Diabetol

      Volume: 13 Issue: 1 Pages: 45-45

    • DOI

      10.1186/1475-2840-13-45

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] White-coat and masked hypertension are associated with carotid atherosclerosis in a general population : the Hisayama Study2013

    • Author(s)
      Fukuhara M, Arima H, Ninomiya T, Hata J, Hirakawa Y, Doi Y, Yonemoto K, Mukai N, Nagata M, Ikeda F, Matsumura K, Kitazono T, Kiyohara Y
    • Journal Title

      Stroke

      Volume: 44 Pages: 1512-1517

    • Related Report
      2013 Final Research Report
  • [Journal Article] Temporal trends in sudden unexpected death in a general population : the Hisayama Study2013

    • Author(s)
      Nagata M, Ninomiya T, Doi Y, Hata J, Ikeda F, Mukai N, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y
    • Journal Title

      Am Heart J

      Volume: 165 Pages: 932-938

    • Related Report
      2013 Final Research Report
  • [Journal Article] Secular trends in cardiovascular disease and its risk factors in Japanese : half-century data from the Hisayama Study(1961-2009)2013

    • Author(s)
      Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y
    • Journal Title

      Circulation

      Volume: 128 Pages: 1198-1205

    • Related Report
      2013 Final Research Report
  • [Journal Article] Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population : the Hisayama Study2013

    • Author(s)
      Ikeda F, Doi Y, Ninomiya T, Hirakawa Y, Mukai N, Hata J, Shikata K, Yoshida D, Matsumoto T, Kitazono T, Kiyohara Y
    • Journal Title

      Cardiovasc Diabetol

      Volume: 12 Pages: 164-164

    • Related Report
      2013 Final Research Report
  • [Journal Article] White-coat and masked hypertension are associated with carotid atherosclerosis in a general population: the Hisayama Study.2013

    • Author(s)
      Fukuhara M, Arima H, Ninomiya T, Hata J, Hirakawa Y, Doi Y, Yonemoto K, Mukai N, Nagata M, Ikeda F, Matsumura K, Kitazono T, Kiyohara Y.
    • Journal Title

      Stroke

      Volume: 44 Issue: 6 Pages: 1512-1517

    • DOI

      10.1161/strokeaha.111.000704

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporal trends in sudden unexpected death in a general population: the Hisayama Study.2013

    • Author(s)
      Nagata M, Ninomiya T, Doi Y, Hata J, Ikeda F, Mukai N, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y.
    • Journal Title

      Am Heart J

      Volume: 165 Issue: 6 Pages: 932-938

    • DOI

      10.1016/j.ahj.2013.02.028

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009).2013

    • Author(s)
      Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y.
    • Journal Title

      Circulation

      Volume: 128 Issue: 11 Pages: 1198-1205

    • DOI

      10.1161/circulationaha.113.002424

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population: the Hisayama Study.2013

    • Author(s)
      Ikeda F, Doi Y, Ninomiya T, Hirakawa Y, Mukai N, Hata J, Shikata K, Yoshida D, Matsumoto T, Kitazono T, Kiyohara Y.
    • Journal Title

      Cardiovasc Diabetol

      Volume: 12 Issue: 1 Pages: 164-164

    • DOI

      10.1186/1475-2840-12-164

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] White blood cell count and risk of gastric cancer incidence in a general Japanese population : the Hisayama Study2012

    • Author(s)
      Iida M, Ikeda F, Ninomiya T, Yonemoto K, Doi Y, Hata J, Matsumoto T, Iida M, Kiyohara Y
    • Journal Title

      Am J Epidemiol

      Volume: 175 Pages: 504-510

    • Related Report
      2013 Final Research Report
  • [Journal Article] Dietary vitamin A intake and incidence of gastric cancer in a general Japanese population : the Hisayama Study2012

    • Author(s)
      Miyazaki M, Doi Y, Ikeda F, Ninomiya T, Hata J, Uchida K, Shirota T, Matsumoto T, Iida M, Kiyohara Y
    • Journal Title

      Gastric Cancer

      Volume: 15 Pages: 162-169

    • NAID

      40019230986

    • Related Report
      2013 Final Research Report
  • [Journal Article] Optimal cutoff value of the serum pepsinogen level for prediction of gastric cancer incidence : the Hisayama Study2012

    • Author(s)
      Shikata K, Ninomiya T, Yonemoto K, Ikeda F, Hata J, Doi Y, Fukuhara M, Matsumoto T, Iida M, Kitazono T, Kiyohara Y
    • Journal Title

      Scand J Gastroenterol

      Volume: 47 Pages: 669-675

    • Related Report
      2013 Final Research Report
  • [Journal Article] Smoking cessation improves mortality in Japanese men : the Hisayama Study2012

    • Author(s)
      Ikeda F, Ninomiya T, Doi Y, Hata J, Fukuhara M, Matsumoto T, Kiyohara Y
    • Journal Title

      Tob control

      Volume: 21 Pages: 416-421

    • Related Report
      2013 Final Research Report
  • [Journal Article] Prevalence and causes of functional disability in an elderly general population of Japanese : the Hisayama Study2012

    • Author(s)
      Yoshida D, Ninomiya T, Doi Y, Hata J, Fukuhara M, Ikeda F, Mukai N, Kiyohara Y
    • Journal Title

      J Epidemiol

      Volume: 22 Pages: 222-229

    • NAID

      10030618141

    • Related Report
      2013 Final Research Report
  • [Journal Article] Dietary vitamin A intake and incidence of gastric cancer in a general Japanese population : the Hisayama Study2012

    • Author(s)
      Miyazaki M, Doi Y, Ikeda F, Ninomiya T, Hata J, Uchida K, Shirota T, Matsumoto T, Iida M, Kiyohara Y
    • Journal Title

      Gastric Cancer

      Volume: 15(2) Issue: 2 Pages: 162-169

    • DOI

      10.1007/s10120-011-0092-7

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optimal cutoff value of the serum pepsinogen level for prediction of gastric cancer incidence : the Hisayama Study2012

    • Author(s)
      Shikata K., Ninomiya T., Yonemoto K., 他8名
    • Journal Title

      Scandinavian Journal of Gastroenterology

      Volume: 47(6) Issue: 6 Pages: 669-675

    • DOI

      10.3109/00365521.2012.658855

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Smoking cessation improves mortality in Japanese men: the Hisayama Study.2012

    • Author(s)
      Ikeda F (1番目), et al.
    • Journal Title

      Tob Control

      Volume: 21 Issue: 4 Pages: 416-421

    • DOI

      10.1136/tc.2010.039362

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevalence and Causes of Functional Disability in an Elderly General Population of Japanese: The Hisayama Study2012

    • Author(s)
      Yoshida D, Fukuhara M(5番目), Kiyohara Y(最後), 他5名
    • Journal Title

      Journal of Epidemiology

      Volume: 22 Issue: 3 Pages: 222-229

    • DOI

      10.2188/jea.JE20110083

    • NAID

      10030618141

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Body mass index and stroke incidence in a Japanese community : the Hisayama Study2011

    • Author(s)
      Yonemoto K, Doi Y, Hata J, Ninomiya T, Fukuhara M, Ikeda F, Mukai N Iida M, Kiyohara Y
    • Journal Title

      Hypertens Res

      Volume: 34 Pages: 274-279

    • NAID

      10031163165

    • Related Report
      2013 Final Research Report
  • [Journal Article] Combined effects of smoking and hypercholesterolemia on the stroke and coronary heart disease in Japanese : the Hisayama Study2011

    • Author(s)
      Hata J, Doi Y, Ninomiya T, Fukuhara M, Ikeda F, Mukai N, Hirakawa Y, Kitazono T, Kiyohara Y
    • Journal Title

      Cerebrovasc Dis

      Volume: 31 Pages: 477-484

    • Related Report
      2013 Final Research Report
  • [Journal Article] N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in a Japanese community : the Hisayama Study2011

    • Author(s)
      Doi Y, Ninomiya T, Hata J, Hirakawa Y, Mukai N, Ikeda F, Fukuhara M, Iwase M, Kiyohara Y
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 31 Pages: 2997-3003

    • Related Report
      2013 Final Research Report
  • [Journal Article] Body mass index and stroke incidence in a Japanese community2011

    • Author(s)
      Yonemoto K, Fukuhara M(5番目), Kiyohara Y(最後), 他6名
    • Journal Title

      the Hisayama Study

      Volume: 34 Issue: 2 Pages: 274-279

    • DOI

      10.1038/hr.2010.220

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combined effects of smoking and hypercholesterolemia on the risk of stroke and coronary heart disease in Japanese2011

    • Author(s)
      Hata J, Fukuhara M(4番目), Kiyohara Y(最後), 他6名
    • Journal Title

      the Hisayama Study

      Volume: 31 Issue: 5 Pages: 477-484

    • DOI

      10.1159/000324392

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in a Japanese community2011

    • Author(s)
      Doi Y, Fukuhara M(7番目), Kiyohara Y(最後), 他6名
    • Journal Title

      the Hisayama Study

      Volume: 31 Issue: 12 Pages: 2997-3003

    • DOI

      10.1161/atvbaha.111.223669

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] White blood cell count and risk of gastric cancer incidence in a general Japanese population : the Hisayama Study2011

    • Author(s)
      Iida, M., et.al.
    • Journal Title

      Am J Epidemiol

      Volume: 175(6) Issue: 6 Pages: 504-10

    • DOI

      10.1093/aje/kwr345

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 胃癌の疫学調査・久山町研究~H.pylori感染・糖尿病と胃癌の関係を中心に~2013

    • Author(s)
      池田文恵
    • Organizer
      第51回日本消化器がん検診学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-10-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 日本人における胃癌発症予測モデルの作成:久山町研究2011

    • Author(s)
      飯田真大, 池田文恵, 志方健太郎, 二宮利治, 松本主之, 清原裕
    • Organizer
      第53回日本消化器病学会大会
    • Place of Presentation
      福岡市
    • Year and Date
      2011-10-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 日本人における胃癌発症予測モデルの作成:久山町研究2011

    • Author(s)
      飯田真大、池田文恵(2番目)ら
    • Organizer
      第53回日本消化器病学会大会
    • Place of Presentation
      福岡市
    • Related Report
      2011 Research-status Report
  • [Presentation] 胃癌の疫学調査・久山町研究~H.pylori感染・糖尿病と胃癌の関係を中心に~

    • Author(s)
      池田文恵
    • Organizer
      JDDW 2013 Tokyo (日本消化器癌検診学会)
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Remarks] 九州大学大学院 医学研究院 環境医学分野ホームページ

    • URL

      http://www.envmed.med.kyushu-u.ac.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.envmed.med.kyushu-u.ac.jp/

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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