The relationships of lifestyle factors with the risk of developing gastric cancer in a general Japanese population; the Hisayama Study

• Project/Area Number: 23590797
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Kyushu University
• Principal Investigator: IKEDA Fumie 九州大学, 医学(系)研究科(研究院), 助教 (80596825)
• Co-Investigator(Kenkyū-buntansha): 清原 裕 九州大学, 大学院医学研究院環境 医学分野, 教授 (80161602)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 疫学 / 胃癌 / コホート研究 / 久山町研究

Research Abstract

The aims of this study were to investigate the relationships of lifestyle factors with the risk of developing gastric cancer in a prospective study of 2,742 community-dwelling Japanese individuals aged 40 years or older. First, we investigated the relationship between white blood cell (WBC) count and the development of gastric cancer. As a result, the risk of the cancer increased significantly with higher WBC level. Next, we examined the relationship between dietary vitamin A intake and the risk of gastric cancer. The age- and sex-adjusted incidence of gastric cancer rose linearly with increasing levels of dietary vitamin A intake. Finally, we assessed whether the combination of Helicobacter (H.) pylori serology and serum pepsinogen test could be a good predictor of gastric cancer incidence. As a result, this method significantly increased the predictive ability for gastric cancer, compared with H.pylori serology alone.

Research Products

• [Journal Article] Trends in the incidence and survival of intracerebral hemorrhage by its location in Japanese community (2014)
  • Author(s): Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Shikata K, Kamouchi M, Kitazono T, Kiyohara Y
  • Journal Title: Circ J Volume: 78 Pages: 403-409
• [Journal Article] Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population : the Hisayama Study (2014)
  • Author(s): Imamura T, Doi Y, Ninomiya T, Hata J, Nagata M, Ikeda F, Mukai N, Hirakawa Y, Yoshida D, Fukuhara M, Kitazono T, Kiyohara Y
  • Journal Title: Atherosclerosis Volume: 233 Pages: 343-348
• [Journal Article] Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects : the Hisayama Study (2014)
  • Author(s): Mukai N, Yasuda M, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y
  • Journal Title: Cardiovac Diabetol Volume: 13 Pages: 45-45
• [Journal Article] Trends in the Incidence and Survival of Intracerebral Hemorrhage by its Location in a Japanese Community (2014)
  • Author(s): Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Shikata K, Kamouchi M, Kitazono T, Kiyohara Y
  • Journal Title: Circulation Journal Volume: 78 Issue: 2 Pages: 403-409
  • DOI: 10.1253/circj.CJ-13-0811
  • NAID: 130003382214
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: the Hisayama Study. (2014)
  • Author(s): Imamura T, Doi Y, Ninomiya T, Hata J, Nagata M, Ikeda F, Mukai N, Hirakawa Y, Yoshida D, Fukuhara M, Kitazono T, Kiyohara Y
  • Journal Title: Atherosclerosis Volume: 233 Issue: 2 Pages: 343-348
  • DOI: 10.1016/j.atherosclerosis.2014.01.005
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects: the Hisayama Study. (2014)
  • Author(s): Mukai N, Yasuda M, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y.
  • Journal Title: Cardiovasc Diabetol Volume: 13 Issue: 1 Pages: 45-45
  • DOI: 10.1186/1475-2840-13-45
  • Peer Reviewed / Open Access
• [Journal Article] White-coat and masked hypertension are associated with carotid atherosclerosis in a general population : the Hisayama Study (2013)
  • Author(s): Fukuhara M, Arima H, Ninomiya T, Hata J, Hirakawa Y, Doi Y, Yonemoto K, Mukai N, Nagata M, Ikeda F, Matsumura K, Kitazono T, Kiyohara Y
  • Journal Title: Stroke Volume: 44 Pages: 1512-1517
• [Journal Article] Temporal trends in sudden unexpected death in a general population : the Hisayama Study (2013)
  • Author(s): Nagata M, Ninomiya T, Doi Y, Hata J, Ikeda F, Mukai N, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y
  • Journal Title: Am Heart J Volume: 165 Pages: 932-938
• [Journal Article] Secular trends in cardiovascular disease and its risk factors in Japanese : half-century data from the Hisayama Study(1961-2009) (2013)
  • Author(s): Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y
  • Journal Title: Circulation Volume: 128 Pages: 1198-1205
• [Journal Article] Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population : the Hisayama Study (2013)
  • Author(s): Ikeda F, Doi Y, Ninomiya T, Hirakawa Y, Mukai N, Hata J, Shikata K, Yoshida D, Matsumoto T, Kitazono T, Kiyohara Y
  • Journal Title: Cardiovasc Diabetol Volume: 12 Pages: 164-164
• [Journal Article] White-coat and masked hypertension are associated with carotid atherosclerosis in a general population: the Hisayama Study. (2013)
  • Author(s): Fukuhara M, Arima H, Ninomiya T, Hata J, Hirakawa Y, Doi Y, Yonemoto K, Mukai N, Nagata M, Ikeda F, Matsumura K, Kitazono T, Kiyohara Y.
  • Journal Title: Stroke Volume: 44 Issue: 6 Pages: 1512-1517
  • DOI: 10.1161/strokeaha.111.000704
  • Peer Reviewed
• [Journal Article] Temporal trends in sudden unexpected death in a general population: the Hisayama Study. (2013)
  • Author(s): Nagata M, Ninomiya T, Doi Y, Hata J, Ikeda F, Mukai N, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y.
  • Journal Title: Am Heart J Volume: 165 Issue: 6 Pages: 932-938
  • DOI: 10.1016/j.ahj.2013.02.028
  • Peer Reviewed
• [Journal Article] Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009). (2013)
  • Author(s): Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y.
  • Journal Title: Circulation Volume: 128 Issue: 11 Pages: 1198-1205
  • DOI: 10.1161/circulationaha.113.002424
  • Peer Reviewed
• [Journal Article] Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population: the Hisayama Study. (2013)
  • Author(s): Ikeda F, Doi Y, Ninomiya T, Hirakawa Y, Mukai N, Hata J, Shikata K, Yoshida D, Matsumoto T, Kitazono T, Kiyohara Y.
  • Journal Title: Cardiovasc Diabetol Volume: 12 Issue: 1 Pages: 164-164
  • DOI: 10.1186/1475-2840-12-164
  • Peer Reviewed
• [Journal Article] White blood cell count and risk of gastric cancer incidence in a general Japanese population : the Hisayama Study (2012)
  • Author(s): Iida M, Ikeda F, Ninomiya T, Yonemoto K, Doi Y, Hata J, Matsumoto T, Iida M, Kiyohara Y
  • Journal Title: Am J Epidemiol Volume: 175 Pages: 504-510
• [Journal Article] Dietary vitamin A intake and incidence of gastric cancer in a general Japanese population : the Hisayama Study (2012)
  • Author(s): Miyazaki M, Doi Y, Ikeda F, Ninomiya T, Hata J, Uchida K, Shirota T, Matsumoto T, Iida M, Kiyohara Y
  • Journal Title: Gastric Cancer Volume: 15 Pages: 162-169
  • NAID: 40019230986
• [Journal Article] Optimal cutoff value of the serum pepsinogen level for prediction of gastric cancer incidence : the Hisayama Study (2012)
  • Author(s): Shikata K, Ninomiya T, Yonemoto K, Ikeda F, Hata J, Doi Y, Fukuhara M, Matsumoto T, Iida M, Kitazono T, Kiyohara Y
  • Journal Title: Scand J Gastroenterol Volume: 47 Pages: 669-675
• [Journal Article] Smoking cessation improves mortality in Japanese men : the Hisayama Study (2012)
  • Author(s): Ikeda F, Ninomiya T, Doi Y, Hata J, Fukuhara M, Matsumoto T, Kiyohara Y
  • Journal Title: Tob control Volume: 21 Pages: 416-421
• [Journal Article] Prevalence and causes of functional disability in an elderly general population of Japanese : the Hisayama Study (2012)
  • Author(s): Yoshida D, Ninomiya T, Doi Y, Hata J, Fukuhara M, Ikeda F, Mukai N, Kiyohara Y
  • Journal Title: J Epidemiol Volume: 22 Pages: 222-229
  • NAID: 10030618141
• [Journal Article] Dietary vitamin A intake and incidence of gastric cancer in a general Japanese population : the Hisayama Study (2012)
  • Author(s): Miyazaki M, Doi Y, Ikeda F, Ninomiya T, Hata J, Uchida K, Shirota T, Matsumoto T, Iida M, Kiyohara Y
  • Journal Title: Gastric Cancer Volume: 15(2) Issue: 2 Pages: 162-169
  • DOI: 10.1007/s10120-011-0092-7
  • Peer Reviewed
• [Journal Article] Optimal cutoff value of the serum pepsinogen level for prediction of gastric cancer incidence : the Hisayama Study (2012)
  • Author(s): Shikata K., Ninomiya T., Yonemoto K., 他8名
  • Journal Title: Scandinavian Journal of Gastroenterology Volume: 47(6) Issue: 6 Pages: 669-675
  • DOI: 10.3109/00365521.2012.658855
  • Peer Reviewed
• [Journal Article] Smoking cessation improves mortality in Japanese men: the Hisayama Study. (2012)
  • Author(s): Ikeda F (1番目）, et al.
  • Journal Title: Tob Control Volume: 21 Issue: 4 Pages: 416-421
  • DOI: 10.1136/tc.2010.039362
  • Peer Reviewed
• [Journal Article] Prevalence and Causes of Functional Disability in an Elderly General Population of Japanese: The Hisayama Study (2012)
  • Author(s): Yoshida D, Fukuhara M(5番目), Kiyohara Y(最後), 他5名
  • Journal Title: Journal of Epidemiology Volume: 22 Issue: 3 Pages: 222-229
  • DOI: 10.2188/jea.JE20110083
  • NAID: 10030618141
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed
• [Journal Article] Body mass index and stroke incidence in a Japanese community : the Hisayama Study (2011)
  • Author(s): Yonemoto K, Doi Y, Hata J, Ninomiya T, Fukuhara M, Ikeda F, Mukai N Iida M, Kiyohara Y
  • Journal Title: Hypertens Res Volume: 34 Pages: 274-279
  • NAID: 10031163165
• [Journal Article] Combined effects of smoking and hypercholesterolemia on the stroke and coronary heart disease in Japanese : the Hisayama Study (2011)
  • Author(s): Hata J, Doi Y, Ninomiya T, Fukuhara M, Ikeda F, Mukai N, Hirakawa Y, Kitazono T, Kiyohara Y
  • Journal Title: Cerebrovasc Dis Volume: 31 Pages: 477-484
• [Journal Article] N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in a Japanese community : the Hisayama Study (2011)
  • Author(s): Doi Y, Ninomiya T, Hata J, Hirakawa Y, Mukai N, Ikeda F, Fukuhara M, Iwase M, Kiyohara Y
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 31 Pages: 2997-3003
• [Journal Article] Body mass index and stroke incidence in a Japanese community (2011)
  • Author(s): Yonemoto K, Fukuhara M(5番目), Kiyohara Y(最後), 他6名
  • Journal Title: the Hisayama Study Volume: 34 Issue: 2 Pages: 274-279
  • DOI: 10.1038/hr.2010.220
  • Peer Reviewed
• [Journal Article] Combined effects of smoking and hypercholesterolemia on the risk of stroke and coronary heart disease in Japanese (2011)
  • Author(s): Hata J, Fukuhara M(4番目), Kiyohara Y(最後), 他6名
  • Journal Title: the Hisayama Study Volume: 31 Issue: 5 Pages: 477-484
  • DOI: 10.1159/000324392
  • Peer Reviewed
• [Journal Article] N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in a Japanese community (2011)
  • Author(s): Doi Y, Fukuhara M(7番目), Kiyohara Y(最後), 他6名
  • Journal Title: the Hisayama Study Volume: 31 Issue: 12 Pages: 2997-3003
  • DOI: 10.1161/atvbaha.111.223669
  • Peer Reviewed
• [Journal Article] White blood cell count and risk of gastric cancer incidence in a general Japanese population : the Hisayama Study (2011)
  • Author(s): Iida, M., et.al.
  • Journal Title: Am J Epidemiol Volume: 175(6) Issue: 6 Pages: 504-10
  • DOI: 10.1093/aje/kwr345
  • Peer Reviewed
• [Presentation] 胃癌の疫学調査・久山町研究～H.pylori感染・糖尿病と胃癌の関係を中心に～ (2013)
  • Author(s): 池田文恵
  • Organizer: 第51回日本消化器がん検診学会大会
  • Place of Presentation: 東京
  • Year and Date: 2013-10-09
• [Presentation] 日本人における胃癌発症予測モデルの作成:久山町研究 (2011)
  • Author(s): 飯田真大, 池田文恵, 志方健太郎, 二宮利治, 松本主之, 清原裕
  • Organizer: 第53回日本消化器病学会大会
  • Place of Presentation: 福岡市
  • Year and Date: 2011-10-20
• [Presentation] 日本人における胃癌発症予測モデルの作成：久山町研究 (2011)
  • Author(s): 飯田真大、池田文恵（2番目）ら
  • Organizer: 第53回日本消化器病学会大会
  • Place of Presentation: 福岡市
• [Presentation] 胃癌の疫学調査・久山町研究～H.pylori感染・糖尿病と胃癌の関係を中心に～
  • Author(s): 池田文恵
  • Organizer: JDDW 2013 Tokyo (日本消化器癌検診学会）
  • Place of Presentation: 東京
  • Invited
• [Remarks] 九州大学大学院 医学研究院 環境医学分野ホームページ
  • URL: http://www.envmed.med.kyushu-u.ac.jp/
• [Remarks]
  • URL: http://www.envmed.med.kyushu-u.ac.jp/