Impact of cardiovascular risk factors on medical expenditures: the Iwate KENCO study

• Project/Area Number: 23590810
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Iwate Medical University
• Principal Investigator: TANNO KOZO 岩手医科大学, 医学部, 准教授 (20327026)
• Co-Investigator(Renkei-kenkyūsha): OHSAWA Masaki 岩手医科大学, 医学部, 講師 (60295970) ; ONODA Toshiyuki 岩手医科大学, 医学部, 准教授 (00254748) ; SAKATA Kiyomi 岩手医科大学, 医学部, 教授 (50225794) ; ITAI Kazuyoshi 公益財団法人結核予防会, 第一健康相談 所, 上級研究員 (10048572) ; OKAYAMA Akira 公益財団法人結核予防会, 第一健康相談 所, 所長 (60169159)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 社会医学 / 循環器・高血圧 / コホート / 医療費

Research Abstract

We evaluated the relationship between cardiovascular risk factors (obesity, hypertension, diabetes, dyslipidemia, smoking, and chronic kidney disease (CKD)) and medical expenditures using data of 10899 Japanese National Health Insurance beneficiaries aged less than 75 years (mean, 58.7 years). Mean medical expenditure was higher in participants who had cardiovascular risk factors than those had no risk factor. In this cohort, 12.9% and 6.4% of total medical expenditures were attributable to participants who had hypertension and CKD, respectively.

Research Products

• [Journal Article] Associations of number of teeth with risks for all-cause mortality and cause-specific mortality in middle-aged and elderly men in the northern part of Japan: the Iwate-KENCO study. (2014)
  • Author(s): Ando A, Tanno K, Ohsawa M, Onoda T, Sakata K, Tanaka F, Makita S, Nakamura M, Omama S, Ogasawara K, Ishibashi Y, Kuribayashi T, Koyama T, Itai K, Ogawa A, and Okayama A.
  • Journal Title: Community Dent Oral Epidemiol Volume: 印刷中 Issue: 4 Pages: 358-65
  • DOI: 10.1111/cdoe.12095
  • Peer Reviewed
• [Journal Article] Cardiovascular risk stratification with plasma B-type natriuretic peptide levels in a community-based hypertensive cohort. (2014)
  • Author(s): Sato K, Segawa T, Tanaka F, Takahashi T, Tanno K, Ohsawa M, Onoda T, Itai K, Sakata K, Omama S, Ogasawara K, Ishibashi Y, Makita S, Okayama A, Nakamura M.
  • Journal Title: Am J Cardiol. Volume: 113(4) Issue: 4 Pages: 682-6
  • DOI: 10.1016/j.amjcard.2013.11.012
  • Peer Reviewed
• [Journal Article] Plasma B-type natriuretic peptide as a predictor of cardiovascular events in subjects with atrial fibrillation: a community-based study. (2013)
  • Author(s): Nakamura M, Koeda Y, Tanaka F, Onoda T, Itai K, Ohsawa M, Tanno K, Sakata K, Omama S, Ishibashi Y, Makita S, Ohta M, Ogasawara K, Komatsu T, Okayama A.
  • Journal Title: PLoS One. Volume: 8(12) Issue: 12 Pages: e81243-e81243
  • DOI: 10.1371/journal.pone.0081243
  • Peer Reviewed
• [Journal Article] High risks of all-cause and cardiovascular deaths in apparently healthy middle-aged people with preserved glomerular filtration rate and albuminuria: A prospective cohort study. (2013)
  • Author(s): Ohsawa M, Fujioka T, Ogasawara K, Tanno K, Okamura T, Turin TC, Itai K, Ogawa A, Yoshida Y, Omama S, Onoda T, Nakamura M, Makita S, Ishibashi Y, Tanaka F, Kuribayashi T, Ohta M, Sakata K, and Okayama A.
  • Journal Title: Int J Cardiol. Volume: 170(2) Issue: 2 Pages: 167-172
  • DOI: 10.1016/j.ijcard.2013.10.076
  • Peer Reviewed
• [Journal Article] Predictive value of lipoprotein indices for residual risk of acute myocardial infarction and sudden death in men with low-density lipoprotein cholesterol levels < 120mg/dl (2013)
  • Author(s): Tanaka F, Makita S, Onoda T, Tanno K, Ohsawa M, Itai K, Sakata K, Omama S, Yoshida Y, Ogasawara K, Ogawa A, Ishibashi Y, Kuribayashi T, Okayama A, and Nakamura M
  • Journal Title: Am J Cardiol Volume: 112 Issue: 8 Pages: 1063-1068
  • DOI: 10.1016/j.amjcard.2013.05.049
  • Peer Reviewed
• [Journal Article] Factors related to tooth loss among community-dwelling middle-aged and elderly Japanese men (2013)
  • Author(s): Ando A, Ohsawa M, Yaegashi Y, Sakata K, Tanno K, Onoda T, Itai K, Tanaka F, Makita S, Omama S, Ogasawara K, Ogawa A, Ishibashi Y, Kuribayashi T, Koyama T, Okayama A
  • Journal Title: J Epidemiol Volume: 23 Pages: 301-6
  • NAID: 10031183197
  • Peer Reviewed
• [Journal Article] Comparison of predictability of future cardiovascular events between chronic kidney disease (CKD) stage based on CKD epidemiology collaboration equation and that based on modification of diet in renal disease equation in the Japanese general population--Iwate KENCO Study (2013)
  • Author(s): Ohsawa M, Tanno K, Itai K, Turin TC, Okamura T, Ogawa A, Ogasawara K, Fujioka T, Onoda T, Yoshida Y, Omama S, Ishibashi Y, Nakamura M, Makita S, Tanaka F, Kuribayashi T, Koyama T, Sakata K, Okayama A
  • Journal Title: Circ J Volume: 77 Pages: 1315-25
  • NAID: 10031151396
  • Peer Reviewed
• [Journal Article] Associations of marital status with mortality from all causes and mortality from cardiovascular disease in Japanese haemodialysis patients. (2013)
  • Author(s): Tanno K, Ohsawa M, Itai K, Kato K, Turin TC, Onoda T, Sakata K, Okayama A, Fujioka T.
  • Journal Title: Nephrol Dial Transplant. Volume: 28(4) Issue: 4 Pages: 1013-20
  • DOI: 10.1093/ndt/gfs547
  • Peer Reviewed
• [Journal Article] Concordance of CKD stages in estimation by the CKD-EPI equation and estimation by the MDRD equation in the Japanese general population: the Iwate KENCO Study. (2013)
  • Author(s): Ohsawa M, Tanno K, Itai K, Turin TC, Okamura T, Ogawa A, Ogasawara K, Fujioka T, Onoda T, Yoshida Y, Omama S, Ishibashi Y, Nakamura M, Makita S, Tanaka F, Kuribayashi T, Koyama T, Sakata K, and Okayama A.
  • Journal Title: Int J Cardiol Volume: 165(2) Issue: 2 Pages: 377-379
  • DOI: 10.1016/j.ijcard.2012.08.025
  • Peer Reviewed
• [Journal Article] Poor self-rated health is significantly associated with elevated C-reactive protein levels in women, but not in men, in the Japanese general population. (2013)
  • Author(s): Tanno K, Ohsawa M, Onoda T, Itai K, Sakata K, Tanaka F, Makita S, Nakamura M, Omama S, Ogasawara K, Ogawa A, Ishibashi Y, Kuribayashi T, Koyama T, and Okayama A.
  • Journal Title: J Psychosom Res Volume: 73(3) Issue: 3 Pages: 225-231
  • DOI: 10.1016/j.jpsychores.2012.05.013
  • Peer Reviewed
• [Journal Article] Factors related to tooth loss among community-dwelling middle-aged and elderly Japanese men. (2013)
  • Author(s): Ando A, Ohsawa M, Yaegashi Y, Sakata K, Tanno K, Onoda T, Itai K, Tanaka F, Makita S, Omama S, Ogasawara K, Ogawa A, Ishibashi Y, Kuribayashi T, Koyama T, Okayama A.
  • Journal Title: J Epidemiol. Volume: 23(4) Pages: 301-6
  • NAID: 10031183197
  • Peer Reviewed
• [Journal Article] Influence of the Great East Japan Earthquake and Tsunami 2011 on Occuerrence of Cerebrovascular Diseases in Iwate, Japan (2013)
  • Author(s): Shinichi Omama
  • Journal Title: Stroke Volume: 11 Issue: 6 Pages: 1518-24
  • DOI: 10.1161/strokeaha.111.000442
  • Peer Reviewed
• [Journal Article] Comparison of predictability of future cardiovascular events between chronic kidney disease (CKD) stage based on CKD epidemiology collaboration equation and that based on modification of diet in renal disease equation in the Japanese general population--Iwate KENCO Study. (2013)
  • Author(s): Ohsawa M, Tanno K, Itai K, Turin TC, Okamura T, Ogawa A, Ogasawara K, Fujioka T, Onoda T, Yoshida Y, Omama S, Ishibashi Y, Nakamura M, Makita S, Tanaka F, Kuribayashi T, Koyama T, Sakata K, Okayama A.
  • Journal Title: Circ J. Volume: 77(5) Pages: 1315-25
  • NAID: 10031151396
  • Peer Reviewed
• [Journal Article] Incidence rate of cerebrovascular diseases in northern Japan determined from the Iwate Stroke Registry with an inventory survey system. (2013)
  • Author(s): Omama S, Yoshida Y, Ogasawara K, Ogawa A, Ishibashi Y, Ohsawa M, Tanno K, Onoda T, Itai K, Sakata K, Okayama A.
  • Journal Title: J Stroke Cerebrovasc Dis. Volume: 22(8) Issue: 8 Pages: e317-e322
  • DOI: 10.1016/j.jstrokecerebrovasdis.2012.12.011
  • Peer Reviewed
• [Journal Article] Conflicting effect of alcohol on cardiovascular risk: a clue to understand the different etiologies of coronary artery disease, stroke and peripheral artery disease (2013)
  • Author(s): 大澤正樹
  • Journal Title: Hypertens Res. 2013 Jan;36(1):16-8. Volume: 36 Issue: 1 Pages: 16-18
  • DOI: 10.1038/hr.2012.152
  • Peer Reviewed
• [Journal Article] Influence of mild-to-moderate alcohol consumption on cardiovascular diseases in men from the general population (2012)
  • Author(s): Makita S, Onoda T, Ohsawa M, Tanaka F, Segawa T, Takahashi T, Satoh K, Itai K, Tanno K, Sakata K, Omama S, Yoshida Y, Ishibashi Y, Koyama T, Kuribayashi T, Ogasawara K, Ogawa A, Okayama A, and Nakamura M
  • Journal Title: Atherosclerosis Volume: 224 Issue: 1 Pages: 222-227
  • DOI: 10.1016/j.atherosclerosis.2012.07.004
  • Peer Reviewed
• [Journal Article] Plasma B-type natriuretic peptide is useful for cardiovascular risk assessment in community-based diabetes subjects : comparison with albuminuria (2012)
  • Author(s): Onodera M, Nakamura M, Tanaka F, Takahashi T, Makita S, Ishisone T, Ishibashi Y, Itai K, Onoda T, Ohsawa M, Tanno K, Sakata K, Omama S, Ogasawara K, Ogawa A, Kuribayashi T, Sakamaki K, Okayama A
  • Journal Title: Int Heart J Volume: 53 Pages: 176-81
  • Peer Reviewed
• [Journal Article] Sex-specific threshold levels of plasma B-type natriuretic Peptide for prediction of cardiovascular event risk in a Japanese population initially free of cardiovascular disease (2011)
  • Author(s): Nakamura M
  • Journal Title: Am J Cardiol Volume: 108 Issue: 11 Pages: 1564-1569
  • DOI: 10.1016/j.amjcard.2011.07.011
  • Peer Reviewed
• [Journal Article] Serum C-reactive protein levels and death and cardiovascular events in mild to moderate chronic kidney disease (2011)
  • Author(s): Koeda Y, Nakamura M, Tanaka F, Onoda T, Itai K, Tanno K, Ohsawa M, Makita S, Ishibashi Y, Koyama T, Yoshida Y, Omama S, Ogasawara K, Ogawa A, Kuribayashi T, Okayama A
  • Journal Title: Int Heart J Volume: 52 Pages: 180-4
  • NAID: 130000770918
  • Peer Reviewed
• [Journal Article] Sex-specific threshold levels of plasma B-type natriuretic peptide for prediction of cardiovascular event risk in a Japanese population initially free of cardiovascular disease (2011)
  • Author(s): 中村元行
  • Journal Title: American Journal of Cardiology Volume: 108 Pages: 1564-1569
  • Peer Reviewed
• [Presentation] Associations between serum albumin levels and risks for all-cause mortality and cause-specific mortality in an elderly Japanese community-dwelling population (2013)
  • Author(s): Tanno K, Ohsawa M, Onoda T, Sakata K,Tanaka F,Makita S,Nakamura M,Ishibashi T, Omama S, Ogasawara K,Kuribayashi T, Okayama A
  • Organizer: 52th Cardiovascular Disease Epidemiology and Prevention Annual Conference 2013
  • Place of Presentation: New Orleans, LA
  • Year and Date: 2013-03-19
• [Presentation] 慢性腎臓病と医療費との関連:岩手県北地域コホート研究 (2013)
  • Author(s): 丹野高三, 大澤正樹, 小野田敏行, 坂田清美, 栗林徹, 田中文隆, 蒔田真司, 中村元行, 石橋靖宏, 大間々真一, 小笠原邦昭, 板井一好, 岡山明
  • Organizer: 第23回日本疫学会学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2013-01-25
• [Presentation] Low-normal serum albumin levels are significantly associated with an increased risk for incident cardiovascular disease among elderly Japanese people (2013)
  • Author(s): Tanno K, Ohsawa M, Itai K, Onoda T, Ogawa A, Ogasawara K, Nakamura M, Sakata K, Makita S, Omama S, Tanaka F, Ishibashi Y, Okayama A
  • Organizer: 81th European Atherosclerosis Society Congress
  • Place of Presentation: Lyon France
• [Presentation] Low-normal serum albumin levels are significantly associated with an increased risk for incident cardiovascular disease among elderly Japanese people. (2013)
  • Author(s): Tanno K, Ohsawa M, Itai K, Onoda T, Ogawa A, Ogasawara K, Nakamura M, Sakata K, Makita S, Omama S, Tanaka F, Ishibashi Y, Okayama A.
  • Organizer: 81th European Atherosclerosis Society Congress
  • Place of Presentation: Lyon, France
• [Presentation] A Higher serum arsenic level is associated with a higher risk for incident myocardial infarction in hemodialysis patients. (2013)
  • Author(s): Ohsawa M, Tanno K, Itai K, Fujishima Y, Kato K, Onoda T, Sakata K, Okayama A, Fujioka T.
  • Organizer: 81th European Atherosclerosis Society Congress
  • Place of Presentation: Lyon, France
• [Presentation] Associations between serum albumin levels and risks for all-cause mortality and cause-specific mortality in an elderly Japanese community-dwelling population. (2013)
  • Author(s): 丹野高三
  • Organizer: EPI/NPAM 2013 Scientific Sessions
  • Place of Presentation: New Orleans, LA, USA.
• [Presentation] 慢性腎臓病と医療費との関連：岩手県北地域コホート研究 (2013)
  • Author(s): 丹野高三
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 吹田市
• [Presentation] Body mass index and stroke incidence in Japanese elderly men (2012)
  • Author(s): Tanno K, Ohsawa M, Itai K, Onoda T, Ogawa A, Ogasawara K, Nakamura M, Sakata K, Makita S, Omama S, Tanaka F, Ishibashi Y, Okayama A
  • Organizer: 51th Cardiovascular Disease Epidemiology and Prevention Annual Conference 2012
  • Place of Presentation: San Diego, CA
  • Year and Date: 2012-03-14
• [Presentation] 高齢者の貧血が死亡や介護認定に及ぼす影響:岩手県北地域コホート研究 (2012)
  • Author(s): 丹野高三, 大澤正樹, 小野田敏行, 坂田清美, 栗林徹, 田中文隆, 蒔田真司, 中村元行, 石橋靖宏, 大間々真一, 小笠原邦昭, 板井一好, 岡山明
  • Organizer: 第71回日本公衆衛生学会総会
  • Place of Presentation: 山口市
• [Presentation] 死亡小票に基づく死因決定と死因別死亡の内訳:岩手県北地域コホート研究の平均5.6年の追跡結果から (2012)
  • Author(s): 丹野高三, 大澤正樹, 小野田敏行, 板井一好, 坂田清美, 田中文隆, 蒔田真司, 中村元行, 石橋靖宏, 大間々真一, 小笠原邦昭, 小川彰, 栗林徹, 岡山明
  • Organizer: 第48回日本循環器病予防学会・日本循環器管理研究協議会総会.
  • Place of Presentation: 東京都
• [Presentation] Impact of chronic kidney disease on medical expenditures : a 5-year follow-up study of Japanese community dwelling people (2012)
  • Author(s): Tanno K, Ohsawa M, Onoda T, Itai K, Sakata K, Nakamura M, Ogasawara K, Fujioka T, Okayama A
  • Organizer: 80th European Atherosclerosis Society Congress
  • Place of Presentation: Milan, Italy
• [Presentation] 高齢者のbody mass indexと循環器疾患発症リスクとの関連:岩手県北地域コホート研究 (2012)
  • Author(s): 丹野高三, 栗林徹, 大澤正樹, 小野田敏行, 板井一好, 坂田清美, 田中文隆, 蒔田真司, 中村元行, 大間々真一, 小笠原邦昭, 小川彰, 石橋靖宏, 小山富子, 岡山明
  • Organizer: 第22回日本疫学会学術集会
  • Place of Presentation: 東京都
• [Presentation] 高齢者の貧血が死亡や介護認定に及ぼす影響：岩手県北地域コホート研究 (2012)
  • Author(s): 丹野高三
  • Organizer: 第71回日本公衆衛生学会総会
  • Place of Presentation: 山口市
• [Presentation] 死亡小票に基づく死因決定と死因別死亡の内訳：岩手県北地域コホート研究の平均5.6年の追跡結果から (2012)
  • Author(s): 丹野高三
  • Organizer: 第48回日本循環器病予防学会･日本循環器管理研究協議会総会
  • Place of Presentation: 東京都
• [Presentation] Impact of chronic kidney disease on medical expenditures: a 5-year follow-up study of Japanese community dwelling people (2012)
  • Author(s): 丹野高三
  • Organizer: 80th EAS Congress
  • Place of Presentation: Milan, Italy
• [Presentation] Body Mass Index and Stroke Incidence in Japanese Elderly Men (2012)
  • Author(s): 丹野高三
  • Organizer: Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2012 Scientific Sessions
  • Place of Presentation: Sheraton San Diego Hotel and Marina (San Diego)
• [Presentation] 高齢者のbody mass indexと循環器疾患発症リスクとの関連：岩手県北地域コホート研究 (2012)
  • Author(s): 丹野高三
  • Organizer: 第22回日本疫学会学術集会
  • Place of Presentation: 学術総合センター・一橋記念講堂
• [Presentation] 循環器疾患危険因子の集積状況が医療費支出に与える影響 (2011)
  • Author(s): 丹野高三, 大澤正樹, 小野田敏行, 板井一好, 坂田清美, 岡山明
  • Organizer: 第70回日本公衆衛生学会総会
  • Place of Presentation: 秋田市
• [Presentation] Can the direct homogenous low-density lipoprotein cholesterol assay be used in epidemiological studies? (2011)
  • Author(s): Tanno K, Okamura T, Ohsawa M, Nakamura M, Sakata K
  • Organizer: 第43回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 札幌市
• [Presentation] 循環器疾患危険因子の集積状況が医療費支出に与える影響 (2011)
  • Author(s): 丹野高三
  • Organizer: 第70回日本公衆衛生学会
  • Place of Presentation: 秋田アトリオン（秋田市）
• [Presentation] 慢性腎臓病者の死亡、心筋梗塞罹患、脳卒中罹患リスクは喫煙によりさらに上昇する (2011)
  • Author(s): 大澤正樹
  • Organizer: 第70回日本公衆衛生学会
  • Place of Presentation: 秋田アトリオン（秋田市）
• [Presentation] 沿岸地域の居住地標高が脳卒中罹患におよぼす影響について (2011)
  • Author(s): 小野田敏行
  • Organizer: 第70回日本公衆衛生学会
  • Place of Presentation: 秋田アトリオン（秋田市）
• [Presentation] Can the direct homogeneous low-density lipoprotein cholesterol assay be used in epidemiological studies? (2011)
  • Author(s): 丹野高三
  • Organizer: 第43回日本動脈硬化学会(招待講演)
  • Place of Presentation: ロイトン札幌（札幌市）
• [Presentation] 東日本大震災津波被災地域における末期腎不全患者の死亡率の変化に関する研究― 岩手県末期腎不全登録事業よる集計結果
  • Author(s): 大澤正樹, 藤岡知昭, 大森 聡, 岩動 孝, 丹野高三, 大間々真一, 石橋靖弘, 蒔田真司, 小野田敏行, 岡山 明.
  • Organizer: 第48回日本循環器病予防学会
  • Place of Presentation: 金沢市
• [Presentation] 心房細動による総死亡・死因別死亡リスク上昇についての検討
  • Author(s): 大澤正樹, 丹野高三, 板井一好, 小野田敏行, 小川彰, 小笠原邦昭, 吉田雄樹,大間々真一, 中村元行, 石橋靖宏, 蒔田真司, 田中文隆, 坂田清美, 栗林徹, 藤岡知昭, 岡村智教, 岡山明.
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: 熊本市