| Project/Area Number |
23590811
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
SATO Kenichi 東北薬科大学, 薬学部, 教授 (30158935)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Ken 東北大学, 医学(系)研究科, 非常勤講師 (00215782)
NAKAGAWA Yoshinori 東北大学, 医学(系)研究科, 非常勤講師 (20400351)
KAWAKAMI Jyunko 東北薬科大学, 薬学部, 講師 (40438560)
HOSHI Kenji 東北薬科大学, 薬学部, 講師 (20405913)
AOKI Sorama 東北薬科大学, 薬学部, 助手 (40584462)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 甲状腺機能異常 / スクリーニング / 基本的検査 / パターン認識手法 / 健康診断 / 健診 / 複数の基本的検査 / 病院 / CDSS / インフォマティクス |
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| Research Abstract |
We developed a new simple, low-cost method for detecting patients with overt thyroid dysfunction (PTD) using the combination of six routine tests already measured without measuring thyroid hormone. The existing procedure comprised 6 routine tests (alkaline phosphatase (ALP), serum creatinine (S-Cr), total cholesterol (TC), heart rate (HR), lactate dehydrogenase (LDH) and red blood cell (RBC)). Correcting for the effect of dosing in examinees taking cholesterol-lowering agents and extending to treat time series variation in routine tests succeeded in decreasing both false negatives and false positives. We performed this screening for many participants attending health-checkup at Ningen Docks in JR Sendai Hospital and Tohoku Kousai Hospital, and found more than 30 PTDs, none of them was suspected of thyroid dysfunction by a medical examination. More than 10,000 PTDs will be discovered annually if such screening is performed at all Ningen Docks in Japan.
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