| Project/Area Number |
23590819
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Hideaki 金沢医科大学, 医学部, 教授 (00097437)
YOSHITA Katsushi 大阪市立大学, 生活科学研究科, 教授 (60299245)
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| Co-Investigator(Renkei-kenkyūsha) |
MORIKAWA Yuko 金沢医科大学, 看護学部, 教授 (20210156)
NAKAMURA Koshi 金沢医科大学, 医学部, 准教授 (80422898)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 疫学 / 生活習慣病 / 内分泌学 |
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| Research Abstract |
This study investigated the association between chronic kidney disease, thyroid dysfunction and cardiovascular risk factors in Japanese men and women.
In a cross-sectional analyses, thyroid stimulating hormone (TSH) were related to the estimated glomerular filtration ratio (eGFR) (r=-0.125, p<0.001), and prevalence of thyroid dysfunction were higher in participants with low eGFR compared to those with normal eGFR.
Changes in TSH levels during a 3-year follow-up were not associated with baseline eGFR. Baseline TSH levels were not associated with a 3-year changes in cardiovascular risk factors such as blood pressure and plasma lipid levels. However, decrease in HDL-cholesterol were significantly higher for participants with hypothyroidism accompanied by renal dysfunction compared to those with normal thyroid/renal function. These results suggest that hypothyroidism accompanied by the renal dysfunction may higher the risk of cardiovascular disease through the decrease in HDL-cholesterol.
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