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Chronic kidney disease, thyroid dysfunction and cardiovascular risk

Research Project

Project/Area Number 23590819
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Public health/Health science
Research InstitutionKanazawa Medical University

Principal Investigator

SAKURAI Masaru  金沢医科大学, 医学部, 准教授 (90397216)

Co-Investigator(Kenkyū-buntansha) NAKAGAWA Hideaki  金沢医科大学, 医学部, 教授 (00097437)
YOSHITA Katsushi  大阪市立大学, 生活科学研究科, 教授 (60299245)
Co-Investigator(Renkei-kenkyūsha) MORIKAWA Yuko  金沢医科大学, 看護学部, 教授 (20210156)
NAKAMURA Koshi  金沢医科大学, 医学部, 准教授 (80422898)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords疫学 / 生活習慣病 / 内分泌学
Research Abstract

This study investigated the association between chronic kidney disease, thyroid dysfunction and cardiovascular risk factors in Japanese men and women.
In a cross-sectional analyses, thyroid stimulating hormone (TSH) were related to the estimated glomerular filtration ratio (eGFR) (r=-0.125, p<0.001), and prevalence of thyroid dysfunction were higher in participants with low eGFR compared to those with normal eGFR.
Changes in TSH levels during a 3-year follow-up were not associated with baseline eGFR. Baseline TSH levels were not associated with a 3-year changes in cardiovascular risk factors such as blood pressure and plasma lipid levels. However, decrease in HDL-cholesterol were significantly higher for participants with hypothyroidism accompanied by renal dysfunction compared to those with normal thyroid/renal function. These results suggest that hypothyroidism accompanied by the renal dysfunction may higher the risk of cardiovascular disease through the decrease in HDL-cholesterol.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (2 results)

All 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Association between serum thyroid stimulating hormone within the normal range and indices of obesity in Japanese men and women2014

    • Author(s)
      Sakurai M, Nakamura K, Miura K, Yoshita K, Takamura T, Nagasawa SY, Morikawa Y, Ishizaki M, Kido T, Naruse Y, Nakashima M, Nogawa N, Suwazono Y, Nakagawa H
    • Journal Title

      Intern Med

      Volume: 53 Pages: 669-674

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between a Serum Thyroid-stimulating Hormone Concentration within the Normal Range and Indices of Obesity in Japanese Men and Women2014

    • Author(s)
      Sakurai M, Nakamura K, Miura K, Yoshita K, Takamura T, Nagasawa SY, Morikawa Y, Ishizaki M, Kido T, Naruse Y, Nakashima M, Nogawa N, Suwazono Y, Nakagawa H.
    • Journal Title

      Internal Medicine

      Volume: 53 Issue: 7 Pages: 669-674

    • DOI

      10.2169/internalmedicine.53.1387

    • NAID

      130003392739

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed

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Published: 2011-08-05   Modified: 2019-07-29  

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