Chronic kidney disease, thyroid dysfunction and cardiovascular risk

• Project/Area Number: 23590819
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Kanazawa Medical University
• Principal Investigator: SAKURAI Masaru 金沢医科大学, 医学部, 准教授 (90397216)
• Co-Investigator(Kenkyū-buntansha): NAKAGAWA Hideaki 金沢医科大学, 医学部, 教授 (00097437) ; YOSHITA Katsushi 大阪市立大学, 生活科学研究科, 教授 (60299245)
• Co-Investigator(Renkei-kenkyūsha): MORIKAWA Yuko 金沢医科大学, 看護学部, 教授 (20210156) ; NAKAMURA Koshi 金沢医科大学, 医学部, 准教授 (80422898)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 疫学 / 生活習慣病 / 内分泌学

Research Abstract

This study investigated the association between chronic kidney disease, thyroid dysfunction and cardiovascular risk factors in Japanese men and women.
In a cross-sectional analyses, thyroid stimulating hormone (TSH) were related to the estimated glomerular filtration ratio (eGFR) (r=-0.125, p<0.001), and prevalence of thyroid dysfunction were higher in participants with low eGFR compared to those with normal eGFR.
Changes in TSH levels during a 3-year follow-up were not associated with baseline eGFR. Baseline TSH levels were not associated with a 3-year changes in cardiovascular risk factors such as blood pressure and plasma lipid levels. However, decrease in HDL-cholesterol were significantly higher for participants with hypothyroidism accompanied by renal dysfunction compared to those with normal thyroid/renal function. These results suggest that hypothyroidism accompanied by the renal dysfunction may higher the risk of cardiovascular disease through the decrease in HDL-cholesterol.

Research Products

• [Journal Article] Association between serum thyroid stimulating hormone within the normal range and indices of obesity in Japanese men and women (2014)
  • Author(s): Sakurai M, Nakamura K, Miura K, Yoshita K, Takamura T, Nagasawa SY, Morikawa Y, Ishizaki M, Kido T, Naruse Y, Nakashima M, Nogawa N, Suwazono Y, Nakagawa H
  • Journal Title: Intern Med Volume: 53 Pages: 669-674
  • Peer Reviewed
• [Journal Article] Association between a Serum Thyroid-stimulating Hormone Concentration within the Normal Range and Indices of Obesity in Japanese Men and Women (2014)
  • Author(s): Sakurai M, Nakamura K, Miura K, Yoshita K, Takamura T, Nagasawa SY, Morikawa Y, Ishizaki M, Kido T, Naruse Y, Nakashima M, Nogawa N, Suwazono Y, Nakagawa H.
  • Journal Title: Internal Medicine Volume: 53 Issue: 7 Pages: 669-674
  • DOI: 10.2169/internalmedicine.53.1387
  • NAID: 130003392739
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed