Relation of leptin and adiponectin to subclinical atherosclerosis

• Project/Area Number: 23590823
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Kyoto Women's University
• Principal Investigator: NAKAMURA Yasuyuki 京都女子大学, 家政学部, 教授 (20144371)
• Co-Investigator(Kenkyū-buntansha): UESHIMA Hirotsugu 滋賀医科大学, 医学部公衆衛生学講座, 名誉教授 (70144483) ; MIURA Katsuyuki 滋賀医科大学, 医学部公衆衛生学講座, 教授 (90257452)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 潜在的動脈硬化 / レプチン / アディポネクチン / 冠動脈石灰化 / 頸動脈内膜-中膜肥厚 / 頸動脈内膜-中膜肥厚度 / 頸動脈内中膜肥厚 / 潜在性動脈硬化 / 疫学研究

Research Abstract

Mean intima-media thickness (IMT), and Agaston score were significantly greater in the higher leptin concentration groups, and were significantly lower in the higher adiponectin concentration groups. In multiple linear regression models adjusted for confounders, log-leptin and log-adiponectin did not relate to IMT. In logistic regression models adjusted for age, log-leptin was significantly directly related to CAC (Agaston score>=10), but significantly inversely related to CAC in a model adjusted for multiple confounders. Log-adiponectin did not relate to CAC.
Log-leptin was significantly directly related to CAC in an age-adjusted model, but was significantly inversely related to CAC in a multivariable adjusted model. The inverse relation of leptin to CAC in multivariable analysis in this study may support clinical use of leptin in weight reduction.

Research Products

• [Journal Article] Impact of Metabolic Syndrome on the Risk of Cardiovascular Disease Mortality in the United States and in Japan (2014)
  • Author(s): Liu L, Miura K, Fujiyoshi A, Kadota A, Miyagawa N, Nakamura Y, Ohkubo T, Okayama A, Okamura T, Ueshima H
  • Journal Title: Am J Cardiol Volume: 113(1) Pages: 84-9
• [Journal Article] Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an Estimated 10-Year Absolute Risk of CAD Death According to the Japan Atherosclerosis Society (JAS) Guidelines 2012: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2013)
  • Author(s): Kadota A, Miura K, Okamura T, Fujiyoshi A, Ohkubo T, Kadowaki T, Takashima N, Hisamatsu T, Nakamura Y, Kasagi F, Maegawa H, Kashiwagi A, Ueshima H
  • Journal Title: J Atheroscler Thromb Volume: 20(10) Pages: 755-66
  • NAID: 130004444645
• [Journal Article] Serum leptin and total dietary energy intake : The INTERLIPID Study (2013)
  • Author(s): Nakamura Y, Ueshima H, Okuda N, Murakami Y, Miura K, Kita Y, Okamura T, Okayama A, Turin TC, Choudhry SR, Rodriguez B, Curb JD, Stamler J
  • Journal Title: Eur J Nutr Volume: 52(6) Pages: 1641-8
• [Journal Article] Prognostic Values of Bundle Branch Blocks for Cardiovascular Mortality in Japanese (24 Year Follow-up of NIPPON DATA80) (2013)
  • Author(s): Nakamura Y, Okamura T, Inohara T, Kohsaka S, Watanabe M, Higashiyama A, Kadota A, Okuda N, Ohkubo T, Nagasawa SY, Miura K, Okayama A, Ueshima H
  • Journal Title: J Electrocardiol Volume: 46(4) Pages: 360-5
• [Journal Article] Prognostic Values of Bundle Branch Blocks for Cardiovascular Mortality in Japanese (24 Year Follow-up of NIPPON DATA80). (2013)
  • Author(s): Nakamura Y, Okamura T, Inohara T, et al.
  • Journal Title: J Electrocardiol Volume: 46 Issue: 4 Pages: 360-365
  • DOI: 10.1016/j.jelectrocard.2013.03.009
  • Peer Reviewed
• [Journal Article] Interaction of Dietary n-3 Fatty Acids and J-point Elevation on Cardiac Mortality Risk in Japanese Men: A 24-Year Follow-Up of NIPPON DATA80. (2013)
  • Author(s): Hisamatsu T, Miura K, Horie M. et al.
  • Journal Title: Heart Volume: 99(14) Issue: 14 Pages: 1024-1029
  • DOI: 10.1136/heartjnl-2012-303496
  • Peer Reviewed
• [Journal Article] Serum leptin and total dietary energy intake: The INTERLIPID Study (2013)
  • Author(s): Nakamura Y, Ueshima H, Okuda N, et al.
  • Journal Title: Eur J Nutr Volume: 52 Issue: 6 Pages: 1641-1648
  • DOI: 10.1007/s00394-012-0469-3
  • Peer Reviewed
• [Journal Article] Serum leptin and total dietary energy intake: the INTERLIPID Study (2013)
  • Author(s): Nakamura Y, Ueshima H, Okuda N, Murakami Y, Miura K, Kita Y, Okamura T, Okayama A, Turin TC, Choudhry SR, Rodriguez B, Curb JD, Stamler J.
  • Journal Title: Eur J Nutr Volume: 52 Pages: 1641-8
  • Peer Reviewed
• [Journal Article] Prognostic values of bundle branch blocks for Cardiovascular Mortality in Japanese (24 Year Follow-up of NIPPON DATA80) (2013)
  • Author(s): Nakamura Y, Okamura T, Inohara T, Kohsaka S, Watanabe M, Higashiyama A, Kadota A, Okuda N, Ohkubo T, Nagasawa S, Miura K, Okayama A, Ueshima H
  • Journal Title: J Electrocardiol Volume: 46 Pages: 360-65
  • Peer Reviewed
• [Journal Article] Relationship between health-related quality of life and clustering of metabolic syndrome diagnostic components (2012)
  • Author(s): Katano S, Nakamura Y, Nakamura A, Suzukamo Y, Murakami Y, Tanaka T, Okayama A, Miura K, Okamura T, Fukuhara S, Ueshima H, HIPOP-OHP Research Group
  • Journal Title: Qual Life Res Volume: 21(7) Pages: 1165-1170
• [Journal Article] Prognostic Values of Clockwise and Counter-Clockwise Rotation for Cardiovascular Mortality in Japanese (24 Year Follow-up of NIPPON DATA80). (2012)
  • Author(s): Nakamura Y, Okamura T, Higashiyama A, Watanabe M, Kadota A, Ohkubo T, Miura K, Kasagi F, Kodama K, Okayama A, Ueshima H.
  • Journal Title: Circulation Volume: 125 Pages: 1226-33
  • Peer Reviewed
• [Journal Article] Prognostic values of clockwise and counterclockwise rotation for cardiovascular mortality in Japanese subjects: a 24-year follow-up of the National Integrated Project for Prospective Observation of Noncommunicable Disease and Its Trends in the Aged, 1980-2004 (NIPPON DATA80). (2012)
  • Author(s): Nakamura Y, Okamura T, Higashiyama A, Watanabe M, Kadota A, Ohkubo T, Miura K, Kasagi F, Kodama K, Okayama A, Ueshima H
  • Journal Title: Circulation Volume: 125 Pages: 1226-1233
  • Peer Reviewed
• [Journal Article] Research Group. Relation of dietary and lifestyle traits to difference in serum leptin of Japanese in Japan and Hawaii: The INTERLIPID study (2012)
  • Author(s): 116.Nakamura Y, Ueshima H, Okuda N, Miura K, Kita Y, Okamura T, Turin TC, Okayama A, Rodriguez B, Curb JD, Stamler J
  • Journal Title: Nutr Metab Cardiovasc Dis Volume: 22 Pages: 14-22
  • Peer Reviewed
• [Journal Article] Relationship between Dietary and Other Lifestyle Habits and Cardiometabolic Risk Factors in Men (2011)
  • Author(s): Katano S, Nakamura Y, Okuda N, Murakami Y, Chiba N, Yoshita K, Tanaka T, Tamaki J, Takebayashi T, Okayama A, Miura K, Okamura T, Ueshima H
  • Journal Title: Diabetol Metab Syndr Volume: 3. Pages: 30-30
  • Peer Reviewed
• [Journal Article] Relationship between sleep duration and clustering of metabolic syndrome diagnostic components (2011)
  • Author(s): Katano S, Nakamura Y, Nakamura A, Murakami Y, Tanaka T, Takebayashi T, Okayama A, Miura K, Okamura T, Ueshima H
  • Journal Title: Diabetes Metab Syndr Volume: 4 Pages: 119-125
  • Peer Reviewed
• [Presentation] Low-Carbohydrate-Diets and Cardiovascular and Total Mortality in Japanese. A 29-year Follow-up of NIPPON DATA80 (2014)
  • Author(s): Nakamura Y, Miura K, Ueshima H, et al
  • Organizer: American Heart Association Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2014 Scientific Sessions
  • Place of Presentation: San Francisco, CA
• [Presentation] 低炭水化物食と心血管死、総死亡の関連：NIPPON DATA80, 29年追跡結果 (2014)
  • Author(s): 中村保幸他
  • Organizer: 日本疫学会
  • Place of Presentation: 仙台
• [Presentation] Low-Carbohydrate-Diets and Cardiovascular and Total Mortality in Japanese. A 29-year Follow-up of NIPPON DATA80 (2014)
  • Author(s): Nakamura Y, et al
  • Organizer: American Heart Association, EPI/NPAM2014
  • Place of Presentation: San Francisco, CA, USA
• [Presentation] High-density Lipoprotein Particle Concentration is Independently Associated with Carotid Intima-media Thickness in Japanese Men (2013)
  • Author(s): Zaid M, Fujiyoshi A, Miura K, Okamura T, Takashima N, Nakamura Y, Ueshima H, et al
  • Organizer: American Heart Association Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2013 Scientific Sessions
  • Place of Presentation: New Orleans, LA
• [Presentation] The Relationship of Serum Marine-derived n-3 Fatty Acids and Carotid Intima-media Thickness Among General Japanese Men (2013)
  • Author(s): K adota A, Miura K, Nakamura Y, Ueshima H, et al
  • Organizer: American Heart Association Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2013 Scientific Sessions
  • Place of Presentation: New Orleans, LA
• [Presentation] Relation of Serum Leptin and Adiponectin Level to Serum C-Reactive Protein of Japanese in Japan and Japanese-Americans in Hawaii : The INTERLIPID Study (2013)
  • Author(s): Nakamura Y, Ueshima H, Okuda N, Miura K, et al
  • Organizer: American Heart Association Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2013 Scientific Sessions
  • Place of Presentation: New Orleans, LA
• [Presentation] Significant Inverse Association of Serum Docosahexaenoic Acid with Coronary Artery Calcification Among Men in the General Population in Japan (2013)
  • Author(s): Sekikawa A, Miura K, Nakamura Y, Ueshima H, et al
  • Organizer: American Heart Association Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2013 Scientific Sessions
  • Place of Presentation: New Orleans, LA
• [Presentation] Relation of Serum Leptin and Adiponectin Level to Serum C-Reactive Protein of Japanese in Japan and Japanese-Americans in Hawaii: The INTERLIPID Study (2013)
  • Author(s): Nakamura Y, Ueshima H, Stamler J et al.
  • Organizer: American Heart Association Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2013 Scientific Sessions
  • Place of Presentation: New Orleans
• [Presentation] Clockwise rotation was positively and counter-clockwise rotation was inversely associated with cardiovascular mortality in Japanese (24 Year Follow-up of NIPPON DATA80) (2012)
  • Author(s): Nakamura Y, Okamura T, Miura K, Ueshima H, et al
  • Organizer: European Society of Cardiology Congress 2012
  • Place of Presentation: Munich
• [Presentation] Fatty acids intakes and coronary heart disease mortality in Japan : NIPPON DATA90, 1990-2005 (2012)
  • Author(s): Nakamura Y, Miura K, Ueshima H, et al
  • Organizer: XVI International Symposium on Atherosclerosis
  • Place of Presentation: Sydney
• [Presentation] Saturated fatty acids intake, polyunsaturated fatty acid intake and coronary heart disease mortality in Japan : NIPPON DATA90 1990-2005 (2011)
  • Author(s): Nakamura Y, Miura K, Ueshima H et al
  • Organizer: European Society of Cardiology Congress 2011
  • Place of Presentation: Paris
• [Presentation] aturated fatty acids intake, polyunsaturated fatty acid intake and coronary heart disease mortality in Japan: NIPPON DATA90 1990-2005 (2011)
  • Author(s): Y. NakamuraY. Kiyohara, T. Okamura, A. Higashiyama, M. Watanabe, A. Kadota, S. Nagasawa, K. Miura, H. Ueshima.
  • Organizer: ESC Congress
  • Place of Presentation: Paris